ID CPLX3_HUMAN Reviewed; 158 AA. AC Q8WVH0; D3DW66; Q8TEM6; Q9H818; DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2002, sequence version 1. DT 15-MAR-2017, entry version 103. DE RecName: Full=Complexin-3; DE AltName: Full=Complexin III; DE Short=CPX III; DE Flags: Precursor; GN Name=CPLX3; ORFNames=Nbla11589; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RX PubMed=15911881; DOI=10.1083/jcb.200502115; RA Reim K., Wegmeyer H., Brandstaetter J.H., Xue M., Rosenmund C., RA Dresbach T., Hofmann K., Brose N.; RT "Structurally and functionally unique complexins at retinal ribbon RT synapses."; RL J. Cell Biol. 169:669-680(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Spleen; RA Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.; RT "The nucleotide sequence of a long cDNA clone isolated from human RT spleen."; RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Neuroblastoma; RX PubMed=12880961; DOI=10.1016/S0304-3835(03)00085-5; RA Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., RA Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., RA Hirato J., Nakagawara A.; RT "Neuroblastoma oligo-capping cDNA project: toward the understanding of RT the genesis and biology of neuroblastoma."; RL Cancer Lett. 197:63-68(2003). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Positively regulates a late step in synaptic vesicle CC exocytosis. {ECO:0000250}. CC -!- SUBUNIT: Binds to the SNARE core complex containing SNAP25, VAMP2 CC and STX1A. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Membrane; Lipid-anchor. Cell junction, CC synapse {ECO:0000250}. Note=Enriched at the synaptic terminal. CC {ECO:0000250}. CC -!- PTM: Farnesylation mediates presynaptic targeting. {ECO:0000250}. CC -!- SIMILARITY: Belongs to the complexin/synaphin family. CC {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAB84922.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY286501; AAP41127.1; -; mRNA. DR EMBL; AK074096; BAB84922.1; ALT_INIT; mRNA. DR EMBL; AB072900; BAE45711.1; -; mRNA. DR EMBL; AK024055; BAB14805.1; -; mRNA. DR EMBL; CH471136; EAW99306.1; -; Genomic_DNA. DR EMBL; CH471136; EAW99307.1; -; Genomic_DNA. DR EMBL; BC018026; AAH18026.1; -; mRNA. DR CCDS; CCDS32294.1; -. DR RefSeq; NP_001025176.1; NM_001030005.2. DR UniGene; Hs.187694; -. DR ProteinModelPortal; Q8WVH0; -. DR SMR; Q8WVH0; -. DR BioGrid; 534761; 17. DR STRING; 9606.ENSP00000378464; -. DR PhosphoSitePlus; Q8WVH0; -. DR BioMuta; CPLX3; -. DR DMDM; 74751549; -. DR PaxDb; Q8WVH0; -. DR PeptideAtlas; Q8WVH0; -. DR PRIDE; Q8WVH0; -. DR Ensembl; ENST00000395018; ENSP00000378464; ENSG00000213578. DR GeneID; 594855; -. DR KEGG; hsa:594855; -. DR UCSC; uc059llo.1; human. DR CTD; 594855; -. DR DisGeNET; 594855; -. DR GeneCards; CPLX3; -. DR HGNC; HGNC:27652; CPLX3. DR MIM; 609585; gene. DR neXtProt; NX_Q8WVH0; -. DR OpenTargets; ENSG00000213578; -. DR PharmGKB; PA142672081; -. DR eggNOG; ENOG410IWE3; Eukaryota. DR eggNOG; ENOG4111I8F; LUCA. DR GeneTree; ENSGT00490000043378; -. DR HOGENOM; HOG000111927; -. DR HOVERGEN; HBG060856; -. DR InParanoid; Q8WVH0; -. DR KO; K15295; -. DR OMA; TENCSLM; -. DR OrthoDB; EOG091G0X1S; -. DR PhylomeDB; Q8WVH0; -. DR TreeFam; TF331867; -. DR GenomeRNAi; 594855; -. DR PRO; PR:Q8WVH0; -. DR Proteomes; UP000005640; Chromosome 15. DR CleanEx; HS_CPLX3; -. DR Genevisible; Q8WVH0; HS. DR GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW. DR GO; GO:0005829; C:cytosol; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0098793; C:presynapse; IEA:GOC. DR GO; GO:0005326; F:neurotransmitter transporter activity; IEA:Ensembl. DR GO; GO:0030073; P:insulin secretion; IEA:Ensembl. DR GO; GO:0046928; P:regulation of neurotransmitter secretion; IEA:Ensembl. DR GO; GO:0016079; P:synaptic vesicle exocytosis; IEA:Ensembl. DR InterPro; IPR008849; Synaphin. DR PANTHER; PTHR16705; PTHR16705; 1. DR Pfam; PF05835; Synaphin; 1. PE 2: Evidence at transcript level; KW Cell junction; Coiled coil; Complete proteome; Exocytosis; KW Lipoprotein; Membrane; Methylation; Neurotransmitter transport; KW Prenylation; Reference proteome; Synapse; Transport. FT CHAIN 1 155 Complexin-3. FT /FTId=PRO_0000239272. FT PROPEP 156 158 Removed in mature form. {ECO:0000250}. FT /FTId=PRO_0000240233. FT COILED 39 74 {ECO:0000255}. FT MOD_RES 155 155 Cysteine methyl ester. {ECO:0000250}. FT LIPID 155 155 S-farnesyl cysteine. {ECO:0000250}. FT CONFLICT 19 19 S -> G (in Ref. 4; BAB14805). FT {ECO:0000305}. SQ SEQUENCE 158 AA; 17557 MW; 057B4DE06DB6EA0F CRC64; MAFMVKTMVG GQLKNLTGSL GGGEDKGDGD KSAAEAQGMS REEYEEYQKQ LVEEKMERDA QFTQRKAERA TLRSHFRDKY RLPKNETDES QIQMAGGDVE LPRELAKMIE EDTEEEEEKA SVLGQLASLP GLNLGSLKDK AQATLGDLKQ SAEKCHVM //