ID   NAT14_HUMAN             Reviewed;         206 AA.
AC   Q8WUY8; Q8TDY7; Q9NS72;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   17-JUN-2020, entry version 133.
DE   RecName: Full=N-acetyltransferase 14;
DE            EC=2.3.1.-;
DE   AltName: Full=K562 cell-derived leucine-zipper-like protein 1;
GN   Name=NAT14; Synonyms=KLP1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, DNA-BINDING, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=10873651; DOI=10.1006/bbrc.2000.2991;
RA   Takahashi S., Furuyama K., Kobayashi A., Taketani S., Harigae H.,
RA   Yamamoto M., Igarashi K., Sasaki T., Hayashi N.;
RT   "Cloning of a coproporphyrinogen oxidase promoter regulatory element
RT   binding protein.";
RL   Biochem. Biophys. Res. Commun. 273:596-602(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11779635; DOI=10.1016/s0167-4781(01)00349-9;
RA   Takahashi S., Harigae H., Yokoyama H., Kaku M., Sasaki T.;
RT   "Genomic structure and regulation of a novel human gene, Klp1.";
RL   Biochim. Biophys. Acta 1522:207-211(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probable acetyltransferase that binds the 5'-GGACTACAG-3'
CC       sequence of coproporphyrinogen oxidase promoter. Able to activate
CC       transcription of a reporter construct in vitro.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in K-562 and HeLa cell lines and in
CC       brain. {ECO:0000269|PubMed:10873651}.
CC   -!- SIMILARITY: Belongs to the camello family. {ECO:0000305}.
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DR   EMBL; AB038651; BAB03716.1; -; mRNA.
DR   EMBL; AB055059; BAB85857.1; -; Genomic_DNA.
DR   EMBL; BC019079; AAH19079.1; -; mRNA.
DR   CCDS; CCDS12926.1; -.
DR   PIR; JC7320; JC7320.
DR   RefSeq; NP_065111.1; NM_020378.3.
DR   BioGRID; 121372; 27.
DR   IntAct; Q8WUY8; 26.
DR   MINT; Q8WUY8; -.
DR   STRING; 9606.ENSP00000205194; -.
DR   PhosphoSitePlus; Q8WUY8; -.
DR   SwissPalm; Q8WUY8; -.
DR   BioMuta; NAT14; -.
DR   DMDM; 74730785; -.
DR   EPD; Q8WUY8; -.
DR   jPOST; Q8WUY8; -.
DR   MassIVE; Q8WUY8; -.
DR   MaxQB; Q8WUY8; -.
DR   PaxDb; Q8WUY8; -.
DR   PeptideAtlas; Q8WUY8; -.
DR   PRIDE; Q8WUY8; -.
DR   ProteomicsDB; 74727; -.
DR   Antibodypedia; 33111; 90 antibodies.
DR   DNASU; 57106; -.
DR   Ensembl; ENST00000205194; ENSP00000205194; ENSG00000090971.
DR   GeneID; 57106; -.
DR   KEGG; hsa:57106; -.
DR   UCSC; uc002qle.3; human.
DR   CTD; 57106; -.
DR   DisGeNET; 57106; -.
DR   EuPathDB; HostDB:ENSG00000090971.4; -.
DR   GeneCards; NAT14; -.
DR   HGNC; HGNC:28918; NAT14.
DR   HPA; ENSG00000090971; Tissue enhanced (lymphoid).
DR   neXtProt; NX_Q8WUY8; -.
DR   OpenTargets; ENSG00000090971; -.
DR   PharmGKB; PA162396977; -.
DR   eggNOG; ENOG410JB7C; Eukaryota.
DR   eggNOG; ENOG4112DCG; LUCA.
DR   GeneTree; ENSGT00950000182932; -.
DR   HOGENOM; CLU_127402_0_0_1; -.
DR   InParanoid; Q8WUY8; -.
DR   OMA; RWHRRQG; -.
DR   OrthoDB; 1318443at2759; -.
DR   PhylomeDB; Q8WUY8; -.
DR   TreeFam; TF336981; -.
DR   BioGRID-ORCS; 57106; 6 hits in 792 CRISPR screens.
DR   ChiTaRS; NAT14; human.
DR   GenomeRNAi; 57106; -.
DR   Pharos; Q8WUY8; Tbio.
DR   PRO; PR:Q8WUY8; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q8WUY8; protein.
DR   Bgee; ENSG00000090971; Expressed in right hemisphere of cerebellum and 175 other tissues.
DR   ExpressionAtlas; Q8WUY8; baseline and differential.
DR   Genevisible; Q8WUY8; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008080; F:N-acetyltransferase activity; IEA:InterPro.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; NAS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; NAS:UniProtKB.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR000182; GNAT_dom.
DR   Pfam; PF00583; Acetyltransf_1; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS51186; GNAT; 1.
PE   1: Evidence at protein level;
KW   Activator; Acyltransferase; DNA-binding; Membrane; Reference proteome;
KW   Transcription; Transcription regulation; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..206
FT                   /note="N-acetyltransferase 14"
FT                   /id="PRO_0000307786"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          6..206
FT                   /note="N-acetyltransferase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00532"
FT   CONFLICT        21..24
FT                   /note="Missing (in Ref. 2; BAB85857)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        187
FT                   /note="A -> V (in Ref. 1; BAB03716)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   206 AA;  21650 MW;  EA8CF3AD64627970 CRC64;
     MAPSHLSVRE MREDEKPLVL EMLKAGVKDT ENRVALHALT RPPALLLLAA ASSGLRFVLA
     SFALALLLPV FLAVAAVKLG LRARWGSLPP PGGLGGPWVA VRGSGDVCGV LALAPGTNAG
     DGARVTRLSV SRWHRRRGVG RRLLAFAEAR ARAWAGGMGE PRARLVVPVA VAAWGVGGML
     EGCGYQAEGG WGCLGYTLVR EFSKDL
//