ID   UBTD2_HUMAN             Reviewed;         234 AA.
AC   Q8WUN7; Q8TDQ3;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2006, sequence version 2.
DT   12-AUG-2020, entry version 136.
DE   RecName: Full=Ubiquitin domain-containing protein 2;
DE   AltName: Full=Dendritic cell-derived ubiquitin-like protein;
DE            Short=DC-UbP;
DE   AltName: Full=Ubiquitin-like protein SB72;
GN   Name=UBTD2; Synonyms=DCUBP; ORFNames=SB72;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-234.
RC   TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 122-234, SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RC   TISSUE=Dendritic cell;
RX   PubMed=12507522; DOI=10.1016/s0006-291x(02)02913-3;
RA   Liu S., An H., Li N., Yu Y., Lin N., Wan T., Zhang M., Wang W., Cao X.;
RT   "Cloning and identification of a novel human ubiquitin-like protein, DC-
RT   UbP, from dendritic cells.";
RL   Biochem. Biophys. Res. Commun. 300:800-805(2003).
RN   [4]
RP   STRUCTURE BY NMR OF 129-234.
RX   PubMed=15987890; DOI=10.1110/ps.051455505;
RA   Gao Y.-G., Song A.-X., Shi Y.-H., Chang Y.-G., Liu S.-X., Yu Y.-Z.,
RA   Cao X.-T., Lin D.-H., Hu H.-Y.;
RT   "Solution structure of the ubiquitin-like domain of human DC-UbP from
RT   dendritic cells.";
RL   Protein Sci. 14:2044-2050(2005).
CC   -!- INTERACTION:
CC       Q8WUN7; Q13520: AQP6; NbExp=3; IntAct=EBI-12867288, EBI-13059134;
CC       Q8WUN7; Q03989: ARID5A; NbExp=3; IntAct=EBI-12867288, EBI-948603;
CC       Q8WUN7; P07902: GALT; NbExp=4; IntAct=EBI-12867288, EBI-750827;
CC       Q8WUN7; Q13227: GPS2; NbExp=3; IntAct=EBI-12867288, EBI-713355;
CC       Q8WUN7; Q0VD86: INCA1; NbExp=3; IntAct=EBI-12867288, EBI-6509505;
CC       Q8WUN7; Q6PF15: KLHL35; NbExp=3; IntAct=EBI-12867288, EBI-9477654;
CC       Q8WUN7; Q9NRX2: MRPL17; NbExp=3; IntAct=EBI-12867288, EBI-7825154;
CC       Q8WUN7; Q14764: MVP; NbExp=3; IntAct=EBI-12867288, EBI-2816254;
CC       Q8WUN7; P78317: RNF4; NbExp=3; IntAct=EBI-12867288, EBI-2340927;
CC       Q8WUN7; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-12867288, EBI-492476;
CC       Q8WUN7; Q9Y2X8: UBE2D4; NbExp=3; IntAct=EBI-12867288, EBI-745527;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12507522}.
CC   -!- TISSUE SPECIFICITY: Detected in dendritic cells. Highly expressed in
CC       tumor cell lines, but not detectable in most tissues.
CC       {ECO:0000269|PubMed:12507522}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH19910.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAL99389.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AC008671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC024561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC019910; AAH19910.1; ALT_INIT; mRNA.
DR   EMBL; AF251700; AAL99389.1; ALT_INIT; mRNA.
DR   CCDS; CCDS4379.2; -.
DR   RefSeq; NP_689490.2; NM_152277.2.
DR   RefSeq; XP_016865511.1; XM_017010022.1.
DR   RefSeq; XP_016865512.1; XM_017010023.1.
DR   PDB; 1TTN; NMR; -; A=129-234.
DR   PDB; 2KSN; NMR; -; A=14-141.
DR   PDBsum; 1TTN; -.
DR   PDBsum; 2KSN; -.
DR   SMR; Q8WUN7; -.
DR   BioGRID; 124917; 13.
DR   IntAct; Q8WUN7; 20.
DR   STRING; 9606.ENSP00000377381; -.
DR   iPTMnet; Q8WUN7; -.
DR   PhosphoSitePlus; Q8WUN7; -.
DR   SwissPalm; Q8WUN7; -.
DR   BioMuta; UBTD2; -.
DR   DMDM; 109896149; -.
DR   EPD; Q8WUN7; -.
DR   jPOST; Q8WUN7; -.
DR   MassIVE; Q8WUN7; -.
DR   MaxQB; Q8WUN7; -.
DR   PaxDb; Q8WUN7; -.
DR   PeptideAtlas; Q8WUN7; -.
DR   PRIDE; Q8WUN7; -.
DR   ProteomicsDB; 74697; -.
DR   Antibodypedia; 28892; 169 antibodies.
DR   DNASU; 92181; -.
DR   Ensembl; ENST00000393792; ENSP00000377381; ENSG00000168246.
DR   GeneID; 92181; -.
DR   KEGG; hsa:92181; -.
DR   UCSC; uc003mbp.2; human.
DR   CTD; 92181; -.
DR   EuPathDB; HostDB:ENSG00000168246.5; -.
DR   GeneCards; UBTD2; -.
DR   HGNC; HGNC:24463; UBTD2.
DR   HPA; ENSG00000168246; Low tissue specificity.
DR   MIM; 610174; gene.
DR   neXtProt; NX_Q8WUN7; -.
DR   OpenTargets; ENSG00000168246; -.
DR   PharmGKB; PA162408325; -.
DR   eggNOG; KOG0013; Eukaryota.
DR   GeneTree; ENSGT00940000156641; -.
DR   HOGENOM; CLU_070348_0_0_1; -.
DR   InParanoid; Q8WUN7; -.
DR   OMA; GTGGECQ; -.
DR   OrthoDB; 1221075at2759; -.
DR   PhylomeDB; Q8WUN7; -.
DR   TreeFam; TF323925; -.
DR   PathwayCommons; Q8WUN7; -.
DR   BioGRID-ORCS; 92181; 2 hits in 872 CRISPR screens.
DR   ChiTaRS; UBTD2; human.
DR   EvolutionaryTrace; Q8WUN7; -.
DR   GenomeRNAi; 92181; -.
DR   Pharos; Q8WUN7; Tbio.
DR   PRO; PR:Q8WUN7; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; Q8WUN7; protein.
DR   Bgee; ENSG00000168246; Expressed in forebrain and 224 other tissues.
DR   Genevisible; Q8WUN7; HS.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.225.20; -; 1.
DR   InterPro; IPR032752; DC-UbP/UBTD2_N.
DR   InterPro; IPR038169; DC-UbP/UBTD2_N_sf.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR039869; UBTD1/2.
DR   PANTHER; PTHR13609; PTHR13609; 1.
DR   Pfam; PF16455; UBD; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Polymorphism; Reference proteome.
FT   CHAIN           1..234
FT                   /note="Ubiquitin domain-containing protein 2"
FT                   /id="PRO_0000244332"
FT   DOMAIN          152..227
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT   VARIANT         129
FT                   /note="M -> I (in dbSNP:rs17074452)"
FT                   /id="VAR_052694"
FT   STRAND          21..23
FT                   /evidence="ECO:0000244|PDB:2KSN"
FT   HELIX           47..58
FT                   /evidence="ECO:0000244|PDB:2KSN"
FT   HELIX           68..82
FT                   /evidence="ECO:0000244|PDB:2KSN"
FT   HELIX           86..96
FT                   /evidence="ECO:0000244|PDB:2KSN"
FT   STRAND          105..110
FT                   /evidence="ECO:0000244|PDB:2KSN"
FT   TURN            111..113
FT                   /evidence="ECO:0000244|PDB:2KSN"
FT   STRAND          114..117
FT                   /evidence="ECO:0000244|PDB:2KSN"
FT   HELIX           120..122
FT                   /evidence="ECO:0000244|PDB:2KSN"
FT   TURN            127..129
FT                   /evidence="ECO:0000244|PDB:2KSN"
FT   TURN            133..135
FT                   /evidence="ECO:0000244|PDB:2KSN"
FT   STRAND          151..158
FT                   /evidence="ECO:0000244|PDB:1TTN"
FT   TURN            159..161
FT                   /evidence="ECO:0000244|PDB:1TTN"
FT   STRAND          162..168
FT                   /evidence="ECO:0000244|PDB:1TTN"
FT   HELIX           173..183
FT                   /evidence="ECO:0000244|PDB:1TTN"
FT   STRAND          193..196
FT                   /evidence="ECO:0000244|PDB:1TTN"
FT   HELIX           206..209
FT                   /evidence="ECO:0000244|PDB:1TTN"
FT   STRAND          213..215
FT                   /evidence="ECO:0000244|PDB:1TTN"
FT   STRAND          217..221
FT                   /evidence="ECO:0000244|PDB:1TTN"
SQ   SEQUENCE   234 AA;  26190 MW;  9FB195CDDE83583E CRC64;
     MGGCVGAQHD SSGSLNENSE GTGVALGRNQ PLKKEKPKWK SDYPMTDGQL RSKRDEFWDT
     APAFEGRKEI WDALKAAAHA FESNDHELAQ AIIDGANITL PHGALTECYD ELGNRYQLPV
     YCLAPPINMI EEKSDIETLD IPEPPPNSGY ECQLRLRLST GKDLKLVVRS TDTVFHMKRR
     LHAAEGVEPG SQRWFFSGRP LTDKMKFEEL KIPKDYVVQV IVSQPVQNPT PVEN
//