ID NU133_HUMAN Reviewed; 1156 AA. AC Q8WUM0; Q5T8N0; Q9H9W2; Q9NV71; Q9NVC4; DT 28-MAR-2003, integrated into UniProtKB/Swiss-Prot. DT 03-APR-2007, sequence version 2. DT 10-JUN-2008, entry version 64. DE Nuclear pore complex protein Nup133 (Nucleoporin Nup133) (133 kDa DE nucleoporin). GN Name=NUP133; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., RA Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Skin; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP IDENTIFICATION, SUBUNIT, AND SUBCELLULAR LOCATION. RX MEDLINE=21448620; PubMed=11564755; DOI=10.1083/jcb.200101081; RA Belgareh N., Rabut G., Bai S.W., van Overbeek M., Beaudouin J., RA Daigle N., Zatsepina O.V., Pasteau F., Labas V., Fromont-Racine M., RA Ellenberg J., Doye V.; RT "An evolutionarily conserved NPC subcomplex, which redistributes in RT part to kinetochores in mammalian cells."; RL J. Cell Biol. 154:1147-1160(2001). RN [5] RP IDENTIFICATION, FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION. RX MEDLINE=21541555; PubMed=11684705; DOI=10.1083/jcb.200108007; RA Vasu S., Shah S., Orjalo A., Park M., Fischer W.H., Forbes D.J.; RT "Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA RT export."; RL J. Cell Biol. 155:339-354(2001). RN [6] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 AND SER-50, AND MASS RP SPECTROMETRY. RC TISSUE=Epithelium; RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026; RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., RA Mann M.; RT "Global, in vivo, and site-specific phosphorylation dynamics in RT signaling networks."; RL Cell 127:635-648(2006). RN [7] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27; THR-28 AND SER-45, RP AND MASS SPECTROMETRY. RC TISSUE=Epithelium; RX PubMed=16565220; DOI=10.1073/pnas.0507066103; RA Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; RT "Phosphoproteome analysis of the human mitotic spindle."; RL Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). RN [8] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 AND SER-50, AND MASS RP SPECTROMETRY. RC TISSUE=Epithelium; RX PubMed=16964243; DOI=10.1038/nbt1240; RA Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; RT "A probability-based approach for high-throughput protein RT phosphorylation analysis and site localization."; RL Nat. Biotechnol. 24:1285-1292(2006). RN [9] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 AND SER-50, AND MASS RP SPECTROMETRY. RX PubMed=18220336; DOI=10.1021/pr0705441; RA Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., RA Yates J.R. III; RT "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for RT efficient phosphoproteomic analysis."; RL J. Proteome Res. 7:1346-1351(2008). RN [10] RP X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 67-514. RX PubMed=15557116; DOI=10.1083/jcb.200408109; RA Berke I.C., Boehmer T., Blobel G., Schwartz T.U.; RT "Structural and functional analysis of Nup133 domains reveals modular RT building blocks of the nuclear pore complex."; RL J. Cell Biol. 167:591-597(2004). RN [11] RP VARIANTS [LARGE SCALE ANALYSIS] VAL-326 AND ARG-448. RX PubMed=16959974; DOI=10.1126/science.1133427; RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., RA Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., RA Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., RA Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., RA Vogelstein B., Kinzler K.W., Velculescu V.E.; RT "The consensus coding sequences of human breast and colorectal RT cancers."; RL Science 314:268-274(2006). CC -!- FUNCTION: Involved in poly(A)+ RNA transport. CC -!- SUBUNIT: Forms part of the Nup160 subcomplex in the nuclear pore CC which is composed of Nup160, Nup133, Nup107 and Nup96. This CC complex plays a role in RNA export and in tethering Nup98 and CC Nup153 to the nucleus. CC -!- INTERACTION: CC P57740:NUP107; NbExp=1; IntAct=EBI-295695, EBI-295687; CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex. Kinetochore. CC Note=Located on both the cytoplasmic and nuclear sides of the CC nuclear pore. During mitosis, localizes to the kinetochores. CC -!- SIMILARITY: Belongs to the nucleoporin Nup133 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK001676; BAA91829.1; -; mRNA. DR EMBL; AK001754; BAA91885.1; ALT_INIT; mRNA. DR EMBL; AK022572; BAB14106.1; ALT_INIT; mRNA. DR EMBL; AL121990; CAI22011.1; -; Genomic_DNA. DR EMBL; AL139252; CAI22011.1; JOINED; Genomic_DNA. DR EMBL; AL160004; CAI22011.1; JOINED; Genomic_DNA. DR EMBL; AL139252; CAI22354.1; -; Genomic_DNA. DR EMBL; AL121990; CAI22354.1; JOINED; Genomic_DNA. DR EMBL; AL160004; CAI22354.1; JOINED; Genomic_DNA. DR EMBL; AL160004; CAI19048.1; -; Genomic_DNA. DR EMBL; AL121990; CAI19048.1; JOINED; Genomic_DNA. DR EMBL; AL139252; CAI19048.1; JOINED; Genomic_DNA. DR EMBL; BC020107; AAH20107.1; -; mRNA. DR RefSeq; NP_060700.2; -. DR UniGene; Hs.12457; -. DR PDB; 1XKS; X-ray; 2.35 A; A=67-514. DR PDBsum; 1XKS; -. DR DisProt; DP00318; -. DR IntAct; Q8WUM0; -. DR PhosphoSite; Q8WUM0; -. DR Ensembl; ENSG00000069248; Homo sapiens. DR GeneID; 55746; -. DR KEGG; hsa:55746; -. DR H-InvDB; HIX0001680; -. DR HGNC; HGNC:18016; NUP133. DR MIM; 607613; gene. DR PharmGKB; PA31847; -. DR HOGENOM; Q8WUM0; -. DR HOVERGEN; Q8WUM0; -. DR Reactome; REACT_6185; HIV Infection. DR ArrayExpress; Q8WUM0; -. DR CleanEx; HS_NUP133; -. DR GermOnline; ENSG00000069248; Homo sapiens. DR GO; GO:0005643; C:nuclear pore; IDA:UniProtKB. DR GO; GO:0005487; F:nucleocytoplasmic transporter activity; IDA:UniProtKB. DR GO; GO:0005515; F:protein binding; IPI:IntAct. DR GO; GO:0006406; P:mRNA export from nucleus; IDA:UniProtKB. DR InterPro; IPR007187; Nucleoporin_Nup133_C. DR InterPro; IPR014908; Nup133_N. DR InterPro; IPR015943; WD40/YVTN_repeat-like. DR Gene3D; G3DSA:2.130.10.10; WD40/YVTN_repeat-like; 1. DR Pfam; PF04044; Nup133; 1. DR Pfam; PF08801; Nup133_N; 1. PE 1: Evidence at protein level; KW 3D-structure; mRNA transport; Nuclear pore complex; Nucleus; KW Phosphoprotein; Polymorphism; Protein transport; Translocation; KW Transport. FT CHAIN 1 1156 Nuclear pore complex protein Nup133. FT /FTId=PRO_0000204838. FT MOD_RES 27 27 Phosphoserine. FT MOD_RES 28 28 Phosphothreonine. FT MOD_RES 45 45 Phosphoserine. FT MOD_RES 50 50 Phosphoserine. FT MOD_RES 501 501 Phosphoserine (By similarity). FT VARIANT 106 106 T -> P (in dbSNP:rs428231). FT /FTId=VAR_030829. FT VARIANT 294 294 I -> V (in dbSNP:rs11805194). FT /FTId=VAR_030830. FT VARIANT 326 326 G -> V (in a breast cancer sample; FT somatic mutation). FT /FTId=VAR_035854. FT VARIANT 406 406 Q -> R (in dbSNP:rs1065674). FT /FTId=VAR_030831. FT VARIANT 448 448 G -> R (in a breast cancer sample; FT somatic mutation). FT /FTId=VAR_035855. FT CONFLICT 61 61 R -> G (in Ref. 1; BAA91829). FT CONFLICT 146 146 P -> S (in Ref. 1; BAA91829). FT CONFLICT 345 345 L -> F (in Ref. 3; AAH20107). FT CONFLICT 626 626 S -> N (in Ref. 1; BAA91829). FT CONFLICT 928 928 F -> L (in Ref. 1; BAA91885). FT STRAND 77 83 FT HELIX 90 98 FT STRAND 105 109 FT STRAND 113 119 FT STRAND 122 127 FT HELIX 134 136 FT STRAND 139 143 FT HELIX 153 155 FT STRAND 156 160 FT STRAND 172 178 FT STRAND 183 188 FT STRAND 197 200 FT STRAND 209 215 FT TURN 216 218 FT STRAND 219 224 FT STRAND 229 234 FT STRAND 240 244 FT STRAND 274 280 FT TURN 281 284 FT STRAND 285 299 FT STRAND 304 311 FT HELIX 312 325 FT HELIX 331 335 FT STRAND 339 348 FT STRAND 351 359 FT STRAND 363 365 FT STRAND 367 375 FT STRAND 386 390 FT HELIX 400 402 FT STRAND 406 408 FT STRAND 412 420 FT STRAND 422 429 FT STRAND 440 443 FT HELIX 446 448 FT STRAND 451 457 FT STRAND 460 465 FT TURN 466 468 FT STRAND 469 475 SQ SEQUENCE 1156 AA; 128979 MW; 78B733E353824577 CRC64; MFPAAPSPRT PGTGSRRGPL AGLGPGSTPR TASRKGLPLG SAVSSPVLFS PVGRRSSLSS RGTPTRMFPH HSITESVNYD VKTFGSSLPV KVMEALTLAE VDDQLTINID EGGWACLVCK EKLIIWKIAL SPITKLSVCK ELQLPPSDFH WSADLVALSY SSPSGEAHST QAVAVMVATR EGSIRYWPSL AGEDTYTEAF VDSGGDKTYS FLTAVQGGSF ILSSSGSQLI RLIPESSGKI HQHILPQGQG MLSGIGRKVS SLFGILSPSS DLTLSSVLWD RERSSFYSLT SSNISKWELD DSSEKHAYSW DINRALKENI TDAIWGSESN YEAIKEGVNI RYLDLKQNCD GLVILAAAWH SADNPCLIYY SLITIEDNGC QMSDAVTVEV TQYNPPFQSE DLILCQLTVP NFSNQTAYLY NESAVYVCST GTGKFSLPQE KIVFNAQGDS VLGAGACGGV PIIFSRNSGL VSITSRENVS ILAEDLEGSL ASSVAGPNSE SMIFETTTKN ETIAQEDKIK LLKAAFLQYC RKDLGHAQMV VDELFSSHSD LDSDSELDRA VTQISVDLMD DYPASDPRWA ESVPEEAPGF SNTSLIILHQ LEDKMKAHSF LMDFIHQVGL FGRLGSFPVR GTPMATRLLL CEHAEKLSAA IVLKNHHSRL SDLVNTAILI ALNKREYEIP SNLTPADVFF REVSQVDTIC ECLLEHEEQV LRDAPMDSIE WAEVVINVNN ILKDMLQAAS HYRQNRNSLY RREESLEKEP EYVPWTATSG PGGIRTVIIR QHEIVLKVAY PQADSNLRNI VTEQLVALID CFLDGYVSQL KSVDKSSNRE RYDNLEMEYL QKRSDLLSPL LSLGQYLWAA SLAEKYCDFD ILVQMCEQTD NQSRLQRYMT QFADQNFSDF LFRWYLEKGK RGKLLSQPIS QHGQLANFLQ AHEHLSWLHE INSQELEKAH ATLLGLANME TRYFAKKKTL LGLSKLAALA SDFSEDMLQE KIEEMAEQER FLLHQETLPE QLLAEKQLNL SAMPVLTAPQ LIGLYICEEN RRANEYDFKK ALDLLEYIDE EEDININDLK LEILCKALQR DNWSSSDGKD DPIEVSKDSI FVKILQKLLK DGIQLSEYLP EVKDLLQADQ LGSLKSNPYF EFVLKANYEY YVQGQI //