ID Q8WSF8_APLCA Unreviewed; 236 AA. AC Q8WSF8; DT 01-MAR-2002, integrated into UniProtKB/TrEMBL. DT 01-MAR-2002, sequence version 1. DT 09-DEC-2015, entry version 80. DE SubName: Full=Soluble acetylcholine receptor {ECO:0000313|EMBL:AAL37251.1}; OS Aplysia californica (California sea hare). OC Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda; OC Heterobranchia; Euthyneura; Euopisthobranchia; Aplysiomorpha; OC Aplysioidea; Aplysiidae; Aplysia. OX NCBI_TaxID=6500 {ECO:0000313|EMBL:AAL37251.1}; RN [1] {ECO:0000213|PDB:2BYN, ECO:0000213|PDB:2BYP, ECO:0000213|PDB:2BYQ} RP X-RAY CRYSTALLOGRAPHY (2.02 ANGSTROMS) OF 18-236, DISULFIDE BONDS, AND RP GLYCOSYLATION AT ASN-91. RX PubMed=16193063; DOI=10.1038/sj.emboj.7600828; RA Hansen S.B., Sulzenbacher G., Huxford T., Marchot P., Taylor P., RA Bourne Y.; RT "Structures of Aplysia AChBP complexes with nicotinic agonists and RT antagonists reveal distinctive binding interfaces and conformations."; RL EMBO J. 24:3635-3646(2005). RN [2] {ECO:0000213|PDB:2BR7, ECO:0000213|PDB:2BR8} RP X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 20-236, AND DISULFIDE BONDS. RX PubMed=15951818; DOI=10.1038/nsmb951; RA Celie P.H., Kasheverov I.E., Mordvintsev D.Y., Hogg R.C., RA van Nierop P., van Elk R., van Rossum-Fikkert S.E., Zhmak M.N., RA Bertrand D., Tsetlin V., Sixma T.K., Smit A.B.; RT "Crystal structure of nicotinic acetylcholine receptor homolog AChBP RT in complex with an alpha-conotoxin PnIA variant."; RL Nat. Struct. Mol. Biol. 12:582-588(2005). RN [3] {ECO:0000213|PDB:2C9T} RP X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 20-236, AND DISULFIDE BONDS. RX PubMed=16505382; DOI=10.1073/pnas.0507889103; RA Ulens C., Hogg R.C., Celie P.H., Bertrand D., Tsetlin V., Smit A.B., RA Sixma T.K.; RT "Structural determinants of selective alpha-conotoxin binding to a RT nicotinic acetylcholine receptor homolog AChBP."; RL Proc. Natl. Acad. Sci. U.S.A. 103:3615-3620(2006). RN [4] {ECO:0000213|PDB:2UZ6} RP X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 20-236, AND DISULFIDE BONDS. RX PubMed=17660751; DOI=10.1038/sj.emboj.7601785; RA Dutertre S., Ulens C., Buttner R., Fish A., van Elk R., Kendel Y., RA Hopping G., Alewood P.F., Schroeder C., Nicke A., Smit A.B., RA Sixma T.K., Lewis R.J.; RT "AChBP-targeted alpha-conotoxin correlates distinct binding RT orientations with nAChR subtype selectivity."; RL EMBO J. 26:3858-3867(2007). RN [5] {ECO:0000213|PDB:2PGZ, ECO:0000213|PDB:2PH9} RP X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS) OF 18-236, DISULFIDE BONDS, AND RP GLYCOSYLATION AT ASN-91. RX PubMed=17481657; DOI=10.1016/j.jmb.2007.03.067; RA Hansen S.B., Taylor P.; RT "Galanthamine and non-competitive inhibitor binding to ACh-binding RT protein: evidence for a binding site on non-alpha-subunit interfaces RT of heteromeric neuronal nicotinic receptors."; RL J. Mol. Biol. 369:895-901(2007). RN [6] {ECO:0000213|PDB:3GUA} RP X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 18-225, AND DISULFIDE BONDS. RX PubMed=18940802; DOI=10.1074/jbc.C800194200; RA Hansen S.B., Wang H.L., Taylor P., Sine S.M.; RT "An ion selectivity filter in the extracellular domain of Cys-loop RT receptors reveals determinants for ion conductance."; RL J. Biol. Chem. 283:36066-36070(2008). RN [7] {ECO:0000213|PDB:3C79, ECO:0000213|PDB:3C84} RP X-RAY CRYSTALLOGRAPHY (1.94 ANGSTROMS) OF 18-236, AND DISULFIDE BONDS. RX PubMed=18477694; DOI=10.1073/pnas.0802197105; RA Talley T.T., Harel M., Hibbs R.E., Radic Z., Tomizawa M., Casida J.E., RA Taylor P.; RT "Atomic interactions of neonicotinoid agonists with AChBP: molecular RT recognition of the distinctive electronegative pharmacophore."; RL Proc. Natl. Acad. Sci. U.S.A. 105:7606-7611(2008). RN [8] {ECO:0000213|PDB:2WN9, ECO:0000213|PDB:2WNJ, ECO:0000213|PDB:2WNL} RP X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 18-236, DISULFIDE BONDS, AND RP GLYCOSYLATION AT ASN-91. RX PubMed=19696737; DOI=10.1038/emboj.2009.227; RA Hibbs R.E., Sulzenbacher G., Shi J., Talley T.T., Conrod S., Kem W.R., RA Taylor P., Marchot P., Bourne Y.; RT "Structural determinants for interaction of partial agonists with RT acetylcholine binding protein and neuronal alpha7 nicotinic RT acetylcholine receptor."; RL EMBO J. 28:3040-3051(2009). RN [9] {ECO:0000213|PDB:2W8F, ECO:0000213|PDB:2W8G, ECO:0000213|PDB:2Y7Y} RP X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 20-236, AND DISULFIDE BONDS. RX PubMed=19331415; DOI=10.1021/jm801400g; RA Ulens C., Akdemir A., Jongejan A., van Elk R., Bertrand S., RA Perrakis A., Leurs R., Smit A.B., Sixma T.K., Bertrand D., RA de Esch I.J.; RT "Use of acetylcholine binding protein in the search for novel alpha7 RT nicotinic receptor ligands. In silico docking, pharmacological RT screening, and X-ray analysis."; RL J. Med. Chem. 52:2372-2383(2009). RN [10] {ECO:0000213|PDB:4ZJS} RP X-RAY CRYSTALLOGRAPHY (2.23 ANGSTROMS) OF 48-77 AND 99-236, AND RP DISULFIDE BONDS. RX PubMed=19890000; DOI=10.1523/JNEUROSCI.2833-09.2009; RA Luo J., Taylor P., Losen M., de Baets M.H., Shelton G.D., RA Lindstrom J.; RT "Main immunogenic region structure promotes binding of conformation- RT dependent myasthenia gravis autoantibodies, nicotinic acetylcholine RT receptor conformation maturation, and agonist sensitivity."; RL J. Neurosci. 29:13898-13908(2009). RN [11] {ECO:0000213|PDB:2WZY, ECO:0000213|PDB:2X00} RP X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 18-236, AND DISULFIDE BONDS. RX PubMed=20224036; DOI=10.1073/pnas.0912372107; RA Bourne Y., Radic Z., Araoz R., Talley T.T., Benoit E., Servent D., RA Taylor P., Molgo J., Marchot P.; RT "Structural determinants in phycotoxins and AChBP conferring high RT affinity binding and nicotinic AChR antagonism."; RL Proc. Natl. Acad. Sci. U.S.A. 107:6076-6081(2010). RN [12] {ECO:0000213|PDB:3PEO} RP X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 18-236, AND DISULFIDE BONDS. RA Talley T.T., Harel M., Yamauchi G.J., Radic Z., Hansen S., Huxford T., RA Taylor P.W.; RT "The curare alkaloids: analyzing the poses of complexes with the RT acetylcholine binding protein in relation to structure and binding RT energetics."; RL Submitted (OCT-2010) to the PDB data bank. RN [13] {ECO:0000213|PDB:3PMZ} RP X-RAY CRYSTALLOGRAPHY (2.44 ANGSTROMS) OF 18-236 IN COMPLEX WITH RP MAGNESIUM, AND DISULFIDE BONDS. RA Talley T.T., Harel M., Yamauchi J.G., Radic Z., Hansen S., Huxford T., RA Taylor P.W.; RT "The Curare Alkaloids: Analyzing the Poses of Complexes with the RT Acetylcholine Binding Protein in Relation to Structure and Binding RT Energies."; RL Submitted (NOV-2010) to the PDB data bank. RN [14] {ECO:0000213|PDB:2XNT, ECO:0000213|PDB:2XNU, ECO:0000213|PDB:2XNV} RP X-RAY CRYSTALLOGRAPHY (2.44 ANGSTROMS), AND DISULFIDE BONDS. RX PubMed=21920761; DOI=10.1016/j.bmc.2011.08.028; RA Akdemir A., Rucktooa P., Jongejan A., Elk R.v., Bertrand S., RA Sixma T.K., Bertrand D., Smit A.B., Leurs R., de Graaf C., RA de Esch I.J.; RT "Acetylcholine binding protein (AChBP) as template for hierarchical in RT silico screening procedures to identify structurally novel ligands for RT the nicotinic receptors."; RL Bioorg. Med. Chem. 19:6107-6119(2011). RN [15] {ECO:0000213|PDB:2Y56, ECO:0000213|PDB:2Y57, ECO:0000213|PDB:2Y58} RP X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 20-236, AND DISULFIDE BONDS. RX PubMed=21322593; DOI=10.1021/ja110571r; RA Edink E., Rucktooa P., Retra K., Akdemir A., Nahar T., Zuiderveld O., RA van Elk R., Janssen E., van Nierop P., van Muijlwijk-Koezen J., RA Smit A.B., Sixma T.K., Leurs R., de Esch I.J.; RT "Fragment growing induces conformational changes in acetylcholine- RT binding protein: a structural and thermodynamic analysis."; RL J. Am. Chem. Soc. 133:5363-5371(2011). RN [16] {ECO:0000213|PDB:2XZ5, ECO:0000213|PDB:2XZ6} RP X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 20-236, AND DISULFIDE BONDS. RX PubMed=21115477; DOI=10.1074/jbc.M110.188730; RA Brams M., Gay E.A., Saez J.C., Guskov A., van Elk R., RA van der Schors R.C., Peigneur S., Tytgat J., Strelkov S.V., Smit A.B., RA Yakel J.L., Ulens C.; RT "Crystal structures of a cysteine-modified mutant in loop D of RT acetylcholine-binding protein."; RL J. Biol. Chem. 286:4420-4428(2011). RN [17] {ECO:0000213|PDB:3SH1, ECO:0000213|PDB:3SIO, ECO:0000213|PDB:3T4M} RP X-RAY CRYSTALLOGRAPHY (2.32 ANGSTROMS) OF 18-236, DISULFIDE BONDS, AND RP GLYCOSYLATION AT ASN-91. RX PubMed=22009746; DOI=10.1074/jbc.M111.286583; RA Nemecz A., Taylor P.; RT "Creating an alpha7 nicotinic acetylcholine recognition domain from RT the acetylcholine-binding protein: crystallographic and ligand RT selectivity analyses."; RL J. Biol. Chem. 286:42555-42565(2011). RN [18] {ECO:0000213|PDB:2XYS, ECO:0000213|PDB:2XYT} RP X-RAY CRYSTALLOGRAPHY (1.91 ANGSTROMS) OF 20-236, AND DISULFIDE BONDS. RX PubMed=21468359; DOI=10.1371/journal.pbio.1001034; RA Brams M., Pandya A., Kuzmin D., van Elk R., Krijnen L., Yakel J.L., RA Tsetlin V., Smit A.B., Ulens C.; RT "A structural and mutagenic blueprint for molecular recognition of RT strychnine and d-tubocurarine by different cys-loop receptors."; RL PLoS Biol. 9:e1001034-e1001034(2011). RN [19] {ECO:0000213|PDB:4DBM} RP X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 18-236, DISULFIDE BONDS, AND RP GLYCOSYLATION AT ASN-91. RX PubMed=22394239; DOI=10.1021/ja3001858; RA Grimster N.P., Stump B., Fotsing J.R., Weide T., Talley T.T., RA Yamauchi J.G., Nemecz A., Kim C., Ho K.Y., Sharpless K.B., Taylor P., RA Fokin V.V.; RT "Generation of candidate ligands for nicotinic acetylcholine receptors RT via in situ click chemistry with a soluble acetylcholine binding RT protein template."; RL J. Am. Chem. Soc. 134:6732-6740(2012). RN [20] {ECO:0000213|PDB:4AFT, ECO:0000213|PDB:4BQT} RP X-RAY CRYSTALLOGRAPHY (2.88 ANGSTROMS) OF 20-236, AND DISULFIDE BONDS. RX PubMed=22553201; DOI=10.1074/jbc.M112.360347; RA Rucktooa P., Haseler C.A., van Elk R., Smit A.B., Gallagher T., RA Sixma T.K.; RT "Structural characterization of binding mode of smoking cessation RT drugs to nicotinic acetylcholine receptors through study of ligand RT complexes with acetylcholine-binding protein."; RL J. Biol. Chem. 287:23283-23293(2012). RN [21] {ECO:0000213|PDB:4EZ1} RP X-RAY CRYSTALLOGRAPHY (2.49 ANGSTROMS) OF 18-236, AND DISULFIDE BONDS. RA Filchakova O.M., Talley T.T., Reger A.S., Kim C., Ho K., Han K., RA Taylor P., McIntosh J.M.; RT "Pairwise interaction of alpha-conotoxin BuIA Pro6 with the beta RT subunit of nicotinic acetylcholine receptor."; RL Submitted (MAY-2012) to the PDB data bank. RN [22] {ECO:0000213|PDB:4FRR} RP X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 18-225, AND DISULFIDE BONDS. RA Mukhopadhyay S., Mesecar A.D.; RT "X-ray structure of Acetylcholine binding protein from Aplysia RT californica in presence of 3-((S)-azetidin-2-ylmethoxy)-5-((1S,2R)-2- RT (2-methoxyethyl)cyclopropyl)pyridine."; RL Submitted (JUN-2012) to the PDB data bank. RN [23] {ECO:0000213|PDB:2YMD, ECO:0000213|PDB:2YME} RP X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) OF 20-231, DISULFIDE BONDS, AND RP GLYCOSYLATION AT ASN-91. RX PubMed=23196367; DOI=10.1038/embor.2012.189; RA Kesters D., Thompson A.J., Brams M., van Elk R., Spurny R., RA Geitmann M., Villalgordo J.M., Guskov A., Danielson U.H., Lummis S.C., RA Smit A.B., Ulens C.; RT "Structural basis of ligand recognition in 5-HT3 receptors."; RL EMBO Rep. 14:49-56(2013). RN [24] {ECO:0000213|PDB:4BFQ} RP X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 20-236, AND DISULFIDE BONDS. RX PubMed=23695669; DOI=10.1038/NCOMMS2900; RA Stornaiuolo M., De Kloe G.E., Rucktooa P., Fish A., van Elk R., RA Edink E.S., Bertrand D., Smit A.B., de Esch I.J., Sixma T.K.; RT "Assembly of a pi-pi stack of ligands in the binding site of an RT acetylcholine-binding protein."; RL Nat. Commun. 4:1875-1875(2013). RN [25] {ECO:0000213|PDB:4WV9} RP X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 18-224, AND DISULFIDE BONDS. RA Talley T.T.; RT "Crystal structure of acetylcholine binding protein (AChBP) from RT Aplysia Californica in complex with click chemistry compound."; RL Submitted (NOV-2014) to the PDB data bank. RN [26] {ECO:0000213|PDB:4XHE, ECO:0000213|PDB:4XK9} RP X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 18-225, AND DISULFIDE BONDS. RX PubMed=26004441; DOI=10.1016/j.str.2015.04.009; RA Bourne Y., Sulzenbacher G., Radic Z., Araoz R., Reynaud M., Benoit E., RA Zakarian A., Servent D., Molgo J., Taylor P., Marchot P.; RT "Marine Macrocyclic Imines, Pinnatoxins A and G: Structural RT Determinants and Functional Properties to Distinguish Neuronal alpha7 RT from Muscle alpha1(2)betagammadelta nAChRs."; RL Structure 23:1106-1115(2015). RN [27] {ECO:0000213|PDB:5AIN} RP X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 20-231, AND DISULFIDE BONDS. RA Price K.L., Lillestol R., Ulens C., Lummis S.C.; RT "Varenicline Interactions at the 5-Ht3 Receptor Ligand Binding Site RT are Revealed by 5-Htbp."; RL Submitted (FEB-2015) to the PDB data bank. RN [28] {ECO:0000213|PDB:4ZK4} RP X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 18-198 AND 215-236, AND RP DISULFIDE BONDS. RA Bobango J., Wu J., Talley T.T.; RT "Crystal structure of a chimeric acetylcholine binding protein from RT Aplysia californica (Ac-AChBP) containing loop C from the human alpha RT 3 nicotinic acetylcholine receptor in complex with 7-(5-isopropoxy- RT pyridin-3-yl)-1-methyl-1,7-diaza-spiro[4.4]nonane."; RL Submitted (APR-2015) to the PDB data bank. RN [29] {ECO:0000213|PDB:5BRX, ECO:0000213|PDB:5BW2} RP X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 18-236 AND DISULFIDE BONDS, RP AND X-RAY CRYSTALLOGRAPHY (2.27 ANGSTROMS) OF 18-236 AND DISULFIDE RP BONDS. RA Bobango J., Sankaran B., Park J.F., Wu J., Talley T.T.; RT "Comparisons of Binding Affinities for Neuronal Nicotinic Receptors RT (NNRs) and AChBPs."; RL Submitted (JUN-2015) to the PDB data bank. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF322877; AAL37251.1; -; mRNA. DR RefSeq; NP_001191488.1; NM_001204559.1. DR UniGene; Acl.89; -. DR PDB; 2BR7; X-ray; 3.00 A; A/B/C/D/E=20-236. DR PDB; 2BR8; X-ray; 2.40 A; A/B/C/D/E=20-236. DR PDB; 2BYN; X-ray; 2.02 A; A/B/C/D/E=18-236. DR PDB; 2BYP; X-ray; 2.07 A; A/B/C/D/E=18-225. DR PDB; 2BYQ; X-ray; 3.40 A; A/B/C/D/E=18-236. DR PDB; 2BYR; X-ray; 2.45 A; A/B/C/D/E/F/G/H/I/J=18-236. DR PDB; 2BYS; X-ray; 2.05 A; A/B/C/D/E/F/G/H/I/J=18-236. DR PDB; 2C9T; X-ray; 2.25 A; A/B/C/D/E/F/G/H/I/J=20-236. DR PDB; 2PGZ; X-ray; 1.76 A; A/B/C/D/E=18-236. DR PDB; 2PH9; X-ray; 2.88 A; A/B/C/D/E=18-236. DR PDB; 2UZ6; X-ray; 2.40 A; A/B/C/D/E/F/G/H/I/J=20-236. DR PDB; 2W8F; X-ray; 2.70 A; A/B/C/D/E/F/G/H/I/J=20-236. DR PDB; 2W8G; X-ray; 2.60 A; A/B/C/D/E=20-236. DR PDB; 2WN9; X-ray; 1.75 A; A/B/C/D/E=18-236. DR PDB; 2WNC; X-ray; 2.20 A; A/B/C/D/E=18-236. DR PDB; 2WNJ; X-ray; 1.80 A; A/B/C/D/E=18-236. DR PDB; 2WNL; X-ray; 2.70 A; A/B/C/D/E/F/G/H/I/J=18-236. DR PDB; 2WZY; X-ray; 2.51 A; A/B/C/D/E/F/G/H/I/J=18-236. DR PDB; 2X00; X-ray; 2.40 A; A/B/C/D/E=18-236. DR PDB; 2XNT; X-ray; 3.21 A; A/B/C/D/E/F/G/H/I/J=1-236. DR PDB; 2XNU; X-ray; 2.55 A; A/B/C/D/E=1-236. DR PDB; 2XNV; X-ray; 2.44 A; A/B/C/D/E/F/G/H/I/J=1-236. DR PDB; 2XYS; X-ray; 1.91 A; A/B/C/D/E=20-236. DR PDB; 2XYT; X-ray; 2.05 A; A/B/C/D/E/F/G/H/I/J=20-236. DR PDB; 2XZ5; X-ray; 2.80 A; A/B/C/D/E=20-236. DR PDB; 2XZ6; X-ray; 3.14 A; A/B/C/D/E/F/G/H/I/J=20-236. DR PDB; 2Y54; X-ray; 3.65 A; A/B/C/D/E=20-236. DR PDB; 2Y56; X-ray; 3.59 A; A/B/C/D/E=20-236. DR PDB; 2Y57; X-ray; 3.30 A; A/B/C/D/E=20-236. DR PDB; 2Y58; X-ray; 3.25 A; A/B/C/D/E=20-236. DR PDB; 2Y7Y; X-ray; 1.90 A; A/B/C/D/E=20-236. DR PDB; 2YMD; X-ray; 1.96 A; A/B/C/D/E/F/G/H/I/J=20-231. DR PDB; 2YME; X-ray; 2.40 A; A/B/C/D/E/F/G/H/I/J=20-224. DR PDB; 3C79; X-ray; 2.48 A; A/B/C/D/E=18-236. DR PDB; 3C84; X-ray; 1.94 A; A/B/C/D/E=18-236. DR PDB; 3GUA; X-ray; 3.10 A; A/B/C/D/E/F/G/H/I/J=18-225. DR PDB; 3PEO; X-ray; 2.10 A; A/B/C/D/E/F/G/H/I/J=18-236. DR PDB; 3PMZ; X-ray; 2.44 A; A/B/C/D/E/F/G/H/I/J=18-236. DR PDB; 3SH1; X-ray; 2.90 A; A/B/C/D/E/F/G/H/I/J=18-236. DR PDB; 3SIO; X-ray; 2.32 A; A/B/C/D/E/F/G/H/I/J=18-236. DR PDB; 3T4M; X-ray; 3.00 A; A/B/C/D/E/F/G/H/I/J=18-236. DR PDB; 4AFT; X-ray; 3.20 A; A/B/C/D/E=20-236. DR PDB; 4BFQ; X-ray; 2.40 A; A/B/C/D/E=20-236. DR PDB; 4BQT; X-ray; 2.88 A; A/B/C/D/E=20-236. DR PDB; 4DBM; X-ray; 2.30 A; A/B/C/D/E=18-236. DR PDB; 4EZ1; X-ray; 2.49 A; A/B/C/D/E=18-236. DR PDB; 4FRR; X-ray; 2.20 A; A/B/C/D/E/F/G/H/I/J=18-225. DR PDB; 4WV9; X-ray; 2.00 A; A/B/C/D/E=18-224. DR PDB; 4XHE; X-ray; 1.90 A; A/B/C/D/E/F/G/H/I/J=18-225. DR PDB; 4XK9; X-ray; 2.20 A; A/B/C/D/E/F/G/H/I/J=18-236. DR PDB; 4ZJS; X-ray; 2.23 A; A/B/C/D/E=48-77, A/B/C/D/E=99-236. DR PDB; 4ZK4; X-ray; 1.90 A; A/B/C/D/E=18-198, A/B/C/D/E=215-236. DR PDB; 5AIN; X-ray; 2.30 A; A/B/C/D/E=20-231. DR PDB; 5BRX; X-ray; 2.05 A; A/B/C/D/E/F/G/H/I/J=18-236. DR PDB; 5BW2; X-ray; 2.27 A; A/B/C/D/E=18-236. DR PDBsum; 2BR7; -. DR PDBsum; 2BR8; -. DR PDBsum; 2BYN; -. DR PDBsum; 2BYP; -. DR PDBsum; 2BYQ; -. DR PDBsum; 2BYR; -. DR PDBsum; 2BYS; -. DR PDBsum; 2C9T; -. DR PDBsum; 2PGZ; -. DR PDBsum; 2PH9; -. DR PDBsum; 2UZ6; -. DR PDBsum; 2W8F; -. DR PDBsum; 2W8G; -. DR PDBsum; 2WN9; -. DR PDBsum; 2WNC; -. DR PDBsum; 2WNJ; -. DR PDBsum; 2WNL; -. DR PDBsum; 2WZY; -. DR PDBsum; 2X00; -. DR PDBsum; 2XNT; -. DR PDBsum; 2XNU; -. DR PDBsum; 2XNV; -. DR PDBsum; 2XYS; -. DR PDBsum; 2XYT; -. DR PDBsum; 2XZ5; -. DR PDBsum; 2XZ6; -. DR PDBsum; 2Y54; -. DR PDBsum; 2Y56; -. DR PDBsum; 2Y57; -. DR PDBsum; 2Y58; -. DR PDBsum; 2Y7Y; -. DR PDBsum; 2YMD; -. DR PDBsum; 2YME; -. DR PDBsum; 3C79; -. DR PDBsum; 3C84; -. DR PDBsum; 3GUA; -. DR PDBsum; 3PEO; -. DR PDBsum; 3PMZ; -. DR PDBsum; 3SH1; -. DR PDBsum; 3SIO; -. DR PDBsum; 3T4M; -. DR PDBsum; 4AFT; -. DR PDBsum; 4BFQ; -. DR PDBsum; 4BQT; -. DR PDBsum; 4DBM; -. DR PDBsum; 4EZ1; -. DR PDBsum; 4FRR; -. DR PDBsum; 4WV9; -. DR PDBsum; 4XHE; -. DR PDBsum; 4XK9; -. DR PDBsum; 4ZJS; -. DR PDBsum; 4ZK4; -. DR PDBsum; 5AIN; -. DR PDBsum; 5BRX; -. DR PDBsum; 5BW2; -. DR ProteinModelPortal; Q8WSF8; -. DR SMR; Q8WSF8; 18-226. DR DIP; DIP-46103N; -. DR MINT; MINT-7300724; -. DR BindingDB; Q8WSF8; -. DR ChEMBL; CHEMBL1944497; -. DR GeneID; 100533247; -. DR EvolutionaryTrace; Q8WSF8; -. DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro. DR GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR Gene3D; 2.70.170.10; -; 1. DR InterPro; IPR006202; Neur_chan_lig-bd. DR InterPro; IPR006201; Neur_channel. DR PANTHER; PTHR18945; PTHR18945; 1. DR Pfam; PF02931; Neur_chan_LBD; 1. DR SUPFAM; SSF63712; SSF63712; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0000213|PDB:2BR7, ECO:0000213|PDB:2BR8, KW ECO:0000213|PDB:2BYN, ECO:0000213|PDB:2BYP}; KW Magnesium {ECO:0000213|PDB:2WNL, ECO:0000213|PDB:3C84, KW ECO:0000213|PDB:3PMZ, ECO:0000213|PDB:3SH1}; KW Metal-binding {ECO:0000213|PDB:2WNL, ECO:0000213|PDB:3C84, KW ECO:0000213|PDB:3PMZ, ECO:0000213|PDB:3SH1}; KW Receptor {ECO:0000313|EMBL:AAL37251.1}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 236 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5004316614. FT DOMAIN 35 222 Neur_chan_LBD. {ECO:0000259|Pfam: FT PF02931}. FT METAL 167 167 Magnesium 1. {ECO:0000213|PDB:3PMZ}. FT METAL 167 167 Magnesium 2. {ECO:0000213|PDB:3PMZ}. FT METAL 170 170 Magnesium 2. {ECO:0000213|PDB:3PMZ}. FT METAL 210 210 Magnesium 1. {ECO:0000213|PDB:3PMZ}. FT CARBOHYD 91 91 N-linked (GlcNAc...). {ECO:0000213|PDB: FT 2BYN, ECO:0000213|PDB:2BYP, FT ECO:0000213|PDB:2PGZ}. FT /FTId=CAR_5005390077. FT DISULFID 144 157 {ECO:0000213|PDB:2BR7, ECO:0000213|PDB: FT 2BR8, ECO:0000213|PDB:2BYN}. FT DISULFID 207 208 {ECO:0000213|PDB:2BR7, ECO:0000213|PDB: FT 2BR8, ECO:0000213|PDB:2BYN}. SQ SEQUENCE 236 AA; 26568 MW; 6D0DE487C46707BE CRC64; MLVSVYLALL VACVGQAHSQ ANLMRLKSDL FNRSPMYPGP TKDDPLTVTL GFTLQDIVKA DSSTNEVDLV YYEQQRWKLN SLMWDPNEYG NITDFRTSAA DIWTPDITAY SSTRPVQVLS PQIAVVTHDG SVMFIPAQRL SFMCDPTGVD SEEGATCAVK FGSWVYSGFE IDLKTDTDQV DLSSYYASSK YEILSATQTR QVQHYSCCPE PYIDVNLVVK FRERRAGNGF FRNLFD //