ID MCU5_ARATH Reviewed; 293 AA. AC Q8VYR0; Q9FVU1; DT 26-NOV-2014, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2002, sequence version 1. DT 18-JUL-2018, entry version 94. DE RecName: Full=Calcium uniporter protein 5, mitochondrial; DE Flags: Precursor; GN OrderedLocusNames=At1g57610 {ECO:0000312|Araport:AT1G57610}; GN ORFNames=T8L23.8 {ECO:0000312|EMBL:AAG50752.1}; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; OC Arabidopsis. OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AAL49777.1}; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX PubMed=11130712; DOI=10.1038/35048500; RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., RA White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., RA Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., RA Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., RA Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., RA Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., RA Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., RA Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., RA Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., RA Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., RA Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., RA Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., RA Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., RA Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., RA Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.; RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis RT thaliana."; RL Nature 408:816-820(2000). RN [2] RP GENOME REANNOTATION. RC STRAIN=cv. Columbia; RX PubMed=27862469; DOI=10.1111/tpj.13415; RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S., RA Town C.D.; RT "Araport11: a complete reannotation of the Arabidopsis thaliana RT reference genome."; RL Plant J. 89:789-804(2017). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Columbia; RX PubMed=14593172; DOI=10.1126/science.1088305; RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., RA Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., RA Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., RA Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., RA Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., RA Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., RA Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., RA Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., RA Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., RA Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., RA Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., RA Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.; RT "Empirical analysis of transcriptional activity in the Arabidopsis RT genome."; RL Science 302:842-846(2003). RN [4] RP GENE FAMILY, AND REVIEW. RX PubMed=22200666; DOI=10.1093/jxb/err394; RA Stael S., Wurzinger B., Mair A., Mehlmer N., Vothknecht U.C., RA Teige M.; RT "Plant organellar calcium signalling: an emerging field."; RL J. Exp. Bot. 63:1525-1542(2012). CC -!- FUNCTION: Mitochondrial inner membrane calcium uniporter that CC mediates calcium uptake into mitochondria. Constitutes a pore- CC forming and calcium-conducting subunit. Mitochondrial calcium CC homeostasis plays key roles in cellular physiology and regulates CC cell bioenergetics, cytoplasmic calcium signals and activation of CC cell death pathways. {ECO:0000250|UniProtKB:Q8NE86}. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000250|UniProtKB:Q8NE86}; Multi-pass membrane protein CC {ECO:0000250|UniProtKB:Q8NE86}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=1; CC Comment=A number of isoforms are produced. According to EST CC sequences.; CC Name=1; CC IsoId=Q8VYR0-1; Sequence=Displayed; CC -!- SIMILARITY: Belongs to the MCU (TC 1.A.77) family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAG50752.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC079733; AAG50752.1; ALT_INIT; Genomic_DNA. DR EMBL; CP002684; AEE33441.1; -; Genomic_DNA. DR EMBL; CP002684; AEE33442.1; -; Genomic_DNA. DR EMBL; AY070082; AAL49777.1; -; mRNA. DR PIR; C96610; C96610. DR RefSeq; NP_176074.2; NM_104558.4. [Q8VYR0-1] DR RefSeq; NP_974043.1; NM_202314.3. [Q8VYR0-1] DR UniGene; At.28402; -. DR STRING; 3702.AT1G57610.1; -. DR PaxDb; Q8VYR0; -. DR EnsemblPlants; AT1G57610.1; AT1G57610.1; AT1G57610. [Q8VYR0-1] DR EnsemblPlants; AT1G57610.2; AT1G57610.2; AT1G57610. [Q8VYR0-1] DR GeneID; 842137; -. DR Gramene; AT1G57610.1; AT1G57610.1; AT1G57610. [Q8VYR0-1] DR Gramene; AT1G57610.2; AT1G57610.2; AT1G57610. [Q8VYR0-1] DR KEGG; ath:AT1G57610; -. DR Araport; AT1G57610; -. DR TAIR; locus:2206510; AT1G57610. DR eggNOG; KOG2966; Eukaryota. DR eggNOG; ENOG410Y3YU; LUCA. DR HOGENOM; HOG000238395; -. DR InParanoid; Q8VYR0; -. DR KO; K20858; -. DR OMA; EFTYEAL; -. DR OrthoDB; EOG09360K4O; -. DR PhylomeDB; Q8VYR0; -. DR Reactome; R-ATH-8949215; Mitochondrial calcium ion transport. DR PRO; PR:Q8VYR0; -. DR Proteomes; UP000006548; Chromosome 1. DR ExpressionAtlas; Q8VYR0; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW. DR GO; GO:0015292; F:uniporter activity; IBA:GO_Central. DR InterPro; IPR006769; MCU_C. DR InterPro; IPR039055; MCU_fam. DR PANTHER; PTHR13462; PTHR13462; 1. DR Pfam; PF04678; MCU; 1. PE 2: Evidence at transcript level; KW Alternative splicing; Calcium; Calcium channel; Calcium transport; KW Complete proteome; Ion channel; Ion transport; Membrane; KW Mitochondrion; Mitochondrion inner membrane; Reference proteome; KW Transit peptide; Transmembrane; Transmembrane helix; Transport. FT TRANSIT 1 33 Mitochondrion. {ECO:0000255}. FT CHAIN 34 293 Calcium uniporter protein 5, FT mitochondrial. FT /FTId=PRO_0000431374. FT TRANSMEM 168 188 Helical; Name=1. {ECO:0000255}. FT TRANSMEM 198 218 Helical; Name=2. {ECO:0000255}. FT COMPBIAS 261 266 Poly-Ser. {ECO:0000255}. SQ SEQUENCE 293 AA; 33685 MW; 3F599D18C29038D7 CRC64; MWSVMGLVRR TAMSSTVNKA SPVRSLLGGF RCLNVESKEE DEKKDMTVLE AKKLMRLVNV EDMKKKLIGM GDKEMVTYTT LIEASQGLGI ARSLDEAHAF ARVLDDAGVI LIFRDKVYLH PHKVVDLIRK AVPLGLNPDD ELIREEFDKM RSMKEEIDVL AHQQVRKILW GGLGYSVVQI GIFVRLTFWE FSWDVMEPIT FFTTATGIIV GYAYFLMTSR DPTYQDFMKR LFLSRQRKLL KSHKFDAERF KELENKWKIT SCSSSSCHAN ASIRNRVGVD LDLEDSLQSH HRD //