ID Q8VIE3_RAT Unreviewed; 359 AA. AC Q8VIE3; DT 01-MAR-2002, integrated into UniProtKB/TrEMBL. DT 01-MAR-2002, sequence version 1. DT 16-MAY-2012, entry version 55. DE SubName: Full=Cyclic nucleotide phosphodiesterase 7B3; DE EC=3.1.4.17; DE SubName: Full=Phosphodiesterase 7B, isoform CRA_a; GN Name=Pde7b; Synonyms=RNPDE7B; ORFNames=rCG_57377; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Testis; RA Sasaki T., Kotera J., Omori K.; RT "Novel alternative splice variants of rat PDE7B."; RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN; RX PubMed=15632090; DOI=10.1101/gr.2889405; RA Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., RA Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., RA Istrail S., Li P., Sutton G.; RT "Gene and alternative splicing annotation with AIR."; RL Genome Res. 15:54-66(2005). RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN; RA Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., RA Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., RA Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., RA Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., RA Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. CC -!- COFACTOR: Binds 2 divalent metal cations per subunit. Site 1 may CC preferentially bind zinc ions, while site 2 has a preference for CC magnesium and/or manganese ions (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB057410; BAB79638.1; -; mRNA. DR EMBL; CH473994; EDL93804.1; -; Genomic_DNA. DR IPI; IPI00382090; -. DR UniGene; Rn.207215; -. DR HSSP; Q08499; 1OYN. DR SMR; Q8VIE3; 13-329. DR STRING; Q8VIE3; -. DR UCSC; AB057410; rat. DR HOGENOM; HOG000220881; -. DR HOVERGEN; HBG053543; -. DR InParanoid; Q8VIE3; -. DR ArrayExpress; Q8VIE3; -. DR Genevestigator; Q8VIE3; -. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR Gene3D; G3DSA:1.10.1300.10; PDEase_catalytic_dom; 1. DR InterPro; IPR003607; HD/PDEase_dom. DR InterPro; IPR023088; PDEase. DR InterPro; IPR002073; PDEase_catalytic_dom. DR InterPro; IPR023174; PDEase_CS. DR Pfam; PF00233; PDEase_I; 1. DR PRINTS; PR00387; PDIESTERASE1. DR SMART; SM00471; HDc; 1. DR PROSITE; PS00126; PDEASE_I; 1. PE 2: Evidence at transcript level; KW Hydrolase; Metal-binding. SQ SEQUENCE 359 AA; 41456 MW; 0FF72792737CE48A CRC64; MTPQAPLHLL DEDYLGQARH MLSKVGMWDF DIFLFDRLTN GNSLVTLLCH LFNSHGLIHH FKLDMVTLHR FLVMVQEDYH GHNPYHNAVH AADVTQAMHC YLKEPKLASF LTPLDIMLGL LAAAAHDVDH PGVNQPFLIK TNHHLANLYQ NMSVLENHHW RSTIGMLRES RLLAHLPKEM TQDIEQQLGS LILATDINRQ NEFLTRLKAH LHNKDLRLEN IQDRHFMLQI ALKCADICNP CRIWEMSKQW SERVCEEFYR QGDLEQKFEL EISPLCNQQK DSIPSIQIGF MTYIVEPLFR EWARFTGNST LSESMLNHLA HNKAQWKSLL SNQHRRRGSG QDPAGTAPET LEQTEGATP //