ID Q8VIE3_RAT Unreviewed; 359 AA. AC Q8VIE3; DT 01-MAR-2002, integrated into UniProtKB/TrEMBL. DT 01-MAR-2002, sequence version 1. DT 12-OCT-2022, entry version 115. DE SubName: Full=Cyclic nucleotide phosphodiesterase 7B3 {ECO:0000313|EMBL:BAB79638.1}; DE EC=3.1.4.17 {ECO:0000313|EMBL:BAB79638.1}; DE SubName: Full=Phosphodiesterase 7B, isoform CRA_a {ECO:0000313|EMBL:EDL93804.1}; GN Name=Pde7b {ECO:0000313|EMBL:EDL93804.1, ECO:0000313|RGD:621016}; GN Synonyms=RNPDE7B {ECO:0000313|EMBL:BAB79638.1}; GN ORFNames=rCG_57377 {ECO:0000313|EMBL:EDL93804.1}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:BAB79638.1}; RN [1] {ECO:0000313|EMBL:BAB79638.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Testis {ECO:0000313|EMBL:BAB79638.1}; RA Sasaki T., Kotera J., Omori K.; RT "Novel alternative splice variants of rat PDE7B."; RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:EDL93804.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDL93804.1}; RX PubMed=15632090; DOI=10.1101/gr.2889405; RA Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., RA Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., RA Istrail S., Li P., Sutton G.; RT "Gene and alternative splicing annotation with AIR."; RL Genome Res. 15:54-66(2005). RN [3] {ECO:0000313|EMBL:EDL93804.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDL93804.1}; RA Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., RA Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., RA Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F., RA Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., RA Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB057410; BAB79638.1; -; mRNA. DR EMBL; CH473994; EDL93804.1; -; Genomic_DNA. DR RefSeq; XP_008756814.1; XM_008758592.2. DR GeneID; 140929; -. DR CTD; 27115; -. DR RGD; 621016; Pde7b. DR OrthoDB; 904682at2759; -. DR GO; GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IDA:RGD. DR GO; GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IBA:GO_Central. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0019933; P:cAMP-mediated signaling; ISO:RGD. DR GO; GO:0007165; P:signal transduction; IBA:GO_Central. DR CDD; cd00077; HDc; 1. DR Gene3D; 1.10.1300.10; -; 1. DR InterPro; IPR003607; HD/PDEase_dom. DR InterPro; IPR023088; PDEase. DR InterPro; IPR002073; PDEase_catalytic_dom. DR InterPro; IPR036971; PDEase_catalytic_dom_sf. DR InterPro; IPR023174; PDEase_CS. DR Pfam; PF00233; PDEase_I; 1. DR PRINTS; PR00387; PDIESTERASE1. DR SMART; SM00471; HDc; 1. DR PROSITE; PS00126; PDEASE_I_1; 1. DR PROSITE; PS51845; PDEASE_I_2; 1. PE 2: Evidence at transcript level; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:BAB79638.1}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, KW ECO:0000256|PIRSR:PIRSR623088-3}. FT DOMAIN 10..333 FT /note="PDEase" FT /evidence="ECO:0000259|PROSITE:PS51845" FT REGION 333..359 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT ACT_SITE 86 FT /note="Proton donor" FT /evidence="ECO:0000256|PIRSR:PIRSR623088-1" FT BINDING 86..90 FT /ligand="AMP" FT /ligand_id="ChEBI:CHEBI:456215" FT /evidence="ECO:0000256|PIRSR:PIRSR623088-2" FT BINDING 90 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="1" FT /evidence="ECO:0000256|PIRSR:PIRSR623088-3" FT BINDING 126 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="1" FT /evidence="ECO:0000256|PIRSR:PIRSR623088-3" FT BINDING 127 FT /ligand="AMP" FT /ligand_id="ChEBI:CHEBI:456215" FT /evidence="ECO:0000256|PIRSR:PIRSR623088-2" FT BINDING 127 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="2" FT /evidence="ECO:0000256|PIRSR:PIRSR623088-3" FT BINDING 127 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="1" FT /evidence="ECO:0000256|PIRSR:PIRSR623088-3" FT BINDING 236 FT /ligand="AMP" FT /ligand_id="ChEBI:CHEBI:456215" FT /evidence="ECO:0000256|PIRSR:PIRSR623088-2" FT BINDING 236 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="1" FT /evidence="ECO:0000256|PIRSR:PIRSR623088-3" FT BINDING 287 FT /ligand="AMP" FT /ligand_id="ChEBI:CHEBI:456215" FT /evidence="ECO:0000256|PIRSR:PIRSR623088-2" SQ SEQUENCE 359 AA; 41456 MW; 0FF72792737CE48A CRC64; MTPQAPLHLL DEDYLGQARH MLSKVGMWDF DIFLFDRLTN GNSLVTLLCH LFNSHGLIHH FKLDMVTLHR FLVMVQEDYH GHNPYHNAVH AADVTQAMHC YLKEPKLASF LTPLDIMLGL LAAAAHDVDH PGVNQPFLIK TNHHLANLYQ NMSVLENHHW RSTIGMLRES RLLAHLPKEM TQDIEQQLGS LILATDINRQ NEFLTRLKAH LHNKDLRLEN IQDRHFMLQI ALKCADICNP CRIWEMSKQW SERVCEEFYR QGDLEQKFEL EISPLCNQQK DSIPSIQIGF MTYIVEPLFR EWARFTGNST LSESMLNHLA HNKAQWKSLL SNQHRRRGSG QDPAGTAPET LEQTEGATP //