ID Q8VFT4_MOUSE Unreviewed; 313 AA. AC Q8VFT4; DT 01-MAR-2002, integrated into UniProtKB/TrEMBL. DT 01-MAR-2002, sequence version 1. DT 12-AUG-2020, entry version 141. DE RecName: Full=Olfactory receptor {ECO:0000256|RuleBase:RU363047}; GN Name=Olfr734 {ECO:0000313|EMBL:AAI41030.1, GN ECO:0000313|Ensembl:ENSMUSP00000057376, ECO:0000313|MGI:MGI:3030568}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAL61095.1}; RN [1] {ECO:0000313|EMBL:AAL61095.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11875048; DOI=10.1093/hmg/11.5.535; RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RT "Different evolutionary processes shaped the mouse and human olfactory RT receptor gene families."; RL Hum. Mol. Genet. 11:535-546(2002). RN [2] {ECO:0000313|EMBL:AAL61095.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11802173; DOI=10.1038/nn800; RA Zhang X., Firestein S.; RT "The olfactory receptor gene superfamily of the mouse."; RL Nat. Neurosci. 5:124-133(2002). RN [3] {ECO:0000313|EMBL:AAL61095.1} RP NUCLEOTIDE SEQUENCE. RA Adams M.; RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:AAP71197.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71; RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A., RA Walker M., Williams E.M., Trask B.J.; RT "Odorant receptor expressed sequence tags demonstrate olfactory expression RT of over 400 genes, extensive alternate splicing and unequal expression RT levels."; RL Genome Biol. 4:R71.1-R71.13(2003). RN [5] {ECO:0000313|EMBL:AAP71197.1} RP NUCLEOTIDE SEQUENCE. RA Sanders K.; RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:AAI41030.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain {ECO:0000313|EMBL:AAI41030.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] {ECO:0000313|Ensembl:ENSMUSP00000057376, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000057376, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [8] {ECO:0000313|Ensembl:ENSMUSP00000057376} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000057376}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [9] {ECO:0000313|Ensembl:ENSMUSP00000150732} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000150732}; RG Ensembl; RL Submitted (DEC-2016) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651, CC ECO:0000256|RuleBase:RU363047}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363047}. CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000256|RuleBase:RU000688}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC135188; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC141029; AAI41030.1; -; mRNA. DR EMBL; AY073432; AAL61095.1; -; Genomic_DNA. DR EMBL; AY317859; AAP71197.1; -; Genomic_DNA. DR RefSeq; NP_666875.1; NM_146664.1. DR STRING; 10090.ENSMUSP00000057376; -. DR Ensembl; ENSMUST00000050928; ENSMUSP00000057376; ENSMUSG00000045306. DR Ensembl; ENSMUST00000217152; ENSMUSP00000150732; ENSMUSG00000045306. DR GeneID; 258658; -. DR KEGG; mmu:258658; -. DR UCSC; uc007tkx.1; mouse. DR CTD; 258658; -. DR MGI; MGI:3030568; Olfr734. DR eggNOG; ENOG502SKDS; Eukaryota. DR GeneTree; ENSGT00940000163142; -. DR HOGENOM; CLU_012526_8_1_1; -. DR KO; K04257; -. DR OMA; IICTIRL; -. DR OrthoDB; 980902at2759; -. DR TreeFam; TF338273; -. DR Reactome; R-MMU-381753; Olfactory Signaling Pathway. DR BioGRID-ORCS; 258658; 1 hit in 12 CRISPR screens. DR Proteomes; UP000000589; Chromosome 14. DR Bgee; ENSMUSG00000045306; Expressed in olfactory epithelium and 3 other tissues. DR GO; GO:0016021; C:integral component of membrane; ISA:MGI. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI. DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR Pfam; PF13853; 7tm_4; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, KW ECO:0000256|RuleBase:RU363047}; KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040, KW ECO:0000256|RuleBase:RU000688}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363047}; KW Olfaction {ECO:0000256|ARBA:ARBA00022725, ECO:0000256|RuleBase:RU363047}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688, KW ECO:0000313|EMBL:AAL61095.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606, KW ECO:0000256|RuleBase:RU363047}; KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU000688}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU363047}. FT TRANSMEM 25..47 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363047" FT TRANSMEM 59..78 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363047" FT TRANSMEM 98..120 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363047" FT TRANSMEM 140..164 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363047" FT TRANSMEM 200..221 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363047" FT TRANSMEM 242..261 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363047" FT TRANSMEM 273..291 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU363047" FT DOMAIN 41..289 FT /note="G_PROTEIN_RECEP_F1_2" FT /evidence="ECO:0000259|PROSITE:PS50262" SQ SEQUENCE 313 AA; 35601 MW; 5A73BDE2898D6A5F CRC64; MEPANDTTVT EFILTGLSQT REVQLVLFVI FLSFYLFILP VNILIICTIR LDSHLSSPMY FLLANLAFLD IWYSSITAPK MLVDFFVERK IISFGGCIAQ LFFLHFVGAS EMFLLTVMAF DRYAAICRPL HYATIMNRRL CCILVALSWT GGFVHSIIQV ALIVRLPFCG PNELDNYFCD ITQVVRIACA NTFLEEMVMI FSSGLISVVC FIALLMSYAF LLTMLKKHSS SGESTSRAIS TCYSHITIVV LMFGPSIYIY ARPFDSFSLD KVVSVFHTVI FPLLNPIIYT LRNKEVKAAM RKLVNRYIFC KEK //