ID Q8VFT4_MOUSE Unreviewed; 313 AA. AC Q8VFT4; DT 01-MAR-2002, integrated into UniProtKB/TrEMBL. DT 01-MAR-2002, sequence version 1. DT 27-MAY-2015, entry version 104. DE RecName: Full=Olfactory receptor {ECO:0000256|RuleBase:RU000688}; GN Name=Olfr734 {ECO:0000313|EMBL:AAI41030.1, GN ECO:0000313|Ensembl:ENSMUSP00000057376, ECO:0000313|MGI:MGI:3030568}; GN ORFNames=mCG_66458 {ECO:0000313|EMBL:EDL20804.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] {ECO:0000313|EMBL:AAL61095.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11875048; DOI=10.1093/hmg/11.5.535; RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L., RA Trask B.J.; RT "Different evolutionary processes shaped the mouse and human olfactory RT receptor gene families."; RL Hum. Mol. Genet. 11:535-546(2002). RN [2] {ECO:0000313|EMBL:AAL61095.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11802173; DOI=10.1038/nn800; RA Zhang X., Firestein S.; RT "The olfactory receptor gene superfamily of the mouse."; RL Nat. Neurosci. 5:124-133(2002). RN [3] {ECO:0000313|EMBL:EDL20804.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL20804.1}; RX PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and RT the human genome."; RL Science 296:1661-1671(2002). RN [4] {ECO:0000313|EMBL:AAL61095.1} RP NUCLEOTIDE SEQUENCE. RA Adams M.; RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:AAP71197.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71; RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A., RA Walker M., Williams E.M., Trask B.J.; RT "Odorant receptor expressed sequence tags demonstrate olfactory RT expression of over 400 genes, extensive alternate splicing and unequal RT expression levels."; RL Genome Biol. 4:R71.1-R71.13(2003). RN [6] {ECO:0000313|EMBL:AAP71197.1} RP NUCLEOTIDE SEQUENCE. RA Sanders K.; RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:AAI41030.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain {ECO:0000313|EMBL:AAI41030.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] {ECO:0000313|EMBL:EDL20804.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL20804.1}; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|Ensembl:ENSMUSP00000057376, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000057376, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [10] {ECO:0000313|Ensembl:ENSMUSP00000057376} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000057376}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane CC {ECO:0000256|SAAS:SAAS00132828}; Multi-pass membrane protein CC {ECO:0000256|SAAS:SAAS00132828}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000256|RuleBase:RU000688}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC135188; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC141029; AAI41030.1; -; mRNA. DR EMBL; AY073432; AAL61095.1; -; Genomic_DNA. DR EMBL; AY317859; AAP71197.1; -; Genomic_DNA. DR EMBL; CH466605; EDL20804.1; -; Genomic_DNA. DR RefSeq; NP_666875.1; NM_146664.1. DR UniGene; Mm.377621; -. DR ProteinModelPortal; Q8VFT4; -. DR SMR; Q8VFT4; 26-300. DR STRING; 10090.ENSMUSP00000057376; -. DR Ensembl; ENSMUST00000050928; ENSMUSP00000057376; ENSMUSG00000045306. DR GeneID; 258658; -. DR KEGG; mmu:258658; -. DR UCSC; uc007tkx.1; mouse. DR CTD; 258658; -. DR MGI; MGI:3030568; Olfr734. DR eggNOG; NOG67996; -. DR GeneTree; ENSGT00760000119104; -. DR HOGENOM; HOG000041362; -. DR HOVERGEN; HBG017625; -. DR KO; K04257; -. DR OMA; VNRYILC; -. DR OrthoDB; EOG71K63J; -. DR PhylomeDB; Q8VFT4; -. DR TreeFam; TF338273; -. DR Reactome; REACT_325400; Olfactory Signaling Pathway. DR NextBio; 390215; -. DR PRO; PR:Q8VFT4; -. DR Proteomes; UP000000589; Chromosome 14. DR Genevestigator; Q8VFT4; -. DR GO; GO:0016021; C:integral component of membrane; ISA:MGI. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central. DR GO; GO:0050907; P:detection of chemical stimulus involved in sensory perception; IBA:GO_Central. DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; ISA:GOC. DR GO; GO:0007186; P:G-protein coupled receptor signaling pathway; ISA:MGI. DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane {ECO:0000256|SAAS:SAAS00132830}; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688, KW ECO:0000256|SAAS:SAAS00132817}; KW Membrane {ECO:0000256|SAAS:SAAS00132823}; KW Olfaction {ECO:0000256|SAAS:SAAS00132820}; KW Receptor {ECO:0000256|RuleBase:RU000688, KW ECO:0000256|SAAS:SAAS00132805}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Sensory transduction {ECO:0000256|SAAS:SAAS00132815}; KW Transducer {ECO:0000256|RuleBase:RU000688, KW ECO:0000256|SAAS:SAAS00132822}; KW Transmembrane {ECO:0000256|RuleBase:RU000688, KW ECO:0000256|SAAS:SAAS00132812}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00132821}. SQ SEQUENCE 313 AA; 35601 MW; 5A73BDE2898D6A5F CRC64; MEPANDTTVT EFILTGLSQT REVQLVLFVI FLSFYLFILP VNILIICTIR LDSHLSSPMY FLLANLAFLD IWYSSITAPK MLVDFFVERK IISFGGCIAQ LFFLHFVGAS EMFLLTVMAF DRYAAICRPL HYATIMNRRL CCILVALSWT GGFVHSIIQV ALIVRLPFCG PNELDNYFCD ITQVVRIACA NTFLEEMVMI FSSGLISVVC FIALLMSYAF LLTMLKKHSS SGESTSRAIS TCYSHITIVV LMFGPSIYIY ARPFDSFSLD KVVSVFHTVI FPLLNPIIYT LRNKEVKAAM RKLVNRYIFC KEK //