ID Q8VEK8_MOUSE Unreviewed; 93 AA. AC Q8VEK8; DT 01-MAR-2002, integrated into UniProtKB/TrEMBL. DT 01-MAR-2002, sequence version 1. DT 12-AUG-2020, entry version 89. DE RecName: Full=Matrix Gla protein {ECO:0000256|ARBA:ARBA00017145, ECO:0000256|RuleBase:RU361261}; DE Short=MGP {ECO:0000256|RuleBase:RU361261}; DE Flags: Fragment; GN Name=Mgp {ECO:0000313|EMBL:AAH18338.1, ECO:0000313|MGI:MGI:96976}; GN Synonyms=Mglap {ECO:0000313|MGI:MGI:96976}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH18338.1}; RN [1] {ECO:0000313|EMBL:AAH18338.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N {ECO:0000313|EMBL:AAH18338.1}; RC TISSUE=Mammary tumor. Metallothionien-TGF alpha model. 10 month old RC virgin mouse. Taken by biopsy. {ECO:0000313|EMBL:AAH18338.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Associates with the organic matrix of bone and cartilage. CC {ECO:0000256|RuleBase:RU361261}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU361261}. CC -!- PTM: Requires vitamin K-dependent gamma-carboxylation for its function. CC {ECO:0000256|RuleBase:RU361261}. CC -!- SIMILARITY: Belongs to the osteocalcin/matrix Gla protein family. CC {ECO:0000256|ARBA:ARBA00008850, ECO:0000256|RuleBase:RU361261}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC018338; AAH18338.1; -; mRNA. DR MGI; MGI:96976; Mgp. DR ChiTaRS; Mgp; mouse. DR GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro. DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0030500; P:regulation of bone mineralization; IEA:InterPro. DR InterPro; IPR035972; GLA-like_dom_SF. DR InterPro; IPR000294; GLA_domain. DR InterPro; IPR027118; MGP. DR InterPro; IPR002384; Osteocalcin/MGP. DR PANTHER; PTHR10109; PTHR10109; 1. DR PRINTS; PR00002; GLABONE. DR SMART; SM00069; GLA; 1. DR SUPFAM; SSF57630; SSF57630; 1. DR PROSITE; PS00011; GLA_1; 1. DR PROSITE; PS50998; GLA_2; 1. PE 2: Evidence at transcript level; KW Chondrogenesis {ECO:0000256|ARBA:ARBA00023188}; KW Developmental protein {ECO:0000256|ARBA:ARBA00022473}; KW Differentiation {ECO:0000256|ARBA:ARBA00022782}; KW Gamma-carboxyglutamic acid {ECO:0000256|RuleBase:RU361261}; KW Osteogenesis {ECO:0000256|ARBA:ARBA00022855}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Secreted {ECO:0000256|RuleBase:RU361261}. FT DOMAIN 56..86 FT /note="Gla" FT /evidence="ECO:0000259|PROSITE:PS50998" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AAH18338.1" SQ SEQUENCE 93 AA; 11236 MW; 0BC6BA44A0141AE1 CRC64; ALAVATLCYE SHESMESYEI SPFINRRNAN TFMSPQQRWR AKAQKRVQER NKPAYEINRE ACDDYKLCER YAMVYGYNAA YNRYFRQRRG ARY //