ID   Q8VEK8_MOUSE            Unreviewed;        93 AA.
AC   Q8VEK8;
DT   01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2002, sequence version 1.
DT   05-OCT-2016, entry version 77.
DE   RecName: Full=Osteocalcin {ECO:0000256|RuleBase:RU361261};
DE   Flags: Fragment;
GN   Name=Mgp {ECO:0000313|EMBL:AAH18338.1, ECO:0000313|MGI:MGI:96976};
GN   Synonyms=Mglap {ECO:0000313|MGI:MGI:96976};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH18338.1};
RN   [1] {ECO:0000313|EMBL:AAH18338.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N {ECO:0000313|EMBL:AAH18338.1};
RC   TISSUE=Mammary tumor. Metallothionien-TGF alpha model. 10 month old
RC   virgin mouse. Taken by biopsy. {ECO:0000313|EMBL:AAH18338.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
RA   Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
RA   Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
RA   Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
RA   Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
RA   Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
RA   Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
RA   Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
RA   Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
RA   Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
RA   Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
RA   Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
RA   Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
RA   Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
RA   Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
RA   Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
RA   Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
RA   Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
RA   Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Binds strongly to apatite and calcium.
CC       {ECO:0000256|RuleBase:RU361261}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU361261}.
CC   -!- PTM: Gamma-carboxyglutamate residues are formed by vitamin K
CC       dependent carboxylation. These residues are essential for the
CC       binding of calcium. {ECO:0000256|RuleBase:RU361261}.
CC   -!- SIMILARITY: Belongs to the osteocalcin/matrix Gla protein family.
CC       {ECO:0000256|RuleBase:RU361261}.
CC   -!- SIMILARITY: Contains 1 Gla (gamma-carboxy-glutamate) domain.
CC       {ECO:0000256|RuleBase:RU361261}.
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DR   EMBL; BC018338; AAH18338.1; -; mRNA.
DR   UniGene; Mm.243085; -.
DR   STRING; 10090.ENSMUSP00000032342; -.
DR   PaxDb; Q8VEK8; -.
DR   MGI; MGI:96976; Mgp.
DR   eggNOG; ENOG410IZCH; Eukaryota.
DR   eggNOG; ENOG410Y2RM; LUCA.
DR   ChiTaRS; Mgp; mouse.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0030500; P:regulation of bone mineralization; IEA:InterPro.
DR   InterPro; IPR000294; GLA_domain.
DR   InterPro; IPR002384; Osteocalcin/MGP.
DR   PRINTS; PR00002; GLABONE.
DR   SMART; SM00069; GLA; 1.
DR   SUPFAM; SSF57630; SSF57630; 1.
DR   PROSITE; PS00011; GLA_1; 1.
DR   PROSITE; PS50998; GLA_2; 1.
PE   2: Evidence at transcript level;
KW   Calcium {ECO:0000256|RuleBase:RU361261};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00522304};
KW   Gamma-carboxyglutamic acid {ECO:0000256|RuleBase:RU361261};
KW   Metal-binding {ECO:0000256|RuleBase:RU361261};
KW   Secreted {ECO:0000256|RuleBase:RU361261}.
FT   DOMAIN       56     86       Gla (gamma-carboxy-glutamate).
FT                                {ECO:0000259|PROSITE:PS50998}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:AAH18338.1}.
SQ   SEQUENCE   93 AA;  11236 MW;  0BC6BA44A0141AE1 CRC64;
     ALAVATLCYE SHESMESYEI SPFINRRNAN TFMSPQQRWR AKAQKRVQER NKPAYEINRE
     ACDDYKLCER YAMVYGYNAA YNRYFRQRRG ARY
//