ID Q8VEK8_MOUSE Unreviewed; 93 AA. AC Q8VEK8; DT 01-MAR-2002, integrated into UniProtKB/TrEMBL. DT 01-MAR-2002, sequence version 1. DT 07-JAN-2015, entry version 68. DE RecName: Full=Matrix Gla protein {ECO:0000256|RuleBase:RU361261}; DE Short=MGP {ECO:0000256|RuleBase:RU361261}; DE Flags: Fragment; GN Name=Mgp {ECO:0000313|EMBL:AAH18338.1, ECO:0000313|MGI:MGI:96976}; GN Synonyms=Mglap {ECO:0000313|MGI:MGI:96976}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH18338.1}; RN [1] {ECO:0000313|EMBL:AAH18338.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N {ECO:0000313|EMBL:AAH18338.1}; RC TISSUE=Mammary tumor. Metallothionien-TGF alpha model. 10 month old RC virgin mouse. Taken by biopsy. {ECO:0000313|EMBL:AAH18338.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Associates with the organic matrix of bone and CC cartilage. {ECO:0000256|RuleBase:RU361261}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU361261}. CC -!- PTM: Requires vitamin K-dependent gamma-carboxylation for its CC function. {ECO:0000256|RuleBase:RU361261}. CC -!- SIMILARITY: Belongs to the osteocalcin/matrix Gla protein family. CC {ECO:0000256|RuleBase:RU361261}. CC -!- SIMILARITY: Contains 1 Gla (gamma-carboxy-glutamate) domain. CC {ECO:0000256|RuleBase:RU361261}. CC -!- SIMILARITY: Contains Gla (gamma-carboxy-glutamate) domain. CC {ECO:0000256|SAAS:SAAS00178117}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC018338; AAH18338.1; -; mRNA. DR UniGene; Mm.243085; -. DR PRIDE; Q8VEK8; -. DR MGI; MGI:96976; Mgp. DR ChiTaRS; Mgp; mouse. DR Genevestigator; Q8VEK8; -. DR GO; GO:0031012; C:extracellular matrix; IEA:InterPro. DR GO; GO:0005576; C:extracellular region; IEA:InterPro. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0030500; P:regulation of bone mineralization; IEA:InterPro. DR InterPro; IPR000294; GLA_domain. DR InterPro; IPR027118; MGP. DR InterPro; IPR002384; Osteocalcin/MGP. DR PANTHER; PTHR10109; PTHR10109; 1. DR Pfam; PF00594; Gla; 1. DR PRINTS; PR00002; GLABONE. DR SMART; SM00069; GLA; 1. DR SUPFAM; SSF57630; SSF57630; 1. DR PROSITE; PS00011; GLA_1; 1. DR PROSITE; PS50998; GLA_2; 1. PE 2: Evidence at transcript level; KW Disulfide bond {ECO:0000256|SAAS:SAAS00178122}; KW Gamma-carboxyglutamic acid {ECO:0000256|RuleBase:RU361261}; KW Secreted {ECO:0000256|RuleBase:RU361261}. FT NON_TER 1 1 {ECO:0000313|EMBL:AAH18338.1}. SQ SEQUENCE 93 AA; 11236 MW; 0BC6BA44A0141AE1 CRC64; ALAVATLCYE SHESMESYEI SPFINRRNAN TFMSPQQRWR AKAQKRVQER NKPAYEINRE ACDDYKLCER YAMVYGYNAA YNRYFRQRRG ARY //