ID Q8VBX9_MOUSE Unreviewed; 221 AA. AC Q8VBX9; DT 01-MAR-2002, integrated into UniProtKB/TrEMBL. DT 01-MAR-2002, sequence version 1. DT 03-MAR-2009, entry version 55. DE SubName: Full=Pax6 paired-less isoform; DE SubName: Full=Paired box gene 6, isoform CRA_c; GN Name=Pax6; ORFNames=mCG_22492; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6; TISSUE=Eye, and Brain; RX MEDLINE=22306463; PubMed=12419357; DOI=10.1016/S0003-2697(02)00244-0; RA Gorlov I.P., Saunders G.F.; RT "A method for isolating alternatively spliced isoforms: isolation of RT murine Pax6 isoforms."; RL Anal. Biochem. 308:401-404(2002). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed; RX MEDLINE=22036378; PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and RT the human genome."; RL Science 296:1661-1671(2002). RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6; TISSUE=Brain; RX MEDLINE=22371022; PubMed=12388550; DOI=10.1074/jbc.M206478200; RA Mishra R., Gorlov I.P., Chao L.Y., Singh S., Saunders G.F.; RT "PAX6, paired domain influences sequence recognition by the RT homeodomain."; RL J. Biol. Chem. 277:49488-49494(2002). CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY064175; AAL40860.1; -; mRNA. DR EMBL; AF457141; AAL67742.1; -; mRNA. DR EMBL; CH466519; EDL27747.1; -; Genomic_DNA. DR IPI; IPI00894586; -. DR UniGene; Mm.33870; -. DR UniGene; Mm.3608; -. DR HSSP; P06601; 1FJL. DR SMR; Q8VBX9; 10-77. DR Ensembl; ENSMUSG00000027168; Mus musculus. DR MGI; MGI:97490; Pax6. DR HOVERGEN; Q8VBX9; -. DR ArrayExpress; Q8VBX9; -. DR Bgee; Q8VBX9; -. DR GO; GO:0005667; C:transcription factor complex; TAS:MGI. DR GO; GO:0005515; F:protein binding; IPI:MGI. DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. DR GO; GO:0003700; F:transcription factor activity; IDA:MGI. DR GO; GO:0003700; F:transcription factor activity; TAS:MGI. DR GO; GO:0007411; P:axon guidance; IMP:MGI. DR GO; GO:0043010; P:camera-type eye development; IGI:MGI. DR GO; GO:0043010; P:camera-type eye development; IMP:MGI. DR GO; GO:0001709; P:cell fate determination; IMP:MGI. DR GO; GO:0021902; P:commitment of a neuronal cell to a specific...; IMP:MGI. DR GO; GO:0009950; P:dorsal/ventral axis specification; IMP:MGI. DR GO; GO:0042462; P:eye photoreceptor cell development; IMP:MGI. DR GO; GO:0021797; P:forebrain anterior/posterior pattern formation; IMP:MGI. DR GO; GO:0021798; P:forebrain dorsal/ventral pattern formation; IMP:MGI. DR GO; GO:0021905; P:forebrain-midbrain boundary formation; IMP:MGI. DR GO; GO:0030216; P:keratinocyte differentiation; IMP:MGI. DR GO; GO:0050680; P:negative regulation of epithelial cell prol...; IMP:MGI. DR GO; GO:0045665; P:negative regulation of neuron differentiation; IGI:MGI. DR GO; GO:0001764; P:neuron migration; IMP:MGI. DR GO; GO:0021543; P:pallium development; IMP:MGI. DR GO; GO:0021983; P:pituitary gland development; IMP:MGI. DR GO; GO:0030858; P:positive regulation of epithelial cell diff...; IMP:MGI. DR GO; GO:0002052; P:positive regulation of neuroblast prolifera...; IMP:MGI. DR GO; GO:0045944; P:positive regulation of transcription from R...; IDA:MGI. DR GO; GO:0033365; P:protein localization in organelle; IMP:MGI. DR GO; GO:0030334; P:regulation of cell migration; IMP:MGI. DR GO; GO:0007435; P:salivary gland morphogenesis; IMP:MGI. DR InterPro; IPR001356; Homeobox. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR012287; Homeodomain-rel. DR Gene3D; G3DSA:1.10.10.60; Homeodomain-rel; 1. DR Pfam; PF00046; Homeobox; 1. DR ProDom; PD000010; Homeobox; 1. DR SMART; SM00389; HOX; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. PE 2: Evidence at transcript level; KW DNA-binding; Homeobox; Nucleus. SQ SEQUENCE 221 AA; 24949 MW; 2B5AECC2464BBCE3 CRC64; MRLQLKRKLQ RNRTSFTQEQ IEALEKEFER THYPDVFARE RLAAKIDLPE ARIQVWFSNR RAKWRREEKL RNQRRQASNT PSHIPISSSF STSVYQPIPQ PTTPVSSFTS GSMLGRTDTA LTNTYSALPP MPSFTMANNL PMQPPVPSQT SSYSCMLPTS PSVNGRSYDT YTPPHMQTHM NSQPMGTSGT TSTGLISPGV SVPVQVPGSE PDMSQYWPRL Q //