ID Q8VBX9_MOUSE Unreviewed; 221 AA. AC Q8VBX9; DT 01-MAR-2002, integrated into UniProtKB/TrEMBL. DT 01-MAR-2002, sequence version 1. DT 12-OCT-2022, entry version 154. DE SubName: Full=Pax6 paired-less isoform {ECO:0000313|EMBL:AAL67742.1}; GN Name=Pax6 {ECO:0000313|MGI:MGI:97490}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAL67742.1}; RN [1] {ECO:0000313|EMBL:AAL67742.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAL67742.1}; RC TISSUE=Brain {ECO:0000313|EMBL:AAL40860.1}, and Eye RC {ECO:0000313|EMBL:AAL67742.1}; RX PubMed=12419357; DOI=10.1016/S0003-2697(02)00244-0; RA Gorlov I.P., Saunders G.F.; RT "A method for isolating alternatively spliced isoforms: isolation of murine RT Pax6 isoforms."; RL Anal. Biochem. 308:401-404(2002). RN [2] {ECO:0000313|EMBL:AAL40860.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAL40860.1}; RC TISSUE=Brain {ECO:0000313|EMBL:AAL40860.1}; RX PubMed=12388550; DOI=10.1074/jbc.M206478200; RA Mishra R., Gorlov I.P., Chao L.Y., Singh S., Saunders G.F.; RT "PAX6, paired domain influences sequence recognition by the homeodomain."; RL J. Biol. Chem. 277:49488-49494(2002). CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108, CC ECO:0000256|RuleBase:RU000682}. CC -!- SIMILARITY: Belongs to the paired homeobox family. CC {ECO:0000256|ARBA:ARBA00005733}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY064175; AAL40860.1; -; mRNA. DR EMBL; AF457141; AAL67742.1; -; mRNA. DR RefSeq; NP_001231129.1; NM_001244200.2. DR RefSeq; NP_001297073.1; NM_001310144.1. DR SMR; Q8VBX9; -. DR MaxQB; Q8VBX9; -. DR DNASU; 18508; -. DR GeneID; 18508; -. DR CTD; 5080; -. DR MGI; MGI:97490; Pax6. DR BioGRID-ORCS; 18508; 2 hits in 72 CRISPR screens. DR ChiTaRS; Pax6; mouse. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro. DR CDD; cd00086; homeodomain; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR043565; PAX_fam. DR PANTHER; PTHR45636; PTHR45636; 1. DR Pfam; PF00046; Homeodomain; 1. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF46689; SSF46689; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. PE 2: Evidence at transcript level; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE- KW ProRule:PRU00108}; KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE- KW ProRule:PRU00108}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE- KW ProRule:PRU00108}. FT DOMAIN 7..67 FT /note="Homeobox" FT /evidence="ECO:0000259|PROSITE:PS50071" FT DNA_BIND 9..68 FT /note="Homeobox" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108" FT REGION 66..111 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 75..111 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 221 AA; 24949 MW; 2B5AECC2464BBCE3 CRC64; MRLQLKRKLQ RNRTSFTQEQ IEALEKEFER THYPDVFARE RLAAKIDLPE ARIQVWFSNR RAKWRREEKL RNQRRQASNT PSHIPISSSF STSVYQPIPQ PTTPVSSFTS GSMLGRTDTA LTNTYSALPP MPSFTMANNL PMQPPVPSQT SSYSCMLPTS PSVNGRSYDT YTPPHMQTHM NSQPMGTSGT TSTGLISPGV SVPVQVPGSE PDMSQYWPRL Q //