ID Q8VBX9_MOUSE Unreviewed; 221 AA. AC Q8VBX9; DT 01-MAR-2002, integrated into UniProtKB/TrEMBL. DT 01-MAR-2002, sequence version 1. DT 22-NOV-2017, entry version 132. DE SubName: Full=Paired box gene 6, isoform CRA_c {ECO:0000313|EMBL:EDL27747.1}; DE SubName: Full=Pax6 paired-less isoform {ECO:0000313|EMBL:AAL67742.1}; GN Name=Pax6 {ECO:0000313|EMBL:EDL27747.1, ECO:0000313|MGI:MGI:97490}; GN ORFNames=mCG_22492 {ECO:0000313|EMBL:EDL27747.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] {ECO:0000313|EMBL:AAL67742.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAL67742.1}; RC TISSUE=Brain {ECO:0000313|EMBL:AAL40860.1}, and Eye RC {ECO:0000313|EMBL:AAL67742.1}; RX PubMed=12419357; DOI=10.1016/S0003-2697(02)00244-0; RA Gorlov I.P., Saunders G.F.; RT "A method for isolating alternatively spliced isoforms: isolation of RT murine Pax6 isoforms."; RL Anal. Biochem. 308:401-404(2002). RN [2] {ECO:0000313|EMBL:AAL40860.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAL40860.1}; RC TISSUE=Brain {ECO:0000313|EMBL:AAL40860.1}; RX PubMed=12388550; DOI=10.1074/jbc.M206478200; RA Mishra R., Gorlov I.P., Chao L.Y., Singh S., Saunders G.F.; RT "PAX6, paired domain influences sequence recognition by the RT homeodomain."; RL J. Biol. Chem. 277:49488-49494(2002). RN [3] {ECO:0000313|EMBL:EDL27747.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL27747.1}; RX PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and RT the human genome."; RL Science 296:1661-1671(2002). RN [4] {ECO:0000313|EMBL:EDL27747.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL27747.1}; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE- CC ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY064175; AAL40860.1; -; mRNA. DR EMBL; AF457141; AAL67742.1; -; mRNA. DR EMBL; CH466519; EDL27747.1; -; Genomic_DNA. DR RefSeq; NP_001231129.1; NM_001244200.2. DR RefSeq; NP_001297073.1; NM_001310144.1. DR UniGene; Mm.3608; -. DR UniGene; Mm.487124; -. DR MaxQB; Q8VBX9; -. DR GeneID; 18508; -. DR CTD; 5080; -. DR MGI; MGI:97490; Pax6. DR eggNOG; KOG0849; Eukaryota. DR eggNOG; ENOG410XS01; LUCA. DR HOVERGEN; HBG009115; -. DR ChiTaRS; Pax6; mouse. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro. DR CDD; cd00086; homeodomain; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR Pfam; PF00046; Homeobox; 1. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF46689; SSF46689; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. PE 2: Evidence at transcript level; KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108, KW ECO:0000256|RuleBase:RU000682}; KW Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108, KW ECO:0000256|RuleBase:RU000682}; KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108, KW ECO:0000256|RuleBase:RU000682}. FT DOMAIN 7 67 Homeobox. {ECO:0000259|PROSITE:PS50071}. FT DNA_BIND 9 68 Homeobox. {ECO:0000256|PROSITE-ProRule: FT PRU00108}. SQ SEQUENCE 221 AA; 24949 MW; 2B5AECC2464BBCE3 CRC64; MRLQLKRKLQ RNRTSFTQEQ IEALEKEFER THYPDVFARE RLAAKIDLPE ARIQVWFSNR RAKWRREEKL RNQRRQASNT PSHIPISSSF STSVYQPIPQ PTTPVSSFTS GSMLGRTDTA LTNTYSALPP MPSFTMANNL PMQPPVPSQT SSYSCMLPTS PSVNGRSYDT YTPPHMQTHM NSQPMGTSGT TSTGLISPGV SVPVQVPGSE PDMSQYWPRL Q //