ID Q8VBX9_MOUSE Unreviewed; 221 AA. AC Q8VBX9; DT 01-MAR-2002, integrated into UniProtKB/TrEMBL. DT 01-MAR-2002, sequence version 1. DT 11-NOV-2015, entry version 117. DE SubName: Full=Paired box gene 6, isoform CRA_c {ECO:0000313|EMBL:EDL27747.1}; DE SubName: Full=Pax6 paired-less isoform {ECO:0000313|EMBL:AAL67742.1}; GN Name=Pax6 {ECO:0000313|EMBL:EDL27747.1, ECO:0000313|MGI:MGI:97490}; GN ORFNames=mCG_22492 {ECO:0000313|EMBL:EDL27747.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] {ECO:0000313|EMBL:AAL67742.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAL67742.1}; RC TISSUE=Brain {ECO:0000313|EMBL:AAL40860.1}, and Eye RC {ECO:0000313|EMBL:AAL67742.1}; RX PubMed=12419357; DOI=10.1016/S0003-2697(02)00244-0; RA Gorlov I.P., Saunders G.F.; RT "A method for isolating alternatively spliced isoforms: isolation of RT murine Pax6 isoforms."; RL Anal. Biochem. 308:401-404(2002). RN [2] {ECO:0000313|EMBL:AAL40860.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAL40860.1}; RC TISSUE=Brain {ECO:0000313|EMBL:AAL40860.1}; RX PubMed=12388550; DOI=10.1074/jbc.M206478200; RA Mishra R., Gorlov I.P., Chao L.Y., Singh S., Saunders G.F.; RT "PAX6, paired domain influences sequence recognition by the RT homeodomain."; RL J. Biol. Chem. 277:49488-49494(2002). RN [3] {ECO:0000313|EMBL:EDL27747.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL27747.1}; RX PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and RT the human genome."; RL Science 296:1661-1671(2002). RN [4] {ECO:0000313|EMBL:EDL27747.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL27747.1}; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000682}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY064175; AAL40860.1; -; mRNA. DR EMBL; AF457141; AAL67742.1; -; mRNA. DR EMBL; CH466519; EDL27747.1; -; Genomic_DNA. DR RefSeq; NP_001231129.1; NM_001244200.2. DR RefSeq; NP_001297073.1; NM_001310144.1. DR UniGene; Mm.3608; -. DR UniGene; Mm.487124; -. DR STRING; 10090.ENSMUSP00000087870; -. DR GeneID; 18508; -. DR CTD; 5080; -. DR MGI; MGI:97490; Pax6. DR eggNOG; KOG0849; Eukaryota. DR eggNOG; ENOG410XS01; LUCA. DR HOVERGEN; HBG009115; -. DR ChiTaRS; Pax6; mouse. DR NextBio; 294236; -. DR GO; GO:0005737; C:cytoplasm; ISO:MGI. DR GO; GO:0005622; C:intracellular; IDA:MGI. DR GO; GO:0000790; C:nuclear chromatin; ISO:MGI. DR GO; GO:0005654; C:nucleoplasm; ISO:MGI. DR GO; GO:0005634; C:nucleus; IDA:MGI. DR GO; GO:0005667; C:transcription factor complex; TAS:MGI. DR GO; GO:0003682; F:chromatin binding; IDA:MGI. DR GO; GO:0003677; F:DNA binding; IDA:MGI. DR GO; GO:0070412; F:R-SMAD binding; ISO:MGI. DR GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; ISO:MGI. DR GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISO:MGI. DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI. DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:MGI. DR GO; GO:0044212; F:transcription regulatory region DNA binding; IDA:MGI. DR GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding; IDA:MGI. DR GO; GO:0001227; F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding; IDA:MGI. DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI. DR GO; GO:0048708; P:astrocyte differentiation; IMP:MGI. DR GO; GO:0007411; P:axon guidance; IMP:MGI. DR GO; GO:0007409; P:axonogenesis; IMP:MGI. DR GO; GO:0001568; P:blood vessel development; ISO:MGI. DR GO; GO:0007420; P:brain development; IMP:MGI. DR GO; GO:0043010; P:camera-type eye development; IMP:MGI. DR GO; GO:0030154; P:cell differentiation; IMP:MGI. DR GO; GO:0045165; P:cell fate commitment; IMP:MGI. DR GO; GO:0001709; P:cell fate determination; IMP:MGI. DR GO; GO:0021796; P:cerebral cortex regionalization; IMP:MGI. DR GO; GO:0021902; P:commitment of neuronal cell to specific neuron type in forebrain; IMP:MGI. DR GO; GO:0061303; P:cornea development in camera-type eye; ISO:MGI. DR GO; GO:0009950; P:dorsal/ventral axis specification; IMP:MGI. DR GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:MGI. DR GO; GO:0048596; P:embryonic camera-type eye morphogenesis; IGI:MGI. DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IMP:MGI. DR GO; GO:0042462; P:eye photoreceptor cell development; IMP:MGI. DR GO; GO:0021797; P:forebrain anterior/posterior pattern specification; IMP:MGI. DR GO; GO:0030900; P:forebrain development; IMP:MGI. DR GO; GO:0021798; P:forebrain dorsal/ventral pattern formation; IMP:MGI. DR GO; GO:0021905; P:forebrain-midbrain boundary formation; IMP:MGI. DR GO; GO:0042593; P:glucose homeostasis; ISO:MGI. DR GO; GO:0061072; P:iris morphogenesis; ISO:MGI. DR GO; GO:0030216; P:keratinocyte differentiation; IMP:MGI. DR GO; GO:0032808; P:lacrimal gland development; IMP:MGI. DR GO; GO:0002088; P:lens development in camera-type eye; IMP:MGI. DR GO; GO:0008285; P:negative regulation of cell proliferation; IMP:MGI. DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:MGI. DR GO; GO:2000178; P:negative regulation of neural precursor cell proliferation; IMP:MGI. DR GO; GO:0045665; P:negative regulation of neuron differentiation; IGI:MGI. DR GO; GO:0001933; P:negative regulation of protein phosphorylation; IMP:MGI. DR GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:GOC. DR GO; GO:0001764; P:neuron migration; IMP:MGI. DR GO; GO:0021778; P:oligodendrocyte cell fate specification; IMP:MGI. DR GO; GO:0021543; P:pallium development; IMP:MGI. DR GO; GO:0003322; P:pancreatic A cell development; ISO:MGI. DR GO; GO:0021983; P:pituitary gland development; IMP:MGI. DR GO; GO:0030858; P:positive regulation of epithelial cell differentiation; IMP:MGI. DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI. DR GO; GO:0002052; P:positive regulation of neuroblast proliferation; IMP:MGI. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI. DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI. DR GO; GO:0033365; P:protein localization to organelle; IMP:MGI. DR GO; GO:0009786; P:regulation of asymmetric cell division; IMP:MGI. DR GO; GO:0030334; P:regulation of cell migration; IMP:MGI. DR GO; GO:0010468; P:regulation of gene expression; IMP:MGI. DR GO; GO:0050767; P:regulation of neurogenesis; IMP:MGI. DR GO; GO:0048505; P:regulation of timing of cell differentiation; IMP:MGI. DR GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:MGI. DR GO; GO:0021918; P:regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment; IMP:MGI. DR GO; GO:0021912; P:regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification; IMP:MGI. DR GO; GO:0021913; P:regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification; IMP:MGI. DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:MGI. DR GO; GO:0060041; P:retina development in camera-type eye; IGI:MGI. DR GO; GO:0007435; P:salivary gland morphogenesis; IMP:MGI. DR GO; GO:0023019; P:signal transduction involved in regulation of gene expression; IDA:MGI. DR GO; GO:0007224; P:smoothened signaling pathway; IDA:MGI. DR GO; GO:0021978; P:telencephalon regionalization; IMP:MGI. DR GO; GO:0006366; P:transcription from RNA polymerase II promoter; ISO:MGI. DR GO; GO:0003309; P:type B pancreatic cell differentiation; IMP:MGI. DR Gene3D; 1.10.10.60; -; 1. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR009057; Homeodomain-like. DR Pfam; PF00046; Homeobox; 1. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF46689; SSF46689; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW DNA-binding {ECO:0000256|RuleBase:RU000682}; KW Homeobox {ECO:0000256|RuleBase:RU000682}; KW Nucleus {ECO:0000256|RuleBase:RU000682}. FT COILED 7 27 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 221 AA; 24949 MW; 2B5AECC2464BBCE3 CRC64; MRLQLKRKLQ RNRTSFTQEQ IEALEKEFER THYPDVFARE RLAAKIDLPE ARIQVWFSNR RAKWRREEKL RNQRRQASNT PSHIPISSSF STSVYQPIPQ PTTPVSSFTS GSMLGRTDTA LTNTYSALPP MPSFTMANNL PMQPPVPSQT SSYSCMLPTS PSVNGRSYDT YTPPHMQTHM NSQPMGTSGT TSTGLISPGV SVPVQVPGSE PDMSQYWPRL Q //