ID Q8VBX9_MOUSE Unreviewed; 221 AA. AC Q8VBX9; DT 01-MAR-2002, integrated into UniProtKB/TrEMBL. DT 01-MAR-2002, sequence version 1. DT 04-MAR-2015, entry version 110. DE SubName: Full=Paired box gene 6, isoform CRA_c {ECO:0000313|EMBL:EDL27747.1}; DE SubName: Full=Pax6 paired-less isoform {ECO:0000313|EMBL:AAL67742.1}; GN Name=Pax6 {ECO:0000313|EMBL:EDL27747.1, ECO:0000313|MGI:MGI:97490}; GN ORFNames=mCG_22492 {ECO:0000313|EMBL:EDL27747.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] {ECO:0000313|EMBL:AAL67742.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAL67742.1}; RC TISSUE=Brain {ECO:0000313|EMBL:AAL40860.1}, and Eye RC {ECO:0000313|EMBL:AAL67742.1}; RX PubMed=12419357; DOI=10.1016/S0003-2697(02)00244-0; RA Gorlov I.P., Saunders G.F.; RT "A method for isolating alternatively spliced isoforms: isolation of RT murine Pax6 isoforms."; RL Anal. Biochem. 308:401-404(2002). RN [2] {ECO:0000313|EMBL:AAL40860.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAL40860.1}; RC TISSUE=Brain {ECO:0000313|EMBL:AAL40860.1}; RX PubMed=12388550; DOI=10.1074/jbc.M206478200; RA Mishra R., Gorlov I.P., Chao L.Y., Singh S., Saunders G.F.; RT "PAX6, paired domain influences sequence recognition by the RT homeodomain."; RL J. Biol. Chem. 277:49488-49494(2002). RN [3] {ECO:0000313|EMBL:EDL27747.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL27747.1}; RX PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and RT the human genome."; RL Science 296:1661-1671(2002). RN [4] {ECO:0000313|EMBL:EDL27747.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL27747.1}; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000682}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY064175; AAL40860.1; -; mRNA. DR EMBL; AF457141; AAL67742.1; -; mRNA. DR EMBL; CH466519; EDL27747.1; -; Genomic_DNA. DR RefSeq; NP_001231129.1; NM_001244200.1. DR UniGene; Mm.33870; -. DR UniGene; Mm.3608; -. DR UniGene; Mm.487124; -. DR GeneID; 18508; -. DR KEGG; mmu:18508; -. DR CTD; 5080; -. DR MGI; MGI:97490; Pax6. DR HOVERGEN; HBG009115; -. DR KO; K08031; -. DR ChiTaRS; Pax6; mouse. DR NextBio; 294236; -. DR Genevestigator; Q8VBX9; -. DR GO; GO:0005737; C:cytoplasm; ISO:MGI. DR GO; GO:0005622; C:intracellular; IDA:MGI. DR GO; GO:0000790; C:nuclear chromatin; ISO:MGI. DR GO; GO:0005654; C:nucleoplasm; ISO:MGI. DR GO; GO:0005634; C:nucleus; IDA:MGI. DR GO; GO:0005667; C:transcription factor complex; TAS:MGI. DR GO; GO:0003680; F:AT DNA binding; IEA:Ensembl. DR GO; GO:0003682; F:chromatin binding; IDA:MGI. DR GO; GO:0003677; F:DNA binding; IDA:MGI. DR GO; GO:0003690; F:double-stranded DNA binding; IEA:Ensembl. DR GO; GO:0070412; F:R-SMAD binding; ISO:MGI. DR GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; ISO:MGI. DR GO; GO:0001227; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IDA:MGI. DR GO; GO:0001228; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:MGI. DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI. DR GO; GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; ISO:MGI. DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI. DR GO; GO:0044212; F:transcription regulatory region DNA binding; IDA:MGI. DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI. DR GO; GO:0048708; P:astrocyte differentiation; IMP:MGI. DR GO; GO:0007411; P:axon guidance; IMP:MGI. DR GO; GO:0007409; P:axonogenesis; IMP:MGI. DR GO; GO:0001568; P:blood vessel development; ISO:MGI. DR GO; GO:0007420; P:brain development; IMP:MGI. DR GO; GO:0043010; P:camera-type eye development; IMP:MGI. DR GO; GO:0030154; P:cell differentiation; IMP:MGI. DR GO; GO:0045165; P:cell fate commitment; IMP:MGI. DR GO; GO:0001709; P:cell fate determination; IMP:MGI. DR GO; GO:0035690; P:cellular response to drug; IEA:Ensembl. DR GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl. DR GO; GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl. DR GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl. DR GO; GO:0071380; P:cellular response to prostaglandin E stimulus; IEA:Ensembl. DR GO; GO:0021549; P:cerebellum development; IEA:Ensembl. DR GO; GO:0021796; P:cerebral cortex regionalization; IMP:MGI. DR GO; GO:0021902; P:commitment of neuronal cell to specific neuron type in forebrain; IMP:MGI. DR GO; GO:0061303; P:cornea development in camera-type eye; ISO:MGI. DR GO; GO:0009950; P:dorsal/ventral axis specification; IMP:MGI. DR GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:MGI. DR GO; GO:0048596; P:embryonic camera-type eye morphogenesis; IGI:MGI. DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IMP:MGI. DR GO; GO:0042462; P:eye photoreceptor cell development; IMP:MGI. DR GO; GO:0021797; P:forebrain anterior/posterior pattern specification; IMP:MGI. DR GO; GO:0030900; P:forebrain development; IMP:MGI. DR GO; GO:0021798; P:forebrain dorsal/ventral pattern formation; IMP:MGI. DR GO; GO:0021905; P:forebrain-midbrain boundary formation; IMP:MGI. DR GO; GO:0042593; P:glucose homeostasis; ISO:MGI. DR GO; GO:1901142; P:insulin metabolic process; IEA:Ensembl. DR GO; GO:0022027; P:interkinetic nuclear migration; IEA:Ensembl. DR GO; GO:0061072; P:iris morphogenesis; ISO:MGI. DR GO; GO:0030216; P:keratinocyte differentiation; IMP:MGI. DR GO; GO:0032808; P:lacrimal gland development; IMP:MGI. DR GO; GO:0002088; P:lens development in camera-type eye; IMP:MGI. DR GO; GO:0008285; P:negative regulation of cell proliferation; IMP:MGI. DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:MGI. DR GO; GO:2000178; P:negative regulation of neural precursor cell proliferation; IMP:MGI. DR GO; GO:0045665; P:negative regulation of neuron differentiation; IGI:MGI. DR GO; GO:0001933; P:negative regulation of protein phosphorylation; IMP:MGI. DR GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:GOC. DR GO; GO:0001755; P:neural crest cell migration; IEA:Ensembl. DR GO; GO:0001764; P:neuron migration; IMP:MGI. DR GO; GO:0021772; P:olfactory bulb development; IEA:Ensembl. DR GO; GO:0021778; P:oligodendrocyte cell fate specification; IMP:MGI. DR GO; GO:0021543; P:pallium development; IMP:MGI. DR GO; GO:0003322; P:pancreatic A cell development; ISO:MGI. DR GO; GO:0021983; P:pituitary gland development; IMP:MGI. DR GO; GO:0042660; P:positive regulation of cell fate specification; IEA:Ensembl. DR GO; GO:0030858; P:positive regulation of epithelial cell differentiation; IMP:MGI. DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI. DR GO; GO:0070094; P:positive regulation of glucagon secretion; IEA:Ensembl. DR GO; GO:0002052; P:positive regulation of neuroblast proliferation; IMP:MGI. DR GO; GO:2001224; P:positive regulation of neuron migration; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI. DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI. DR GO; GO:0033365; P:protein localization to organelle; IMP:MGI. DR GO; GO:0009786; P:regulation of asymmetric cell division; IMP:MGI. DR GO; GO:0030334; P:regulation of cell migration; IMP:MGI. DR GO; GO:0010468; P:regulation of gene expression; IMP:MGI. DR GO; GO:0050767; P:regulation of neurogenesis; IMP:MGI. DR GO; GO:0010975; P:regulation of neuron projection development; IEA:Ensembl. DR GO; GO:0048505; P:regulation of timing of cell differentiation; IMP:MGI. DR GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:MGI. DR GO; GO:0021918; P:regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment; IMP:MGI. DR GO; GO:0021912; P:regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification; IMP:MGI. DR GO; GO:0021913; P:regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification; IMP:MGI. DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:MGI. DR GO; GO:0045471; P:response to ethanol; IEA:Ensembl. DR GO; GO:0009611; P:response to wounding; IEA:Ensembl. DR GO; GO:0060041; P:retina development in camera-type eye; IGI:MGI. DR GO; GO:0021593; P:rhombomere morphogenesis; IEA:Ensembl. DR GO; GO:0007435; P:salivary gland morphogenesis; IMP:MGI. DR GO; GO:0023019; P:signal transduction involved in regulation of gene expression; IDA:MGI. DR GO; GO:0007224; P:smoothened signaling pathway; IDA:MGI. DR GO; GO:0021978; P:telencephalon regionalization; IMP:MGI. DR GO; GO:0006366; P:transcription from RNA polymerase II promoter; ISO:MGI. DR GO; GO:0003309; P:type B pancreatic cell differentiation; IMP:MGI. DR Gene3D; 1.10.10.60; -; 1. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR009057; Homeodomain-like. DR Pfam; PF00046; Homeobox; 1. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF46689; SSF46689; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. PE 2: Evidence at transcript level; KW DNA-binding {ECO:0000256|RuleBase:RU000682}; KW Homeobox {ECO:0000256|RuleBase:RU000682}; KW Nucleus {ECO:0000256|RuleBase:RU000682}. SQ SEQUENCE 221 AA; 24949 MW; 2B5AECC2464BBCE3 CRC64; MRLQLKRKLQ RNRTSFTQEQ IEALEKEFER THYPDVFARE RLAAKIDLPE ARIQVWFSNR RAKWRREEKL RNQRRQASNT PSHIPISSSF STSVYQPIPQ PTTPVSSFTS GSMLGRTDTA LTNTYSALPP MPSFTMANNL PMQPPVPSQT SSYSCMLPTS PSVNGRSYDT YTPPHMQTHM NSQPMGTSGT TSTGLISPGV SVPVQVPGSE PDMSQYWPRL Q //