ID Q8UUX5_CHICK Unreviewed; 839 AA. AC Q8UUX5; DT 01-MAR-2002, integrated into UniProtKB/TrEMBL. DT 01-MAR-2002, sequence version 1. DT 09-DEC-2015, entry version 101. DE SubName: Full=GDP/GTP exchange factor VAV2 {ECO:0000313|EMBL:AAL06250.1}; GN Name=VAV2 {ECO:0000313|EMBL:AAL06250.1}; OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; OC Phasianidae; Phasianinae; Gallus. OX NCBI_TaxID=9031 {ECO:0000313|EMBL:AAL06250.1}; RN [1] {ECO:0000313|EMBL:AAL06250.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11805146; DOI=10.1084/jem.20011571; RA Inabe K., Ishiai M., Scharenberg A.M., Freshney N., Downward J., RA Kurosaki T.; RT "Vav3 modulates B cell receptor responses by regulating RT phosphoinositide 3-kinase activation."; RL J. Exp. Med. 195:189-200(2002). CC -!- SIMILARITY: Contains 1 PH domain. {ECO:0000256|RuleBase:RU003350}. CC -!- SIMILARITY: Contains DH (DBL-homology) domain. CC {ECO:0000256|SAAS:SAAS00412720}. CC -!- SIMILARITY: Contains SH2 domain. {ECO:0000256|SAAS:SAAS00407508}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY046916; AAL06250.1; -; mRNA. DR RefSeq; NP_989473.1; NM_204142.1. DR UniGene; Gga.4341; -. DR ProteinModelPortal; Q8UUX5; -. DR SMR; Q8UUX5; 1-131, 654-757, 781-839. DR STRING; 9031.ENSGALP00000004246; -. DR PaxDb; Q8UUX5; -. DR GeneID; 373938; -. DR KEGG; gga:373938; -. DR CTD; 7410; -. DR eggNOG; ENOG410XPH6; LUCA. DR eggNOG; KOG2996; Eukaryota. DR HOGENOM; HOG000234364; -. DR HOVERGEN; HBG018066; -. DR KO; K05730; -. DR PhylomeDB; Q8UUX5; -. DR NextBio; 20813470; -. DR GO; GO:0005622; C:intracellular; IEA:GOC. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. DR Gene3D; 1.10.418.10; -; 1. DR Gene3D; 1.20.900.10; -; 1. DR Gene3D; 2.30.29.30; -; 1. DR Gene3D; 3.30.505.10; -; 1. DR InterPro; IPR022613; CAMSAP_CH. DR InterPro; IPR001715; CH-domain. DR InterPro; IPR000219; DH-domain. DR InterPro; IPR001331; GDS_CDC24_CS. DR InterPro; IPR002219; PE/DAG-bd. DR InterPro; IPR011993; PH/PTB_dom. DR InterPro; IPR001849; PH_domain. DR InterPro; IPR000980; SH2. DR InterPro; IPR011511; SH3_2. DR InterPro; IPR001452; SH3_domain. DR InterPro; IPR028530; Vav. DR PANTHER; PTHR22826:SF95; PTHR22826:SF95; 1. DR Pfam; PF00130; C1_1; 1. DR Pfam; PF11971; CAMSAP_CH; 1. DR Pfam; PF00169; PH; 1. DR Pfam; PF00621; RhoGEF; 1. DR Pfam; PF00017; SH2; 1. DR Pfam; PF07653; SH3_2; 2. DR PRINTS; PR00401; SH2DOMAIN. DR PRINTS; PR00452; SH3DOMAIN. DR SMART; SM00109; C1; 1. DR SMART; SM00033; CH; 1. DR SMART; SM00233; PH; 1. DR SMART; SM00325; RhoGEF; 1. DR SMART; SM00252; SH2; 1. DR SMART; SM00326; SH3; 2. DR SUPFAM; SSF47576; SSF47576; 1. DR SUPFAM; SSF48065; SSF48065; 1. DR SUPFAM; SSF50044; SSF50044; 2. DR SUPFAM; SSF55550; SSF55550; 2. DR PROSITE; PS50021; CH; 1. DR PROSITE; PS00741; DH_1; 1. DR PROSITE; PS50010; DH_2; 1. DR PROSITE; PS50003; PH_DOMAIN; 1. DR PROSITE; PS50001; SH2; 1. DR PROSITE; PS50002; SH3; 2. DR PROSITE; PS00479; ZF_DAG_PE_1; 1. DR PROSITE; PS50081; ZF_DAG_PE_2; 1. PE 2: Evidence at transcript level; KW Metal-binding {ECO:0000256|SAAS:SAAS00253054}; KW SH2 domain {ECO:0000256|SAAS:SAAS00264727}; KW SH3 domain {ECO:0000256|SAAS:SAAS00333264}; KW Zinc {ECO:0000256|SAAS:SAAS00253075}. FT DOMAIN 1 119 Actin-binding. {ECO:0000259|PROSITE: FT PS50021}. FT DOMAIN 193 371 DH (DBL-homology). {ECO:0000259|PROSITE: FT PS50010}. FT DOMAIN 400 502 PH. {ECO:0000259|PROSITE:PS50003}. FT DOMAIN 513 562 Phorbol-ester/DAG-type. FT {ECO:0000259|PROSITE:PS50081}. FT DOMAIN 576 642 SH3. {ECO:0000259|PROSITE:PS50002}. FT DOMAIN 663 757 SH2. {ECO:0000259|PROSITE:PS50001}. FT DOMAIN 777 838 SH3. {ECO:0000259|PROSITE:PS50002}. SQ SEQUENCE 839 AA; 97501 MW; 6C1322ABAC23A530 CRC64; MEEWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL SPGSIDLKDI NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SDLFDPFDLF DVRDFGKVIS AVSRLSFHSI AQTKGIRPFP SEETTENDDD VYRSLEELAD EHDLGEDIYD CVPCEDEGDD IYEDIIRVEV QQPMKMGMTE DDKRNCCLLE IQETEAKYYK TLEDIEKNYM NPLKLVLTPQ DMEAIFINLE DLIKVHFNFL RAIDVSMMSG GSSLAKVFLE FKERLLIYGK YCSHMEYAQN TLNHLIANRD DVRQKVEECT LKVQDGKFKL QDLLVVPMQR VLKHYLLLKE LLSHSSDRPE KQQLKEALEA MQDLAMYINE VKRDKETLKK ISEFQSSIEN LQVKLEEFGR PKIDGELKVR SIVNHTKQDR YLFLFDKVVI VCKRKGYNYE LKEIIELLFH KMTDDPMNNK DIKKWSYGFY LIHLQGKQGF QFFCKTEEMK RKWMEQFEMA MSNIKPEKAN ANHHSFQMYT FEKTTNCKAC KMFLRGTFYQ GYLCPKCGAG AHKECLEIIP PCKMGSSADQ DLLSAGPGPK MVAVQNYHGN PAPPGKPVLT FQIGDVIELL RGDPDSPWWE GRLLQTKKSG YFPSSSVKPC PVDARPPNSR PPSREIDYTV YPWFAGNMER QQTDNLLKTH VSGTYLIRER PAEAERFAIS IKFNEEVKHI KVVEKDNWIH ITEAKKFESL LELVEYYQNH SLKESFKQLD TTLKYPYKSR ERSTSRTFTR SPVFTPRVIG TAVARYNFAA RDMRELSLRE GDVVKIYSRI GGDQGWWKGE TNGRVGWFPS TYVEEEGVQ //