ID Q8UUT8_DANRE Unreviewed; 154 AA. AC Q8UUT8; DT 01-MAR-2002, integrated into UniProtKB/TrEMBL. DT 01-MAR-2002, sequence version 1. DT 25-MAY-2022, entry version 98. DE SubName: Full=Isotocin {ECO:0000313|EMBL:AAL50209.1}; GN Name=oxt {ECO:0000313|ZFIN:ZDB-GENE-030407-1}; GN Synonyms=itnp {ECO:0000313|ZFIN:ZDB-GENE-030407-1}, oxtl GN {ECO:0000313|ZFIN:ZDB-GENE-030407-1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAL50209.1}; RN [1] {ECO:0000313|EMBL:AAL50209.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=12609611; DOI=10.1016/S1567-133X(02)00064-9; RA Unger J.L., Glasgow E.; RT "Expression of isotocin-neurophysin mRNA in developing zebrafish."; RL Gene Expr. Patterns 3:105-108(2003). CC -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. CC {ECO:0000256|ARBA:ARBA00007369}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY069956; AAL50209.1; -; mRNA. DR RefSeq; NP_840076.1; NM_178291.2. DR GeneID; 352920; -. DR KEGG; dre:352920; -. DR CTD; 5020; -. DR ZFIN; ZDB-GENE-030407-1; oxt. DR OrthoDB; 1548839at2759; -. DR PhylomeDB; Q8UUT8; -. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0030141; C:secretory granule; IBA:GO_Central. DR GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro. DR GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central. DR GO; GO:0050801; P:ion homeostasis; IMP:ZFIN. DR Gene3D; 2.60.9.10; -; 1. DR InterPro; IPR000981; Neurhyp_horm. DR InterPro; IPR036387; Neurhyp_horm_dom_sf. DR InterPro; IPR022423; Neurohypophysial_hormone_CS. DR PANTHER; PTHR11681; PTHR11681; 1. DR Pfam; PF00184; Hormone_5; 1. DR PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1. DR PRINTS; PR00831; NEUROPHYSIN. DR SMART; SM00003; NH; 1. DR SUPFAM; SSF49606; SSF49606; 1. DR PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1. PE 2: Evidence at transcript level; KW Amidation {ECO:0000256|ARBA:ARBA00022815}; KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, KW ECO:0000256|PIRSR:PIRSR001815-50}; Hormone {ECO:0000256|ARBA:ARBA00022702}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}. FT SIGNAL 1..20 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 21..154 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5004314835" FT DISULFID 21..26 FT /evidence="ECO:0000256|PIRSR:PIRSR001815-50" FT DISULFID 42..86 FT /evidence="ECO:0000256|PIRSR:PIRSR001815-50" FT DISULFID 45..59 FT /evidence="ECO:0000256|PIRSR:PIRSR001815-50" FT DISULFID 53..76 FT /evidence="ECO:0000256|PIRSR:PIRSR001815-50" FT DISULFID 60..66 FT /evidence="ECO:0000256|PIRSR:PIRSR001815-50" FT DISULFID 93..105 FT /evidence="ECO:0000256|PIRSR:PIRSR001815-50" FT DISULFID 99..117 FT /evidence="ECO:0000256|PIRSR:PIRSR001815-50" FT DISULFID 106..111 FT /evidence="ECO:0000256|PIRSR:PIRSR001815-50" SQ SEQUENCE 154 AA; 15935 MW; 0DF7C914D1800FAD CRC64; MSGGLLSAAA LLCLLSVCSA CYISNCPIGG KRSVQDWPIR QCMPCGPGDR GRCFGPSICC GEGIGCLVGS PETLRCLEED FLPSPCEMSG KACGYEGRCA APGVCCDSEG CSVDQSCVDG DADAAAVNQP ANSPDLLLKL LHLSSHTHPS RIHQ //