ID Q8UUT8_DANRE Unreviewed; 154 AA. AC Q8UUT8; DT 01-MAR-2002, integrated into UniProtKB/TrEMBL. DT 01-MAR-2002, sequence version 1. DT 24-JAN-2024, entry version 106. DE SubName: Full=Isotocin {ECO:0000313|EMBL:AAL50209.1}; DE SubName: Full=Oxytocin-neurophysin 1 precursor {ECO:0000313|RefSeq:NP_840076.1}; GN Name=IT-NP {ECO:0000313|RefSeq:NP_840076.1}; GN Synonyms=fj33a01 {ECO:0000313|RefSeq:NP_840076.1}, itnp GN {ECO:0000313|RefSeq:NP_840076.1}, oxtl GN {ECO:0000313|RefSeq:NP_840076.1}, wu:fj33a01 GN {ECO:0000313|RefSeq:NP_840076.1}, wu:fq40d10 GN {ECO:0000313|RefSeq:NP_840076.1}; GN OrderedLocusNames=oxt {ECO:0000313|RefSeq:NP_840076.1, GN ECO:0000313|ZFIN:ZDB-GENE-030407-1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAL50209.1}; RN [1] {ECO:0000313|EMBL:AAL50209.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=12609611; DOI=10.1016/S1567-133X(02)00064-9; RA Unger J.L., Glasgow E.; RT "Expression of isotocin-neurophysin mRNA in developing zebrafish."; RL Gene Expr. Patterns 3:105-108(2003). RN [2] {ECO:0000313|RefSeq:NP_840076.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=14752054; RA Herzog W., Sonntag C., Walderich B., Odenthal J., Maischein H.M., RA Hammerschmidt M.; RT "Genetic analysis of adenohypophysis formation in zebrafish."; RL Mol. Endocrinol. 18:1185-1195(2004). RN [3] {ECO:0000313|RefSeq:NP_840076.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=16691572; DOI=10.1002/dvdy.20848; RA Eaton J.L., Glasgow E.; RT "The zebrafish bHLH PAS transcriptional regulator, single-minded 1 (sim1), RT is required for isotocin cell development."; RL Dev. Dyn. 235:2071-2082(2006). RN [4] {ECO:0000313|RefSeq:NP_840076.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=17604726; DOI=10.1016/j.cell.2007.04.041; RA Tessmar-Raible K., Raible F., Christodoulou F., Guy K., Rembold M., RA Hausen H., Arendt D.; RT "Conserved sensory-neurosecretory cell types in annelid and fish forebrain: RT insights into hypothalamus evolution."; RL Cell 129:1389-1400(2007). RN [5] {ECO:0000313|RefSeq:NP_840076.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=17180684; DOI=10.1007/s00427-006-0123-2; RA Eaton J.L., Glasgow E.; RT "Zebrafish orthopedia (otp) is required for isotocin cell development."; RL Dev. Genes Evol. 217:149-158(2007). RN [6] {ECO:0000313|RefSeq:NP_840076.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=17373855; DOI=10.1371/journal.pbio.0050078; RA Dickmeis T., Lahiri K., Nica G., Vallone D., Santoriello C., Neumann C.J., RA Hammerschmidt M., Foulkes N.S.; RT "Glucocorticoids play a key role in circadian cell cycle rhythms."; RL PLoS Biol. 5:e78-e78(2007). RN [7] {ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23594743; DOI=10.1038/nature12111; RG Genome Reference Consortium Zebrafish; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D., RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B., RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D., RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., RA Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [8] {ECO:0000313|RefSeq:NP_840076.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28982700; DOI=10.1242/bio.030254; RA Takada N., Omae M., Sagawa F., Chi N.C., Endo S., Kozawa S., Sato T.N.; RT "Re-evaluating the functional landscape of the cardiovascular system during RT development."; RL Biol. Open 6:1756-1770(2017). RN [9] {ECO:0000313|RefSeq:NP_840076.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=29021890; RA Kim O.H., Cho H.J., Han E., Hong T.I., Ariyasiri K., Choi J.H., Hwang K.S., RA Jeong Y.M., Yang S.Y., Yu K., Park D.S., Oh H.W., Davis E.E., RA Schwartz C.E., Lee J.S., Kim H.G., Kim C.H.; RT "Zebrafish knockout of Down syndrome gene, DYRK1A, shows social impairments RT relevant to autism."; RL Mol. Autism 8:50-50(2017). RN [10] {ECO:0000313|RefSeq:NP_840076.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=29530929; DOI=10.1242/bio.031229; RA Spikol E.D., Glasgow E.; RT "Separate roles for Med12 and Wnt signaling in regulation of oxytocin RT expression. ."; RL Biol. Open 7:bio031229-bio031229(2018). RN [11] {ECO:0000313|RefSeq:NP_840076.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=29742429; RA Lohr H., Hess S., Pereira M.M.A., Reinoss P., Leibold S., Schenkel C., RA Wunderlich C.M., Kloppenburg P., Bruning J.C., Hammerschmidt M.; RT "Diet-Induced Growth Is Regulated via Acquired Leptin Resistance and RT Engages a Pomc-Somatostatin-Growth Hormone Circuit."; RL Cell Rep. 23:1728-1741(2018). RN [12] {ECO:0000313|RefSeq:NP_840076.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=29339520; RA Choi J.H., Jeong Y.M., Kim S., Lee B., Ariyasiri K., Kim H.T., Jung S.H., RA Hwang K.S., Choi T.I., Park C.O., Huh W.K., Carl M., Rosenfeld J.A., RA Raskin S., Ma A., Gecz J., Kim H.G., Kim J.S., Shin H.C., Park D.S., RA Gerlai R., Jamieson B.B., Kim J.S., Iremonger K.J., Lee S.H., Shin H.S., RA Kim C.H.; RT "Targeted knockout of a chemokine-like gene increases anxiety and fear RT responses."; RL Proc. Natl. Acad. Sci. U.S.A. 115:E1041-E1050(2018). RN [13] {ECO:0000313|RefSeq:NP_840076.1} RP IDENTIFICATION. RG RefSeq; RL Submitted (SEP-2023) to UniProtKB. CC -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. CC {ECO:0000256|ARBA:ARBA00007369}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY069956; AAL50209.1; -; mRNA. DR RefSeq; NP_840076.1; NM_178291.2. DR GeneID; 352920; -. DR KEGG; dre:352920; -. DR CTD; 5020; -. DR ZFIN; ZDB-GENE-030407-1; oxt. DR OrthoDB; 5398672at2759; -. DR PhylomeDB; Q8UUT8; -. DR Proteomes; UP000000437; Chromosome 5. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0030141; C:secretory granule; IBA:GO_Central. DR GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro. DR GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central. DR GO; GO:0050801; P:monoatomic ion homeostasis; IMP:ZFIN. DR GO; GO:0036269; P:swimming behavior; IMP:ZFIN. DR Gene3D; 2.60.9.10; Neurohypophysial hormone domain; 1. DR InterPro; IPR000981; Neurhyp_horm. DR InterPro; IPR036387; Neurhyp_horm_dom_sf. DR InterPro; IPR022423; Neurohypophysial_hormone_CS. DR PANTHER; PTHR11681; NEUROPHYSIN; 1. DR PANTHER; PTHR11681:SF5; OXYTOCIN; 1. DR Pfam; PF00184; Hormone_5; 1. DR PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1. DR PRINTS; PR00831; NEUROPHYSIN. DR SMART; SM00003; NH; 1. DR SUPFAM; SSF49606; Neurophysin II; 1. DR PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1. PE 2: Evidence at transcript level; KW Amidation {ECO:0000256|ARBA:ARBA00022815}; KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, KW ECO:0000256|PIRSR:PIRSR001815-50}; Hormone {ECO:0000256|ARBA:ARBA00022702}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}. FT SIGNAL 1..20 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 21..154 FT /evidence="ECO:0000256|SAM:SignalP, FT ECO:0000313|RefSeq:NP_840076.1" FT /id="PRO_5035035806" FT DISULFID 21..26 FT /evidence="ECO:0000256|PIRSR:PIRSR001815-50" FT DISULFID 42..86 FT /evidence="ECO:0000256|PIRSR:PIRSR001815-50" FT DISULFID 45..59 FT /evidence="ECO:0000256|PIRSR:PIRSR001815-50" FT DISULFID 53..76 FT /evidence="ECO:0000256|PIRSR:PIRSR001815-50" FT DISULFID 60..66 FT /evidence="ECO:0000256|PIRSR:PIRSR001815-50" FT DISULFID 93..105 FT /evidence="ECO:0000256|PIRSR:PIRSR001815-50" FT DISULFID 99..117 FT /evidence="ECO:0000256|PIRSR:PIRSR001815-50" FT DISULFID 106..111 FT /evidence="ECO:0000256|PIRSR:PIRSR001815-50" SQ SEQUENCE 154 AA; 15935 MW; 0DF7C914D1800FAD CRC64; MSGGLLSAAA LLCLLSVCSA CYISNCPIGG KRSVQDWPIR QCMPCGPGDR GRCFGPSICC GEGIGCLVGS PETLRCLEED FLPSPCEMSG KACGYEGRCA APGVCCDSEG CSVDQSCVDG DADAAAVNQP ANSPDLLLKL LHLSSHTHPS RIHQ //