ID Q8UTE4_9HIV1 Unreviewed; 207 AA. AC Q8UTE4; DT 01-MAR-2002, integrated into UniProtKB/TrEMBL. DT 01-MAR-2002, sequence version 1. DT 18-JUL-2018, entry version 74. DE RecName: Full=Protein Nef {ECO:0000256|RuleBase:RU000344, ECO:0000256|SAAS:SAAS01051655}; GN Name=nef {ECO:0000313|EMBL:AAL34705.1}; OS Human immunodeficiency virus 1. OC Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus. OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AAL34705.1, ECO:0000313|Proteomes:UP000152075}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:AAL34705.1, ECO:0000313|Proteomes:UP000152075} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=11991972; DOI=10.1128/JVI.76.11.5435-5451.2002; RA Novitsky V., Smith U.R., Gilbert P., McLane M.F., Chigwedere P., RA Williamson C., Ndung'u T., Klein I., Chang S.Y., Peter T., Thior I., RA Foley B.T., Gaolekwe S., Rybak N., Gaseitsiwe S., Vannberg F., RA Marlink R., Lee T.H., Essex M.; RT "Human immunodeficiency virus type 1 subtype C molecular phylogeny: RT consensus sequence for an AIDS vaccine design?"; RL J. Virol. 76:5435-5451(2002). CC -!- SUBUNIT: Homodimer. {ECO:0000256|SAAS:SAAS01051624}. CC -!- SUBCELLULAR LOCATION: Host cell membrane CC {ECO:0000256|SAAS:SAAS01051622}; Lipid-anchor CC {ECO:0000256|SAAS:SAAS01051622}; Cytoplasmic side CC {ECO:0000256|SAAS:SAAS01051622}. CC -!- SIMILARITY: Belongs to the lentivirus primate group Nef protein CC family. {ECO:0000256|RuleBase:RU000344, CC ECO:0000256|SAAS:SAAS01051605}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF443090; AAL34705.1; -; Genomic_DNA. DR ProteinModelPortal; Q8UTE4; -. DR Proteomes; UP000152075; Genome. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule. DR GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell. DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule. DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-UniRule. DR GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW. DR GO; GO:0039504; P:suppression by virus of host adaptive immune response; IEA:UniProtKB-UniRule. DR GO; GO:0046776; P:suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-UniRule. DR GO; GO:0039505; P:suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II; IEA:UniProtKB-UniRule. DR GO; GO:0039521; P:suppression by virus of host autophagy; IEA:UniProtKB-UniRule. DR Gene3D; 3.30.62.10; -; 1. DR Gene3D; 4.10.890.10; -; 1. DR HAMAP; MF_04078; NEF_HIV; 1. DR InterPro; IPR027480; HIV-1_Nef_anchor_sf. DR InterPro; IPR027481; HIV-1_Nef_core_sf. DR InterPro; IPR001558; HIV_Nef. DR Pfam; PF00469; F-protein; 1. DR SUPFAM; SSF55671; SSF55671; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000152075}; KW Host cell membrane {ECO:0000256|SAAS:SAAS01051610}; KW Host membrane {ECO:0000256|SAAS:SAAS01051635}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS01051595}; KW Lipoprotein {ECO:0000256|RuleBase:RU000344}; KW Membrane {ECO:0000256|SAAS:SAAS01051602}; KW Myristate {ECO:0000256|RuleBase:RU000344}; KW Viral immunoevasion {ECO:0000256|RuleBase:RU000344}; KW Virulence {ECO:0000256|RuleBase:RU000344}. SQ SEQUENCE 207 AA; 23618 MW; CC6F0D421A738DE0 CRC64; MGGKWSKSSL TGWPAVRERI RRTEPAAEGV GEASQDLDKH GALTTSNTAA NNADCAWLQA HEEEGEVGFP VRPQVPLRPM TFKGAFDLGF FLKEKGGLEG LIWSQKRQDI LDLWVYHTQG YFPDWQNYTP GPGVRYPLTF GWPFKLVPVD PTEVEEANEG ENNCLLHPMS QHGMDDKDRE VLKWQFDSSL VRRHMARELH PEYYKDC //