ID Q8UTE4_9HIV1 Unreviewed; 207 AA. AC Q8UTE4; DT 01-MAR-2002, integrated into UniProtKB/TrEMBL. DT 01-MAR-2002, sequence version 1. DT 16-MAY-2012, entry version 48. DE RecName: Full=Protein Nef; GN Name=nef; OS Human immunodeficiency virus 1. OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11676; RN [1] RP NUCLEOTIDE SEQUENCE. RA Novitsky V.A., McLane M.F., Chigwedere P., Ndung'u T., Klein I., RA Chang S.-Y., Peter T., Thior I., Rybak N., Gaseitsiwe S., Vannberg F., RA Marlink R., Lee T.-H., Essex M.; RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=21988475; PubMed=11991972; RX DOI=10.1128/JVI.76.11.5435-5451.2002; RA Novitsky V., Smith U.R., Gilbert P., McLane M.F., Chigwedere P., RA Williamson C., Ndung'u T., Klein I., Chang S.Y., Peter T., Thior I., RA Foley B.T., Gaolekwe S., Rybak N., Gaseitsiwe S., Vannberg F., RA Marlink R., Lee T.H., Essex M.; RT "Human immunodeficiency virus type 1 subtype C molecular phylogeny: RT consensus sequence for an AIDS vaccine design?"; RL J. Virol. 76:5435-5451(2002). CC -!- SIMILARITY: Belongs to the lentivirus primate group Nef protein CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF443090; AAL34705.1; -; Genomic_DNA. DR HSSP; P04324; 1ZEC. DR ProteinModelPortal; Q8UTE4; -. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0005525; F:GTP binding; IEA:InterPro. DR GO; GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW. DR GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW. DR Gene3D; G3DSA:3.30.62.10; HIV_Nef; 1. DR InterPro; IPR001558; HIV_Nef. DR Pfam; PF00469; F-protein; 1. DR SUPFAM; SSF55671; HIV_Nef; 1. PE 3: Inferred from homology; KW Host cell membrane; Host membrane; Host-virus interaction; KW Lipoprotein; Membrane; Myristate; Viral immunoevasion; Virulence. SQ SEQUENCE 207 AA; 23618 MW; CC6F0D421A738DE0 CRC64; MGGKWSKSSL TGWPAVRERI RRTEPAAEGV GEASQDLDKH GALTTSNTAA NNADCAWLQA HEEEGEVGFP VRPQVPLRPM TFKGAFDLGF FLKEKGGLEG LIWSQKRQDI LDLWVYHTQG YFPDWQNYTP GPGVRYPLTF GWPFKLVPVD PTEVEEANEG ENNCLLHPMS QHGMDDKDRE VLKWQFDSSL VRRHMARELH PEYYKDC //