ID THIG_AGRT5 Reviewed; 257 AA. AC Q8UCD2; DT 16-JUN-2003, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2002, sequence version 1. DT 10-JUN-2008, entry version 32. DE Thiazole biosynthesis protein thiG. GN Name=thiG; OrderedLocusNames=Atu2566; ORFNames=AGR_C_4650; OS Agrobacterium tumefaciens (strain C58 / ATCC 33970). OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; OC Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium. OX NCBI_TaxID=176299; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=21608550; PubMed=11743193; DOI=10.1126/science.1066804; RA Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., RA Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., RA Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., RA Chapman P., Clendenning J., Deatherage G., Gillet W., Grant C., RA Kutyavin T., Levy R., Li M.-J., McClelland E., Palmieri A., RA Raymond C., Rouse G., Saenphimmachak C., Wu Z., Romero P., Gordon D., RA Zhang S., Yoo H., Tao Y., Biddle P., Jung M., Krespan W., Perry M., RA Gordon-Kamm B., Liao L., Kim S., Hendrick C., Zhao Z.-Y., Dolan M., RA Chumley F., Tingey S.V., Tomb J.-F., Gordon M.P., Olson M.V., RA Nester E.W.; RT "The genome of the natural genetic engineer Agrobacterium tumefaciens RT C58."; RL Science 294:2317-2323(2001). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=21608551; PubMed=11743194; DOI=10.1126/science.1066803; RA Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., RA Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., RA Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., RA Wollam C., Allinger M., Doughty D., Scott C., Lappas C., Markelz B., RA Flanagan C., Crowell C., Gurson J., Lomo C., Sear C., Strub G., RA Cielo C., Slater S.; RT "Genome sequence of the plant pathogen and biotechnology agent RT Agrobacterium tumefaciens C58."; RL Science 294:2323-2328(2001). CC -!- FUNCTION: Required for the synthesis of the thiazole moiety of CC thiamine (By similarity). CC -!- COFACTOR: FMN (Potential). CC -!- PATHWAY: Cofactor biosynthesis; thiamine pyrophosphate CC biosynthesis. CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- SIMILARITY: Belongs to the thiG family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE007869; AAK88290.1; -; Genomic_DNA. DR PIR; A97667; A97667. DR PIR; AE2891; AE2891. DR RefSeq; NP_355505.1; -. DR GeneID; 1134604; -. DR GenomeReviews; AE007869_GR; Atu2566. DR KEGG; atc:AGR_C_4650; -. DR KEGG; atu:Atu2566; -. DR HOGENOM; Q8UCD2; -. DR GO; GO:0009228; P:thiamin biosynthetic process; IEA:HAMAP. DR HAMAP; MF_00443; -; 1. DR InterPro; IPR013785; Aldolase_TIM. DR InterPro; IPR008867; ThiG. DR Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1. DR Pfam; PF05690; ThiG; 1. PE 3: Inferred from homology; KW Complete proteome; Cytoplasm; Flavoprotein; FMN; KW Thiamine biosynthesis. FT CHAIN 1 257 Thiazole biosynthesis protein thiG. FT /FTId=PRO_0000162775. SQ SEQUENCE 257 AA; 27582 MW; 672B2E43C6D40F34 CRC64; MLTLYGREVS SRLLLGTARY PSPAVLADAV RASNTDILTI SLRREMAGAK KGGQFFELIR ELDRHILPNT AGCHTAKEAV LTAKMAREVF RTDWIKLEVI GHHDTLQPDV FALVEAAKIL CDEGFEVFPY TTDDLVVAEK LLEAGCRVLM PWCAPIGSAM GPLNLTALKS MRARFPEVPL IVDAGIGRPS HAVTVMELGY DAVLLNTAVA GAGDPVGMAE AFARAIEAGH QAYLSGPLEP RDMAVPSTPV IGTAVFS //