ID MPGS_PYRFU Reviewed; 394 AA. AC Q8U380; DT 12-FEB-2003, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2002, sequence version 1. DT 24-JAN-2024, entry version 85. DE RecName: Full=Mannosyl-3-phosphoglycerate synthase; DE Short=MPG synthase; DE Short=MPGS; DE EC=2.4.1.217; GN Name=mngA; OrderedLocusNames=PF0591; OS Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1). OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; OC Pyrococcus. OX NCBI_TaxID=186497; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1; RX PubMed=10430560; DOI=10.1093/genetics/152.4.1299; RA Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., RA DiRuggiero J., Robb F.T.; RT "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. RT horikoshii inferred from complete genomic sequences."; RL Genetics 152:1299-1305(1999). CC -!- FUNCTION: Transfers a mannosyl group from GDP-mannose to CC phosphoglycerate to form mannosyl-3-phosphoglycerate (MPG). CC {ECO:0000250}. CC -!- CATALYTIC ACTIVITY: CC Reaction=(2R)-3-phosphoglycerate + GDP-alpha-D-mannose = 2-O-(alpha-D- CC mannosyl)-3-phosphoglycerate + GDP + H(+); Xref=Rhea:RHEA:13537, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57527, ChEBI:CHEBI:57744, CC ChEBI:CHEBI:58189, ChEBI:CHEBI:58272; EC=2.4.1.217; CC -!- PATHWAY: Carbohydrate biosynthesis; 2-(alpha-D-mannosyl)-D-glycerate CC biosynthesis; 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose CC (MPG route): step 1/2. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE009950; AAL80715.1; -; Genomic_DNA. DR RefSeq; WP_011011710.1; NZ_CP023154.1. DR AlphaFoldDB; Q8U380; -. DR SMR; Q8U380; -. DR STRING; 186497.PF0591; -. DR CAZy; GT55; Glycosyltransferase Family 55. DR PaxDb; 186497-PF0591; -. DR GeneID; 41712396; -. DR KEGG; pfu:PF0591; -. DR PATRIC; fig|186497.12.peg.620; -. DR eggNOG; arCOG04158; Archaea. DR HOGENOM; CLU_028916_0_0_2; -. DR OMA; MVRLHWR; -. DR OrthoDB; 9468at2157; -. DR PhylomeDB; Q8U380; -. DR UniPathway; UPA00130; UER00192. DR Proteomes; UP000001013; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0050504; F:mannosyl-3-phosphoglycerate synthase activity; IEA:UniProtKB-EC. DR GO; GO:0051479; P:mannosylglycerate biosynthetic process; IEA:UniProtKB-UniPathway. DR CDD; cd00761; Glyco_tranf_GTA_type; 1. DR InterPro; IPR029044; Nucleotide-diphossugar_trans. DR InterPro; IPR012812; Osmo_MPG_synth. DR NCBIfam; TIGR02460; osmo_MPGsynth; 1. DR Pfam; PF09488; Osmo_MPGsynth; 1. DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1. PE 3: Inferred from homology; KW Cytoplasm; Glycosyltransferase; Reference proteome; Transferase. FT CHAIN 1..394 FT /note="Mannosyl-3-phosphoglycerate synthase" FT /id="PRO_0000059286" SQ SEQUENCE 394 AA; 45426 MW; 259598FEE665ED25 CRC64; MLLEAPVYKE IFGAVKIYEL QKVIKLDTET EDVPVYTITN IPREKIYDTL GKMAVIVPMK NEKLHLVDGV LKAIPHKCPI IIVSNSKREG PNRYRLEVDL VRHFYNLTNS KIIMVHQRDP GLAKAFQKVG YTDILDEKGN IRSGKGEGML IGILLAKAIG AEYVGFVDAD NYIPGAVNEY VKDYAAGFLM SESDYTMVRL HWRHKPKVTK GTLYFKKWGR VSEITNHYLN MLISEQTSFE TTIMVTGNAG EHAMTMKLAE IMPFSTNYSI EPYEIVYLLE RFGKWENVEE FKDVFDQGIE IFQIETLNPH FHEDKGQEHV REMILLSLAT IYHSKMASKN LKRRILNDLI EHGILKEGEE PPKLRIMRPI NEIDIEEWMK VVENNSETLL RFGL //