ID UPP_PYRFU STANDARD; PRT; 232 AA. AC Q8U1G7; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Probable uracil phosphoribosyltransferase (EC 2.4.2.9) (UMP DE pyrophosphorylase) (UPRTase). GN UPP OR PF1241. OS Pyrococcus furiosus. OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; OC Pyrococcus. OX NCBI_TaxID=2261; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Vc1 / DSM 3638 / ATCC 43587 / JCM 8422; RA Weiss R.B., Dunn D.M., Robb F.T., Brown J.R.; RT "The complete sequence of the Pyrococcus furiosus genome."; RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: UMP + diphosphate = uracil + 5-phospho- CC alpha-D-ribose 1-diphosphate. CC -!- COFACTOR: Magnesium (By similarity). CC -!- PATHWAY: Pyrimidine salvage pathway. CC -!- SIMILARITY: Belongs to the UPRTase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE010231; AAL81365.1; -. DR HAMAP; MF_01218; -; 1. DR InterPro; IPR000836; PRTransferase. DR InterPro; IPR005765; Ura_phspho_trans. DR Pfam; PF00156; Pribosyltran; 1. DR TIGRFAMs; TIGR01091; upp; 1. KW Transferase; Glycosyltransferase; Magnesium; Complete proteome. FT DOMAIN 136 148 PRPP-BINDING (BY SIMILARITY). FT DOMAIN 203 211 UMP-BINDING, URACIL PART (BY SIMILARITY). SQ SEQUENCE 232 AA; 26163 MW; CE7E6ADD397A42E0 CRC64; MIEDKRWGGV YSFEDSPYIM EILTELRDKD TDSIKFRKGL VKLGRYMGYE ITKTMDVEKV KVETPLEETE GIIVKDRRNV VIITVLRAAI PFMEGLIKVF EHARVGIVSA ARGKPPKFEI EMNYIKIPQI TPEDTVIVAD PMIATGSTLL RVLEEVKKYG TPKRTLVVGV LAAPEGITRI KEKFPEVEIF VAKIDRELND KGYILPGLGD AGDRAFGEPV KITTLPQVHY IE //