ID UPP_PYRFU Reviewed; 232 AA. AC Q8U1G7; DT 30-AUG-2002, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2002, sequence version 1. DT 06-MAR-2007, entry version 19. DE Probable uracil phosphoribosyltransferase (EC 2.4.2.9) (UMP DE pyrophosphorylase) (UPRTase). GN Name=upp; OrderedLocusNames=PF1241; OS Pyrococcus furiosus. OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; OC Pyrococcus. OX NCBI_TaxID=2261; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1; RA Weiss R.B., Dunn D.M., Robb F.T., Brown J.R.; RT "The complete sequence of the Pyrococcus furiosus genome."; RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: UMP + diphosphate = uracil + 5-phospho-alpha- CC D-ribose 1-diphosphate. CC -!- COFACTOR: Magnesium (By similarity). CC -!- PATHWAY: Pyrimidine salvage pathway. CC -!- SIMILARITY: Belongs to the UPRTase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE010231; AAL81365.1; -; Genomic_DNA. DR HSSP; Q26998; 1JLS. DR GenomeReviews; AE009950_GR; PF1241. DR KEGG; pfu:PF1241; -. DR BioCyc; PFUR186497:PF1241-MONOMER; -. DR GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP. DR GO; GO:0004845; F:uracil phosphoribosyltransferase activity; IEA:HAMAP. DR HAMAP; MF_01218; -; 1. DR InterPro; IPR000836; PRtransferase. DR InterPro; IPR005765; Ura_phspho_trans. DR Pfam; PF00156; Pribosyltran; 1. DR TIGRFAMs; TIGR01091; upp; 1. KW Complete proteome; Glycosyltransferase; Magnesium; Transferase. FT CHAIN 1 232 Probable uracil FT phosphoribosyltransferase. FT /FTId=PRO_0000120924. FT REGION 203 211 UMP-binding, uracil part (By similarity). FT MOTIF 136 148 PRPP-binding (By similarity). SQ SEQUENCE 232 AA; 26164 MW; CE7E6ADD397A42E0 CRC64; MIEDKRWGGV YSFEDSPYIM EILTELRDKD TDSIKFRKGL VKLGRYMGYE ITKTMDVEKV KVETPLEETE GIIVKDRRNV VIITVLRAAI PFMEGLIKVF EHARVGIVSA ARGKPPKFEI EMNYIKIPQI TPEDTVIVAD PMIATGSTLL RVLEEVKKYG TPKRTLVVGV LAAPEGITRI KEKFPEVEIF VAKIDRELND KGYILPGLGD AGDRAFGEPV KITTLPQVHY IE //