ID RL37_PYRFU Reviewed; 62 AA. AC Q8U0P5; DT 26-JUL-2002, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2002, sequence version 1. DT 27-NOV-2024, entry version 99. DE RecName: Full=Large ribosomal subunit protein eL37 {ECO:0000255|HAMAP-Rule:MF_00547}; DE AltName: Full=50S ribosomal protein L37e; GN Name=rpl37e {ECO:0000255|HAMAP-Rule:MF_00547}; OrderedLocusNames=PF1541; OS Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1). OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; OC Pyrococcus. OX NCBI_TaxID=186497; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1; RX PubMed=10430560; DOI=10.1093/genetics/152.4.1299; RA Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., RA DiRuggiero J., Robb F.T.; RT "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. RT horikoshii inferred from complete genomic sequences."; RL Genetics 152:1299-1305(1999). RN [2] {ECO:0007744|PDB:4V6U} RP STRUCTURE BY ELECTRON MICROSCOPY (6.60 ANGSTROMS) IN THE 70S RIBOSOME, AND RP SUBUNIT. RX PubMed=23222135; DOI=10.1093/nar/gks1259; RA Armache J.P., Anger A.M., Marquez V., Franckenberg S., Frohlich T., RA Villa E., Berninghausen O., Thomm M., Arnold G.J., Beckmann R., RA Wilson D.N.; RT "Promiscuous behaviour of archaeal ribosomal proteins: implications for RT eukaryotic ribosome evolution."; RL Nucleic Acids Res. 41:1284-1293(2013). CC -!- FUNCTION: Binds to the 23S rRNA. {ECO:0000255|HAMAP-Rule:MF_00547}. CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; CC Evidence={ECO:0000255|HAMAP-Rule:MF_00547}; CC Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-Rule:MF_00547}; CC -!- SUBUNIT: Part of the 50S ribosomal subunit. CC {ECO:0000269|PubMed:23222135}. CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL37 family. CC {ECO:0000255|HAMAP-Rule:MF_00547}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE009950; AAL81665.1; -; Genomic_DNA. DR RefSeq; WP_014835439.1; NZ_CP023154.1. DR PDB; 4V4N; EM; 9.00 A; e=1-62. DR PDB; 4V6U; EM; 6.60 A; Be=1-62. DR PDBsum; 4V4N; -. DR PDBsum; 4V6U; -. DR AlphaFoldDB; Q8U0P5; -. DR SMR; Q8U0P5; -. DR STRING; 186497.PF1541; -. DR PaxDb; 186497-PF1541; -. DR GeneID; 41713360; -. DR KEGG; pfu:PF1541; -. DR PATRIC; fig|186497.12.peg.1607; -. DR eggNOG; arCOG04126; Archaea. DR HOGENOM; CLU_208825_0_0_2; -. DR OrthoDB; 5619at2157; -. DR PhylomeDB; Q8U0P5; -. DR Proteomes; UP000001013; Chromosome. DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW. DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW. DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW. DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule. DR FunFam; 2.20.25.30:FF:000003; 50S ribosomal protein L37e; 1. DR Gene3D; 2.20.25.30; -; 1. DR HAMAP; MF_00547; Ribosomal_eL37; 1. DR InterPro; IPR001569; Ribosomal_eL37. DR InterPro; IPR011331; Ribosomal_eL37/eL43. DR InterPro; IPR018267; Ribosomal_eL37_CS. DR InterPro; IPR011332; Ribosomal_zn-bd. DR Pfam; PF01907; Ribosomal_L37e; 1. DR SUPFAM; SSF57829; Zn-binding ribosomal proteins; 1. DR PROSITE; PS01077; RIBOSOMAL_L37E; 1. PE 1: Evidence at protein level; KW 3D-structure; Metal-binding; Reference proteome; Ribonucleoprotein; KW Ribosomal protein; RNA-binding; rRNA-binding; Zinc; Zinc-finger. FT CHAIN 1..62 FT /note="Large ribosomal subunit protein eL37" FT /id="PRO_0000139735" FT ZN_FING 20..38 FT /note="C4-type" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00547" FT BINDING 20 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00547" FT BINDING 23 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00547" FT BINDING 35 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00547" FT BINDING 38 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00547" SQ SEQUENCE 62 AA; 7223 MW; 99E0A2AF4954E439 CRC64; MGSGTATFGK RNSTPTHIRC RRCGRVSYNV KKGYCAACGF GRSRRLRKYR WSKKWKKKKN AH //