ID   NSUN6_HUMAN             Reviewed;         469 AA.
AC   Q8TEA1; B0YJ54;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   20-JAN-2016, entry version 118.
DE   RecName: Full=Putative methyltransferase NSUN6;
DE            EC=2.1.1.-;
DE   AltName: Full=NOL1/NOP2/Sun and PUA domain-containing protein 1;
DE   AltName: Full=NOL1/NOP2/Sun domain family member 6;
GN   Name=NSUN6; Synonyms=NOPD1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG   NHLBI resequencing and genotyping service (RS&G);
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-419, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19608861; DOI=10.1126/science.1175371;
RA   Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M.,
RA   Walther T.C., Olsen J.V., Mann M.;
RT   "Lysine acetylation targets protein complexes and co-regulates major
RT   cellular functions.";
RL   Science 325:834-840(2009).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- FUNCTION: May have S-adenosyl-L-methionine-dependent methyl-
CC       transferase activity. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding
CC       methyltransferase superfamily. RsmB/NOP family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01023}.
CC   -!- SIMILARITY: Contains 1 PUA domain. {ECO:0000255|PROSITE-
CC       ProRule:PRU00161}.
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DR   EMBL; AK074323; BAB85051.1; -; mRNA.
DR   EMBL; EF445003; ACA06032.1; -; Genomic_DNA.
DR   EMBL; EF445003; ACA06033.1; -; Genomic_DNA.
DR   EMBL; AL512641; CAH70493.1; -; Genomic_DNA.
DR   EMBL; AL450384; CAH70493.1; JOINED; Genomic_DNA.
DR   EMBL; AL450384; CAH73205.1; -; Genomic_DNA.
DR   EMBL; AL512641; CAH73205.1; JOINED; Genomic_DNA.
DR   EMBL; CH471072; EAW86191.1; -; Genomic_DNA.
DR   EMBL; BC035778; AAH35778.1; -; mRNA.
DR   CCDS; CCDS7130.1; -.
DR   RefSeq; NP_872349.1; NM_182543.3.
DR   UniGene; Hs.396175; -.
DR   UniGene; Hs.655091; -.
DR   UniGene; Hs.731893; -.
DR   ProteinModelPortal; Q8TEA1; -.
DR   SMR; Q8TEA1; 205-426.
DR   BioGrid; 128682; 3.
DR   STRING; 9606.ENSP00000366519; -.
DR   iPTMnet; Q8TEA1; -.
DR   PhosphoSite; Q8TEA1; -.
DR   BioMuta; NSUN6; -.
DR   DMDM; 74751440; -.
DR   MaxQB; Q8TEA1; -.
DR   PaxDb; Q8TEA1; -.
DR   PeptideAtlas; Q8TEA1; -.
DR   PRIDE; Q8TEA1; -.
DR   DNASU; 221078; -.
DR   Ensembl; ENST00000377304; ENSP00000366519; ENSG00000241058.
DR   GeneID; 221078; -.
DR   KEGG; hsa:221078; -.
DR   UCSC; uc010qcp.1; human.
DR   CTD; 221078; -.
DR   GeneCards; NSUN6; -.
DR   HGNC; HGNC:23529; NSUN6.
DR   HPA; HPA045902; -.
DR   neXtProt; NX_Q8TEA1; -.
DR   PharmGKB; PA134986220; -.
DR   eggNOG; KOG1122; Eukaryota.
DR   eggNOG; COG0144; LUCA.
DR   GeneTree; ENSGT00660000095341; -.
DR   HOGENOM; HOG000224258; -.
DR   HOVERGEN; HBG060395; -.
DR   InParanoid; Q8TEA1; -.
DR   OMA; QVAWALT; -.
DR   OrthoDB; EOG7B8S4B; -.
DR   PhylomeDB; Q8TEA1; -.
DR   TreeFam; TF324225; -.
DR   GenomeRNAi; 221078; -.
DR   NextBio; 91183; -.
DR   PRO; PR:Q8TEA1; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; Q8TEA1; -.
DR   CleanEx; HS_NSUN6; -.
DR   ExpressionAtlas; Q8TEA1; baseline and differential.
DR   Genevisible; Q8TEA1; HS.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.130.10; -; 1.
DR   Gene3D; 3.40.50.150; -; 2.
DR   InterPro; IPR018314; Fmu/NOL1/Nop2p_CS.
DR   InterPro; IPR001678; MeTrfase_RsmB/NOP2.
DR   InterPro; IPR002478; PUA.
DR   InterPro; IPR015947; PUA-like_domain.
DR   InterPro; IPR023267; RCMT.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   Pfam; PF01189; Nol1_Nop2_Fmu; 1.
DR   PRINTS; PR02008; RCMTFAMILY.
DR   SUPFAM; SSF53335; SSF53335; 2.
DR   SUPFAM; SSF88697; SSF88697; 1.
DR   PROSITE; PS01153; NOL1_NOP2_SUN; 1.
DR   PROSITE; PS50890; PUA; 1.
DR   PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Complete proteome; Methyltransferase; Reference proteome;
KW   RNA-binding; S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    469       Putative methyltransferase NSUN6.
FT                                /FTId=PRO_0000263114.
FT   DOMAIN      111    203       PUA. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00161}.
FT   REGION      242    248       S-adenosyl-L-methionine binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01023}.
FT   ACT_SITE    373    373       Nucleophile. {ECO:0000255|PROSITE-
FT                                ProRule:PRU01023}.
FT   BINDING     266    266       S-adenosyl-L-methionine.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01023}.
FT   BINDING     293    293       S-adenosyl-L-methionine.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01023}.
FT   BINDING     323    323       S-adenosyl-L-methionine.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01023}.
FT   MOD_RES     419    419       N6-acetyllysine.
FT                                {ECO:0000244|PubMed:19608861}.
SQ   SEQUENCE   469 AA;  51770 MW;  EB6D383915547CF6 CRC64;
     MSIFPKISLR PEVENYLKEG FMNKEIVTAL GKQEAERKFE TLLKHLSHPP SFTTVRVNTH
     LASVQHVKNL LLDELQKQFN GLSVPILQHP DLQDVLLIPV IGPRKNIKKQ QCEAIVGAQC
     GNAVLRGAHV YAPGIVSASQ FMKAGDVISV YSDIKGKCKK GAKEFDGTKV FLGNGISELS
     RKEIFSGLPE LKGMGIRMTE PVYLSPSFDS VLPRYLFLQN LPSALVSHVL NPQPGEKILD
     LCAAPGGKTT HIAALMHDQG EVIALDKIFN KVEKIKQNAL LLGLNSIRAF CFDGTKAVKL
     DMVEDTEGEP PFLPESFDRI LLDAPCSGMG QRPNMACTWS VKEVASYQPL QRKLFTAAVQ
     LLKPEGVLVY STCTITLAEN EEQVAWALTK FPCLQLQPQE PQIGGEGMRG AGLSCEQLKQ
     LQRFDPSAVP LPDTDMDSLR EARREDMLRL ANKDSIGFFI AKFVKCKST
//