ID   PLPR1_HUMAN             Reviewed;         325 AA.
AC   Q8TBJ4; Q5VX23; Q9NXE2;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   29-SEP-2021, entry version 145.
DE   RecName: Full=Phospholipid phosphatase-related protein type 1 {ECO:0000305};
DE   AltName: Full=Lipid phosphate phosphatase-related protein type 1 {ECO:0000303|Ref.2};
DE   AltName: Full=Plasticity-related gene 3 protein {ECO:0000305|PubMed:14750979};
DE            Short=PRG-3 {ECO:0000303|PubMed:14750979};
GN   Name=PLPPR1 {ECO:0000312|HGNC:HGNC:25993};
GN   Synonyms=LPPR1 {ECO:0000303|Ref.2}, PRG3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=14750979; DOI=10.1046/j.1460-9568.2003.03078.x;
RA   Savaskan N.E., Brauer A.U., Nitsch R.;
RT   "Molecular cloning and expression regulation of PRG-3, a new member of the
RT   plasticity-related gene family.";
RL   Eur. J. Neurosci. 19:212-220(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Morris A.J., Sigal Y.J., McDermott M., Sciorra V.A.;
RT   "Lipid phosphate phosphatase related proteins.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q8TBJ4; P23560-2: BDNF; NbExp=3; IntAct=EBI-18063495, EBI-12275524;
CC       Q8TBJ4; P28799: GRN; NbExp=3; IntAct=EBI-18063495, EBI-747754;
CC       Q8TBJ4; O60333-2: KIF1B; NbExp=3; IntAct=EBI-18063495, EBI-10975473;
CC       Q8TBJ4; O15243: LEPROT; NbExp=3; IntAct=EBI-18063495, EBI-15672507;
CC       Q8TBJ4; P16284: PECAM1; NbExp=3; IntAct=EBI-18063495, EBI-716404;
CC       Q8TBJ4; O43933: PEX1; NbExp=3; IntAct=EBI-18063495, EBI-988601;
CC       Q8TBJ4; P26678: PLN; NbExp=3; IntAct=EBI-18063495, EBI-692836;
CC       Q8TBJ4; P60891: PRPS1; NbExp=3; IntAct=EBI-18063495, EBI-749195;
CC       Q8TBJ4; P54725: RAD23A; NbExp=3; IntAct=EBI-18063495, EBI-746453;
CC       Q8TBJ4; Q9Y6X1: SERP1; NbExp=3; IntAct=EBI-18063495, EBI-10329948;
CC       Q8TBJ4; P50454: SERPINH1; NbExp=3; IntAct=EBI-18063495, EBI-350723;
CC       Q8TBJ4; Q9BRI3: SLC30A2; NbExp=3; IntAct=EBI-18063495, EBI-8644112;
CC       Q8TBJ4; P37173: TGFBR2; NbExp=3; IntAct=EBI-18063495, EBI-296151;
CC       Q8TBJ4; Q6ZT21: TMPPE; NbExp=3; IntAct=EBI-18063495, EBI-11724433;
CC       Q8TBJ4; O76024: WFS1; NbExp=3; IntAct=EBI-18063495, EBI-720609;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the PA-phosphatase related phosphoesterase
CC       family. {ECO:0000305}.
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DR   EMBL; AY337718; AAQ73539.1; -; mRNA.
DR   EMBL; AY304515; AAP72152.1; -; mRNA.
DR   EMBL; AK000307; BAA91072.1; -; mRNA.
DR   EMBL; AL359893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL161631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471105; EAW58938.1; -; Genomic_DNA.
DR   EMBL; BC022465; AAH22465.1; -; mRNA.
DR   CCDS; CCDS6751.1; -.
DR   RefSeq; NP_060223.2; NM_017753.2.
DR   RefSeq; NP_997182.1; NM_207299.1.
DR   BioGRID; 120234; 17.
DR   IntAct; Q8TBJ4; 23.
DR   STRING; 9606.ENSP00000364008; -.
DR   DEPOD; PLPPR1; -.
DR   GlyGen; Q8TBJ4; 3 sites.
DR   iPTMnet; Q8TBJ4; -.
DR   PhosphoSitePlus; Q8TBJ4; -.
DR   BioMuta; PLPPR1; -.
DR   DMDM; 74751381; -.
DR   MassIVE; Q8TBJ4; -.
DR   PaxDb; Q8TBJ4; -.
DR   PeptideAtlas; Q8TBJ4; -.
DR   PRIDE; Q8TBJ4; -.
DR   ProteomicsDB; 74019; -.
DR   ABCD; Q8TBJ4; 3 sequenced antibodies.
DR   Antibodypedia; 14633; 45 antibodies.
DR   DNASU; 54886; -.
DR   Ensembl; ENST00000374874; ENSP00000364008; ENSG00000148123.
DR   Ensembl; ENST00000395056; ENSP00000378496; ENSG00000148123.
DR   Ensembl; ENST00000611695; ENSP00000478338; ENSG00000276539.
DR   Ensembl; ENST00000614834; ENSP00000477959; ENSG00000276539.
DR   GeneID; 54886; -.
DR   KEGG; hsa:54886; -.
DR   UCSC; uc004bbb.4; human.
DR   CTD; 54886; -.
DR   DisGeNET; 54886; -.
DR   GeneCards; PLPPR1; -.
DR   HGNC; HGNC:25993; PLPPR1.
DR   HPA; ENSG00000148123; Group enriched (brain, kidney).
DR   neXtProt; NX_Q8TBJ4; -.
DR   OpenTargets; ENSG00000148123; -.
DR   VEuPathDB; HostDB:ENSG00000148123; -.
DR   eggNOG; KOG3030; Eukaryota.
DR   GeneTree; ENSGT00940000158875; -.
DR   HOGENOM; CLU_021458_1_0_1; -.
DR   InParanoid; Q8TBJ4; -.
DR   OMA; GEISMYV; -.
DR   OrthoDB; 1621899at2759; -.
DR   PhylomeDB; Q8TBJ4; -.
DR   BRENDA; 3.1.3.4; 2681.
DR   PathwayCommons; Q8TBJ4; -.
DR   Reactome; R-HSA-419408; Lysosphingolipid and LPA receptors.
DR   SIGNOR; Q8TBJ4; -.
DR   BioGRID-ORCS; 54886; 4 hits in 966 CRISPR screens.
DR   ChiTaRS; PLPPR1; human.
DR   GenomeRNAi; 54886; -.
DR   Pharos; Q8TBJ4; Tdark.
DR   PRO; PR:Q8TBJ4; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q8TBJ4; protein.
DR   Bgee; ENSG00000148123; Expressed in forebrain and 138 other tissues.
DR   ExpressionAtlas; Q8TBJ4; baseline and differential.
DR   Genevisible; Q8TBJ4; HS.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0042577; F:lipid phosphatase activity; IBA:GO_Central.
DR   GO; GO:0008195; F:phosphatidate phosphatase activity; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR   GO; GO:0046839; P:phospholipid dephosphorylation; IBA:GO_Central.
DR   GO; GO:0006644; P:phospholipid metabolic process; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   InterPro; IPR028678; LPPR1.
DR   InterPro; IPR036938; P_Acid_Pase_2/haloperoxi_sf.
DR   InterPro; IPR000326; P_Acid_Pase_2/haloperoxidase.
DR   InterPro; IPR043216; PLPP.
DR   PANTHER; PTHR10165; PTHR10165; 1.
DR   PANTHER; PTHR10165:SF41; PTHR10165:SF41; 1.
DR   Pfam; PF01569; PAP2; 1.
DR   SMART; SM00014; acidPPc; 1.
DR   SUPFAM; SSF48317; SSF48317; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..325
FT                   /note="Phospholipid phosphatase-related protein type 1"
FT                   /id="PRO_0000317532"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         307
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BFZ2"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        163
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        316
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        105
FT                   /note="Q -> R (in Ref. 3; BAA91072)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   325 AA;  35795 MW;  5FC7B9381B78D116 CRC64;
     MAVGNNTQRS YSIIPCFIFV ELVIMAGTVL LAYYFECTDT FQVHIQGFFC QDGDLMKPYP
     GTEEESFITP LVLYCVLAAT PTAIIFIGEI SMYFIKSTRE SLIAQEKTIL TGECCYLNPL
     LRRIIRFTGV FAFGLFATDI FVNAGQVVTG HLTPYFLTVC KPNYTSADCQ AHHQFINNGN
     ICTGDLEVIE KARRSFPSKH AALSIYSALY ATMYITSTIK TKSSRLAKPV LCLGTLCTAF
     LTGLNRVSEY RNHCSDVIAG FILGTAVALF LGMCVVHNFK GTQGSPSKPK PEDPRGVPLM
     AFPRIESPLE TLSAQNHSAS MTEVT
//