ID Q8T9L0_DROME Unreviewed; 371 AA. AC Q8T9L0; DT 01-JUN-2002, integrated into UniProtKB/TrEMBL. DT 01-JUN-2002, sequence version 1. DT 03-AUG-2022, entry version 95. DE RecName: Full=Dynamin GTPase {ECO:0000256|ARBA:ARBA00011980}; DE EC=3.6.5.5 {ECO:0000256|ARBA:ARBA00011980}; GN Name=Drp1 {ECO:0000313|FlyBase:FBgn0026479}; GN Synonyms=noodle {ECO:0000313|FlyBase:FBgn0026479}; GN ORFNames=CG3210 {ECO:0000313|EMBL:AAL39391.1, GN ECO:0000313|FlyBase:FBgn0026479}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAL39391.1}; RN [1] {ECO:0000313|EMBL:AAL39391.1} RP NUCLEOTIDE SEQUENCE. RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., RA Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., RA Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J., Pacleb J., RA Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., RA Rubin G.M., Celniker S.; RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.5; CC Evidence={ECO:0000256|ARBA:ARBA00001837}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY069246; AAL39391.1; -; mRNA. DR PeptideAtlas; Q8T9L0; -. DR FlyBase; FBgn0026479; Drp1. DR VEuPathDB; VectorBase:FBgn0026479; -. DR HOGENOM; CLU_008964_5_0_1; -. DR ChiTaRS; Drp1; fly. DR ExpressionAtlas; Q8T9L0; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0016020; C:membrane; IBA:GO_Central. DR GO; GO:0005874; C:microtubule; IBA:GO_Central. DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central. DR GO; GO:0005525; F:GTP binding; IEA:InterPro. DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central. DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW. DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central. DR GO; GO:0000266; P:mitochondrial fission; IBA:GO_Central. DR GO; GO:0051646; P:mitochondrion localization; IMP:FlyBase. DR GO; GO:0007005; P:mitochondrion organization; IMP:FlyBase. DR GO; GO:0016559; P:peroxisome fission; IEA:InterPro. DR GO; GO:0090141; P:positive regulation of mitochondrial fission; IMP:FlyBase. DR GO; GO:0090140; P:regulation of mitochondrial fission; IMP:FlyBase. DR GO; GO:0030382; P:sperm mitochondrion organization; IMP:FlyBase. DR GO; GO:0007370; P:ventral furrow formation; IMP:FlyBase. DR InterPro; IPR030556; DNM1L. DR InterPro; IPR022812; Dynamin. DR InterPro; IPR000375; Dynamin_stalk. DR InterPro; IPR003130; GED. DR InterPro; IPR020850; GED_dom. DR PANTHER; PTHR11566; PTHR11566; 1. DR PANTHER; PTHR11566:SF39; PTHR11566:SF39; 1. DR Pfam; PF01031; Dynamin_M; 1. DR Pfam; PF02212; GED; 1. DR SMART; SM00302; GED; 1. DR PROSITE; PS51388; GED; 1. PE 2: Evidence at transcript level; KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128}. FT DOMAIN 279..370 FT /note="GED" FT /evidence="ECO:0000259|PROSITE:PS51388" FT REGION 151..252 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 151..226 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 233..250 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 371 AA; 42389 MW; 9C8B29593CF20BBE CRC64; MGYIFHETFG RTLDSIHPLA GLSKMDILTA IRNATGPRPA LFVPEVSFEL LVKRQIRRLE EPSLRCVELI HEEMQRIVQH CGNEVQQEML RFPKLHEKIV DVVTQLLRRR LPHTNVMVEN IVAIELAYIN TKHPDFHKDA ALVPSLLKTD SDPYSQINLG QRRANTPRNH MSPQISSHSA GSQQPQQQQP PQPSSSQQQY SQVHEQNHVA ENSTPSMAST WLSNILPPAP TRPDSIENST NNTPVHNNIV SPVKPVNLLP DVPANHNPRR LTDKEQKDCD VIEHLIKSYF YIVRKSIQDS VPKAIMHFLV NYVKDNLQSE LVTHLYKSDK AETLLNESDH IAVRRKEAAD MLKALTRANH IISEIRETHM W //