ID Q8T9L0_DROME Unreviewed; 371 AA. AC Q8T9L0; DT 01-JUN-2002, integrated into UniProtKB/TrEMBL. DT 01-JUN-2002, sequence version 1. DT 29-SEP-2021, entry version 93. DE RecName: Full=Dynamin GTPase {ECO:0000256|ARBA:ARBA00011980}; DE EC=3.6.5.5 {ECO:0000256|ARBA:ARBA00011980}; GN Name=Drp1 {ECO:0000313|FlyBase:FBgn0026479}; GN Synonyms=noodle {ECO:0000313|FlyBase:FBgn0026479}; GN ORFNames=CG3210 {ECO:0000313|EMBL:AAL39391.1, GN ECO:0000313|FlyBase:FBgn0026479}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAL39391.1}; RN [1] {ECO:0000313|EMBL:AAL39391.1} RP NUCLEOTIDE SEQUENCE. RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., RA Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., RA Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J., Pacleb J., RA Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., RA Rubin G.M., Celniker S.; RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.5; CC Evidence={ECO:0000256|ARBA:ARBA00001837}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY069246; AAL39391.1; -; mRNA. DR PeptideAtlas; Q8T9L0; -. DR FlyBase; FBgn0026479; Drp1. DR VEuPathDB; VectorBase:FBgn0026479; -. DR HOGENOM; CLU_008964_5_0_1; -. DR ChiTaRS; Drp1; fly. DR Bgee; FBgn0026479; Expressed in embryonic/larval hemocyte (Drosophila) and 38 other tissues. DR ExpressionAtlas; Q8T9L0; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0016020; C:membrane; IBA:GO_Central. DR GO; GO:0005875; C:microtubule associated complex; ISS:FlyBase. DR GO; GO:0031966; C:mitochondrial membrane; IBA:GO_Central. DR GO; GO:0098793; C:presynapse; IEA:GOC. DR GO; GO:0005525; F:GTP binding; IEA:InterPro. DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central. DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW. DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central. DR GO; GO:0003374; P:dynamin family protein polymerization involved in mitochondrial fission; IBA:GO_Central. DR GO; GO:0048312; P:intracellular distribution of mitochondria; IBA:GO_Central. DR GO; GO:0061025; P:membrane fusion; IBA:GO_Central. DR GO; GO:0000266; P:mitochondrial fission; IBA:GO_Central. DR GO; GO:0043653; P:mitochondrial fragmentation involved in apoptotic process; IBA:GO_Central. DR GO; GO:0051646; P:mitochondrion localization; IMP:FlyBase. DR GO; GO:0007005; P:mitochondrion organization; IMP:FlyBase. DR GO; GO:0016559; P:peroxisome fission; IEA:InterPro. DR GO; GO:0090141; P:positive regulation of mitochondrial fission; IMP:FlyBase. DR GO; GO:1903146; P:regulation of autophagy of mitochondrion; IBA:GO_Central. DR GO; GO:0090140; P:regulation of mitochondrial fission; IMP:FlyBase. DR GO; GO:0030382; P:sperm mitochondrion organization; IMP:FlyBase. DR GO; GO:0016185; P:synaptic vesicle budding from presynaptic endocytic zone membrane; NAS:FlyBase. DR GO; GO:0007370; P:ventral furrow formation; IMP:FlyBase. DR InterPro; IPR030556; DNM1L. DR InterPro; IPR022812; Dynamin_SF. DR InterPro; IPR000375; Dynamin_stalk. DR InterPro; IPR003130; GED. DR InterPro; IPR020850; GED_dom. DR PANTHER; PTHR11566; PTHR11566; 1. DR PANTHER; PTHR11566:SF39; PTHR11566:SF39; 1. DR Pfam; PF01031; Dynamin_M; 1. DR Pfam; PF02212; GED; 1. DR SMART; SM00302; GED; 1. DR PROSITE; PS51388; GED; 1. PE 2: Evidence at transcript level; KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128}. FT DOMAIN 279..370 FT /note="GED" FT /evidence="ECO:0000259|PROSITE:PS51388" FT REGION 151..252 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 151..226 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 233..250 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 371 AA; 42389 MW; 9C8B29593CF20BBE CRC64; MGYIFHETFG RTLDSIHPLA GLSKMDILTA IRNATGPRPA LFVPEVSFEL LVKRQIRRLE EPSLRCVELI HEEMQRIVQH CGNEVQQEML RFPKLHEKIV DVVTQLLRRR LPHTNVMVEN IVAIELAYIN TKHPDFHKDA ALVPSLLKTD SDPYSQINLG QRRANTPRNH MSPQISSHSA GSQQPQQQQP PQPSSSQQQY SQVHEQNHVA ENSTPSMAST WLSNILPPAP TRPDSIENST NNTPVHNNIV SPVKPVNLLP DVPANHNPRR LTDKEQKDCD VIEHLIKSYF YIVRKSIQDS VPKAIMHFLV NYVKDNLQSE LVTHLYKSDK AETLLNESDH IAVRRKEAAD MLKALTRANH IISEIRETHM W //