ID Q8SXB0_DROME Unreviewed; 1688 AA. AC Q8SXB0; Q9VF61; DT 01-JUN-2002, integrated into UniProtKB/TrEMBL. DT 01-JUN-2002, sequence version 1. DT 03-MAY-2023, entry version 189. DE SubName: Full=ADAM metallopeptidase with thrombospondin type 1 motif A, isoform B {ECO:0000313|EMBL:AAS65157.1}; DE EC=3.4.24.- {ECO:0000313|EMBL:AAS65157.1}; DE SubName: Full=GH16393p {ECO:0000313|EMBL:AAM11069.1}; GN Name=AdamTS-A {ECO:0000313|EMBL:AAS65157.1, GN ECO:0000313|FlyBase:FBgn0286071}; GN Synonyms=CT19033 {ECO:0000313|EMBL:AAS65157.1}, Dmel\CG14869 GN {ECO:0000313|EMBL:AAS65157.1}, l(3)89Aa {ECO:0000313|EMBL:AAS65157.1}, GN rnwy {ECO:0000313|EMBL:AAS65157.1}; GN ORFNames=CG14869 {ECO:0000313|EMBL:AAS65157.1, GN ECO:0000313|FlyBase:FBgn0286071}, CG6107 GN {ECO:0000313|EMBL:AAM11069.1}, Dmel_CG14869 GN {ECO:0000313|EMBL:AAS65157.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAM11069.1}; RN [1] {ECO:0000313|EMBL:AAS65157.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAS65157.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AAS65157.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., Harris N.L., RA Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., RA Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AAS65157.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:AAS65157.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AAM11069.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Berkeley {ECO:0000313|EMBL:AAM11069.1}; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R., RA Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A., RA Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S., RA Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S.; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:AAS65157.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [8] {ECO:0000313|EMBL:AAS65157.1} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:AAS65157.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [10] {ECO:0000313|EMBL:AAS65157.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [11] {ECO:0000313|EMBL:AAS65157.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109357; DOI=.1534/g3.115.018929; RG FlyBase Consortium; RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E., RA Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M., RA Gelbart W.M., null; RT "Gene Model Annotations for Drosophila melanogaster: Impact of High- RT Throughput Data."; RL G3 (Bethesda) 5:1721-1736(2015). RN [12] {ECO:0000313|EMBL:AAS65157.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109356; DOI=.1534/g3.115.018937; RG FlyBase Consortium; RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E., RA Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M., RA null; RT "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders."; RL G3 (Bethesda) 5:1737-1749(2015). RN [13] {ECO:0000313|EMBL:AAS65157.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25589440; RA Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E., RA Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M., RA Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M., RA de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M., RA Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M., RA Karpen G.H., Celniker S.E.; RT "The Release 6 reference sequence of the Drosophila melanogaster genome."; RL Genome Res. 25:445-458(2015). RN [14] {ECO:0000313|EMBL:AAS65157.1} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., RA Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases. RN [15] {ECO:0000313|EMBL:AAS65157.1} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases. CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; CC Evidence={ECO:0000256|PIRSR:PIRSR613273-2}; CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR613273-2}; CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular CC matrix {ECO:0000256|ARBA:ARBA00004498}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00276}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY094716; AAM11069.1; -; mRNA. DR EMBL; AE014297; AAS65157.1; -; Genomic_DNA. DR RefSeq; NP_996218.1; NM_206496.2. DR SMR; Q8SXB0; -. DR STRING; 7227.FBpp0082614; -. DR MEROPS; M12.A03; -. DR EnsemblMetazoa; FBtr0083160; FBpp0082614; FBgn0286071. DR GeneID; 41887; -. DR UCSC; CG14869-RB; d. melanogaster. DR AGR; FB:FBgn0286071; -. DR CTD; 41887; -. DR FlyBase; FBgn0286071; AdamTS-A. DR VEuPathDB; VectorBase:FBgn0286071; -. DR eggNOG; KOG3538; Eukaryota. DR GeneTree; ENSGT00940000167121; -. DR OMA; DNDFQFA; -. DR OrthoDB; 2910701at2759; -. DR Reactome; R-DME-1474228; Degradation of the extracellular matrix. DR Reactome; R-DME-5173214; O-glycosylation of TSR domain-containing proteins. DR BioGRID-ORCS; 41887; 0 hits in 3 CRISPR screens. DR GenomeRNAi; 41887; -. DR Proteomes; UP000000803; Chromosome 3R. DR Bgee; FBgn0286071; Expressed in crop (Drosophila) and 28 other tissues. DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0004222; F:metalloendopeptidase activity; IBA:GO_Central. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0007427; P:epithelial cell migration, open tracheal system; IMP:FlyBase. DR GO; GO:0030198; P:extracellular matrix organization; IMP:FlyBase. DR GO; GO:0007436; P:larval salivary gland morphogenesis; IMP:FlyBase. DR GO; GO:0008078; P:mesodermal cell migration; IMP:FlyBase. DR GO; GO:0007280; P:pole cell migration; IMP:FlyBase. DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW. DR CDD; cd04273; ZnMc_ADAMTS_like; 1. DR Gene3D; 2.60.120.830; -; 1. DR Gene3D; 3.40.1620.60; -; 1. DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1. DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2. DR InterPro; IPR013273; ADAMTS/ADAMTS-like. DR InterPro; IPR041645; ADAMTS_CR_2. DR InterPro; IPR045371; ADAMTS_CR_3. DR InterPro; IPR010294; ADAMTS_spacer1. DR InterPro; IPR024079; MetalloPept_cat_dom_sf. DR InterPro; IPR012314; Pept_M12B_GON-ADAMTSs. DR InterPro; IPR001590; Peptidase_M12B. DR InterPro; IPR002870; Peptidase_M12B_N. DR InterPro; IPR000884; TSP1_rpt. DR InterPro; IPR036383; TSP1_rpt_sf. DR PANTHER; PTHR13723:SF278; ADAM METALLOPEPTIDASE WITH THROMBOSPONDIN TYPE 1 MOTIF A, ISOFORM B; 1. DR PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1. DR Pfam; PF17771; ADAMTS_CR_2; 1. DR Pfam; PF19236; ADAMTS_CR_3; 1. DR Pfam; PF05986; ADAMTS_spacer1; 1. DR Pfam; PF08685; GON; 1. DR Pfam; PF01562; Pep_M12B_propep; 1. DR Pfam; PF13688; Reprolysin_5; 1. DR Pfam; PF19030; TSP1_ADAMTS; 2. DR Pfam; PF00090; TSP_1; 2. DR PRINTS; PR01857; ADAMTSFAMILY. DR SMART; SM00209; TSP1; 3. DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1. DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 3. DR PROSITE; PS50215; ADAM_MEPRO; 1. DR PROSITE; PS51046; GON; 1. DR PROSITE; PS50092; TSP1; 3. PE 2: Evidence at transcript level; KW Calcium {ECO:0000256|PIRSR:PIRSR613273-2}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, KW ECO:0000256|PIRSR:PIRSR613273-3}; KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:AAS65157.1}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, KW ECO:0000256|PIRSR:PIRSR613273-2}; KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049}; KW Protease {ECO:0000256|ARBA:ARBA00022670}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}; KW Signal {ECO:0000256|ARBA:ARBA00022729}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}; KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR613273-2}. FT TRANSMEM 160..181 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 455..659 FT /note="Peptidase M12B" FT /evidence="ECO:0000259|PROSITE:PS50215" FT DOMAIN 1492..1688 FT /note="GON" FT /evidence="ECO:0000259|PROSITE:PS51046" FT REGION 188..231 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1449..1496 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 188..202 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1461..1490 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT ACT_SITE 591 FT /evidence="ECO:0000256|PIRSR:PIRSR613273-1, FT ECO:0000256|PROSITE-ProRule:PRU00276" FT BINDING 458 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0000256|PIRSR:PIRSR613273-2" FT BINDING 458 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="1" FT /evidence="ECO:0000256|PIRSR:PIRSR613273-2" FT BINDING 538 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="1" FT /evidence="ECO:0000256|PIRSR:PIRSR613273-2" FT BINDING 590 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_note="catalytic" FT /evidence="ECO:0000256|PIRSR:PIRSR613273-2, FT ECO:0000256|PROSITE-ProRule:PRU00276" FT BINDING 594 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_note="catalytic" FT /evidence="ECO:0000256|PIRSR:PIRSR613273-2, FT ECO:0000256|PROSITE-ProRule:PRU00276" FT BINDING 600 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_note="catalytic" FT /evidence="ECO:0000256|PIRSR:PIRSR613273-2, FT ECO:0000256|PROSITE-ProRule:PRU00276" FT BINDING 654 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="1" FT /evidence="ECO:0000256|PIRSR:PIRSR613273-2" FT DISULFID 527..574 FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3" FT DISULFID 549..557 FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3" FT DISULFID 569..654 FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3" FT DISULFID 606..638 FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3" FT DISULFID 681..703 FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3" FT DISULFID 692..714 FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3" FT DISULFID 698..734 FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3" FT DISULFID 727..739 FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3" FT DISULFID 763..800 FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3" FT DISULFID 767..805 FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3" FT DISULFID 778..790 FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3" SQ SEQUENCE 1688 AA; 189868 MW; 48FB8DD4DE0CA4D2 CRC64; MSMPDAGSLK SPAGGQEVEC HRLLSDLPAF AYPSTTLRST TSGHSTGTNS TTVCESPGAR DRTSFACSSS CVSSACSATA SDDDEDERAL ERCLRGTTDD LGESGLRYSL KGPPPELYSA KKDFISKGPL LGRQLEVKKR CEWWCHKYIQ KMSTHWRQNA CLYACCIAFL LGMLIMFHLG LRSAHKGQEE LPQSTHPLAN SPPATPATLH PRRLDNDTST DHEPPDGLDD LDEEEHSAFV MPTKVYNYSL SEADLIYESK RNSDINSFLK ESASAFAMTG TYRNMSNEIW DPHPQYNLNV FGRQLHLVLR QDASFVHNHS MTHIRILKEG EEHPGPETEA EAEQRHLGCF YSGYVEDDPH SMVSVSLCGG MTGYIKTSFG ALLIQPVNRT SSDEVLHRVF RKSQRNARHA VSKFELGLDD FMSKLEQVQE EEQKSKSRKL NRKKRHYADV DNQVYTLEVL IAVDNSMKQF HGEDLQPYIL ILMSIVSSIF ADASIGNSIR ILLVRLISLP NINDQTHSSN EMLKHFCQFI NQSGYERDTA MLITREPICG SVPGKICHML GLAELGTVCS SSSCSIVQDT GLPTAFTMAH ELGHILNMNH DDDDKCMPYV TRQNNNKVLH IMSSVMGIHM HPWSWSKCSR HFVSEFLEKT DKSCLETSVG AHIPYGTERL PGEIYSLDAQ CQLSFGNDFG YCPTDEECKR LWCNRTSGNS NEQCASSNLP WADGTPCGSS GHWCQRGKCV SNKHGYGRQV NGGWGPWTPF TPCSLTCGGG VQESRRECNQ PVPENGGKYC TGSRKKYRSC NTHQCPPGSM DPREQQCYAM NGRNMNIPGV NPDTKWVPKY EKDACKLFCR MDMKVTYFML KSMVTDGTSC AVDSFDKCVN GICRPAGCDN ELNSIAKLDK CGVCEGRNDT CHEVTGNLLV SNLLGLNDGN EPNKTLYYVT RIPKGASNII ITQRGYPDQN FIVLTDDRDN ELLNGKFLKT YPLKFVYAGV TMQYTGSSSV VEQVNTTYSW KLSRDLIVQI ISLDVSPSKR QDTVLLSYSY TIDKPPDYEA EVEIYRWEMQ APSNCDSLCE GRSHRLPACI STTQGVKVAP QFCDKSAMPK IDDRACNTDC RLNLTVTSIS ECSAACGELG TREKTYACVQ TFTNMQRSNI VDMSYCKLKF DVAYHEECRE GCWVLSEWST CSKSCGTGSQ QREAHCYLHN SRVSDDLCNP RTKPHLNTLI GICNTESCPT YTKSPNALAV SNWVIGEWGE CNEWCEKTRS VSCSHPYGIG CGSRKPKDVR KCCHIKYTSD WTDCSVQCGE GVKRKKQSCT RVYKPDVPGT RKRRVYVDES YCISRKVHRP KLRTTTKSCR INCKWNASDW RRCPADCSEE YQTRDVRCES FQGDGVEDKH CDAKKRPSKR RICNNCVRRQ SRVISQCNCE GVEKRRDFCF NSHKGRIACP TRARVERHSC TPPPHCRRRS AIGSSISSRP RGTGVSSSRS LNSIGGSRNR GTPRSCADLK EMHGYNKDGN YQLEVRSRMV HIYCHGMNSR TPQEYVNVDP QENYSIYYEY RTKQTNSCPP ESRGHEYYND QNSGRTHFRK LRLNITDLRI MDNDFKFADS RGLAQKLGSA GDCYNRIGQC PQGDFSINMK DTDFSIRPGT VWRMHGQYSV MKRISEFDTT TQMRRGFCGG YCGGCYIAPD SGLYLDVL //