ID Q8SXB0_DROME Unreviewed; 1688 AA. AC Q8SXB0; Q9VF61; DT 01-JUN-2002, integrated into UniProtKB/TrEMBL. DT 01-JUN-2002, sequence version 1. DT 10-OCT-2018, entry version 160. DE SubName: Full=ADAM metallopeptidase with thrombospondin type 1 motif A, isoform B {ECO:0000313|EMBL:AAS65157.1}; DE EC=3.4.24.- {ECO:0000313|EMBL:AAS65157.1}; DE SubName: Full=GH16393p {ECO:0000313|EMBL:AAM11069.1}; GN Name=AdamTS-A {ECO:0000313|EMBL:AAS65157.1, GN ECO:0000313|FlyBase:FBgn0286071}; GN Synonyms=CT19033 {ECO:0000313|EMBL:AAS65157.1}, Dmel\CG14869 GN {ECO:0000313|EMBL:AAS65157.1}; GN ORFNames=CG14869 {ECO:0000313|EMBL:AAS65157.1, GN ECO:0000313|FlyBase:FBgn0286071}, CG6107 GN {ECO:0000313|EMBL:AAM11069.1}, Dmel_CG14869 GN {ECO:0000313|EMBL:AAS65157.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAM11069.1}; RN [1] {ECO:0000313|EMBL:AAS65157.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAS65157.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AAS65157.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AAS65157.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002). RN [5] {ECO:0000313|EMBL:AAS65157.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AAM11069.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Berkeley {ECO:0000313|EMBL:AAM11069.1}; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., RA Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., RA George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., RA Miranda A., Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., RA Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., RA Celniker S.; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:AAS65157.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [8] {ECO:0000313|EMBL:AAS65157.1} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., RA Yu C., Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:AAS65157.1} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:AAS65157.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [11] {ECO:0000313|EMBL:AAS65157.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [12] {ECO:0000313|EMBL:AAS65157.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109357; RG FlyBase Consortium; RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., RA St Pierre S.E., Gramates L.S., Zhou P., Schroeder A.J., Falls K., RA Strelets V., Russo S.M., Gelbart W.M.; RT "Gene Model Annotations for Drosophila melanogaster: Impact of High- RT Throughput Data."; RL G3 (Bethesda) 5:1721-1736(2015). RN [13] {ECO:0000313|EMBL:AAS65157.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109356; RG FlyBase Consortium; RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., RA St Pierre S.E., Zhou P., Schroeder A.J., Falls K., Emmert D.B., RA Russo S.M., Gelbart W.M.; RT "Gene Model Annotations for Drosophila melanogaster: The Rule- RT Benders."; RL G3 (Bethesda) 5:1737-1749(2015). RN [14] {ECO:0000313|EMBL:AAS65157.1} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY094716; AAM11069.1; -; mRNA. DR EMBL; AE014297; AAS65157.1; -; Genomic_DNA. DR RefSeq; NP_996218.1; NM_206496.2. DR UniGene; Dm.11730; -. DR IntAct; Q8SXB0; 7. DR STRING; 7227.FBpp0082614; -. DR MEROPS; M12.A03; -. DR EnsemblMetazoa; FBtr0083160; FBpp0082614; FBgn0038341. DR GeneID; 41887; -. DR UCSC; CG14869-RB; d. melanogaster. DR CTD; 41887; -. DR FlyBase; FBgn0286071; AdamTS-A. DR eggNOG; KOG3538; Eukaryota. DR eggNOG; ENOG410XPKZ; LUCA. DR GeneTree; ENSGT00900000140774; -. DR OrthoDB; EOG091G00AX; -. DR Reactome; R-DME-5173214; O-glycosylation of TSR domain-containing proteins. DR GenomeRNAi; 41887; -. DR Proteomes; UP000000803; Chromosome 3R. DR Bgee; FBgn0038341; Expressed in 27 organ(s), highest expression level in adult organism. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0007427; P:epithelial cell migration, open tracheal system; IMP:FlyBase. DR GO; GO:0030198; P:extracellular matrix organization; IMP:FlyBase. DR GO; GO:0007436; P:larval salivary gland morphogenesis; IMP:FlyBase. DR GO; GO:0008078; P:mesodermal cell migration; IMP:FlyBase. DR GO; GO:0007280; P:pole cell migration; IMP:FlyBase. DR Gene3D; 2.20.100.10; -; 2. DR Gene3D; 3.40.390.10; -; 1. DR InterPro; IPR010294; ADAM_spacer1. DR InterPro; IPR024079; MetalloPept_cat_dom_sf. DR InterPro; IPR012314; Pept_M12B_GON-ADAMTSs. DR InterPro; IPR001590; Peptidase_M12B. DR InterPro; IPR002870; Peptidase_M12B_N. DR InterPro; IPR000884; TSP1_rpt. DR InterPro; IPR036383; TSP1_rpt_sf. DR Pfam; PF05986; ADAM_spacer1; 1. DR Pfam; PF08685; GON; 1. DR Pfam; PF01562; Pep_M12B_propep; 1. DR Pfam; PF00090; TSP_1; 3. DR SMART; SM00209; TSP1; 3. DR SUPFAM; SSF82895; SSF82895; 3. DR PROSITE; PS50215; ADAM_MEPRO; 1. DR PROSITE; PS51046; GON; 1. DR PROSITE; PS50092; TSP1; 3. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00517240}; KW Hydrolase {ECO:0000313|EMBL:AAS65157.1}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 160 181 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 455 659 Peptidase M12B. {ECO:0000259|PROSITE: FT PS50215}. FT DOMAIN 1492 1688 GON. {ECO:0000259|PROSITE:PS51046}. FT COILED 418 438 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 1688 AA; 189868 MW; 48FB8DD4DE0CA4D2 CRC64; MSMPDAGSLK SPAGGQEVEC HRLLSDLPAF AYPSTTLRST TSGHSTGTNS TTVCESPGAR DRTSFACSSS CVSSACSATA SDDDEDERAL ERCLRGTTDD LGESGLRYSL KGPPPELYSA KKDFISKGPL LGRQLEVKKR CEWWCHKYIQ KMSTHWRQNA CLYACCIAFL LGMLIMFHLG LRSAHKGQEE LPQSTHPLAN SPPATPATLH PRRLDNDTST DHEPPDGLDD LDEEEHSAFV MPTKVYNYSL SEADLIYESK RNSDINSFLK ESASAFAMTG TYRNMSNEIW DPHPQYNLNV FGRQLHLVLR QDASFVHNHS MTHIRILKEG EEHPGPETEA EAEQRHLGCF YSGYVEDDPH SMVSVSLCGG MTGYIKTSFG ALLIQPVNRT SSDEVLHRVF RKSQRNARHA VSKFELGLDD FMSKLEQVQE EEQKSKSRKL NRKKRHYADV DNQVYTLEVL IAVDNSMKQF HGEDLQPYIL ILMSIVSSIF ADASIGNSIR ILLVRLISLP NINDQTHSSN EMLKHFCQFI NQSGYERDTA MLITREPICG SVPGKICHML GLAELGTVCS SSSCSIVQDT GLPTAFTMAH ELGHILNMNH DDDDKCMPYV TRQNNNKVLH IMSSVMGIHM HPWSWSKCSR HFVSEFLEKT DKSCLETSVG AHIPYGTERL PGEIYSLDAQ CQLSFGNDFG YCPTDEECKR LWCNRTSGNS NEQCASSNLP WADGTPCGSS GHWCQRGKCV SNKHGYGRQV NGGWGPWTPF TPCSLTCGGG VQESRRECNQ PVPENGGKYC TGSRKKYRSC NTHQCPPGSM DPREQQCYAM NGRNMNIPGV NPDTKWVPKY EKDACKLFCR MDMKVTYFML KSMVTDGTSC AVDSFDKCVN GICRPAGCDN ELNSIAKLDK CGVCEGRNDT CHEVTGNLLV SNLLGLNDGN EPNKTLYYVT RIPKGASNII ITQRGYPDQN FIVLTDDRDN ELLNGKFLKT YPLKFVYAGV TMQYTGSSSV VEQVNTTYSW KLSRDLIVQI ISLDVSPSKR QDTVLLSYSY TIDKPPDYEA EVEIYRWEMQ APSNCDSLCE GRSHRLPACI STTQGVKVAP QFCDKSAMPK IDDRACNTDC RLNLTVTSIS ECSAACGELG TREKTYACVQ TFTNMQRSNI VDMSYCKLKF DVAYHEECRE GCWVLSEWST CSKSCGTGSQ QREAHCYLHN SRVSDDLCNP RTKPHLNTLI GICNTESCPT YTKSPNALAV SNWVIGEWGE CNEWCEKTRS VSCSHPYGIG CGSRKPKDVR KCCHIKYTSD WTDCSVQCGE GVKRKKQSCT RVYKPDVPGT RKRRVYVDES YCISRKVHRP KLRTTTKSCR INCKWNASDW RRCPADCSEE YQTRDVRCES FQGDGVEDKH CDAKKRPSKR RICNNCVRRQ SRVISQCNCE GVEKRRDFCF NSHKGRIACP TRARVERHSC TPPPHCRRRS AIGSSISSRP RGTGVSSSRS LNSIGGSRNR GTPRSCADLK EMHGYNKDGN YQLEVRSRMV HIYCHGMNSR TPQEYVNVDP QENYSIYYEY RTKQTNSCPP ESRGHEYYND QNSGRTHFRK LRLNITDLRI MDNDFKFADS RGLAQKLGSA GDCYNRIGQC PQGDFSINMK DTDFSIRPGT VWRMHGQYSV MKRISEFDTT TQMRRGFCGG YCGGCYIAPD SGLYLDVL //