ID Q8SXB0_DROME PRELIMINARY; PRT; 1688 AA. AC Q8SXB0; Q9VF61; DT 01-JUN-2002 (TrEMBLrel. 21, Created) DT 01-JUN-2002 (TrEMBLrel. 21, Last sequence update) DT 01-FEB-2005 (TrEMBLrel. 29, Last annotation update) DE GH16393p (CG14869-PB, isoform B). GN ORFNames=CG14869, CG6107; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Berkeley; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., RA Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., RA George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., RA Miranda A., Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., RA Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., RA Celniker S.; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=22426065; PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [4] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=22426070; PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002). RN [5] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083-RESEARCH0083(2002). RN [6] RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., RA Yu C., Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases. CC -!- INTERACTION: CC Q9VJ53:cg15167; NbExp=1; IntAct=EBI-139623, EBI-122209; CC Q9VR24:cg15631; NbExp=1; IntAct=EBI-139623, EBI-98854; CC Q9VSK1:cg32354; NbExp=1; IntAct=EBI-139623, EBI-148683; CC Q9U1K7:cg3939; NbExp=1; IntAct=EBI-139623, EBI-194508; CC Q95TL8:cg9911; NbExp=1; IntAct=EBI-139623, EBI-100765; CC Q9V650:rep1; NbExp=1; IntAct=EBI-139623, EBI-163074; CC Q9XYQ2:unc-119; NbExp=1; IntAct=EBI-139623, EBI-127298; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY094716; AAM11069.1; -. DR EMBL; AE003709; AAS65157.1; -. DR HSSP; P07996; 1LSL. DR IntAct; Q8SXB0; -. DR Ensembl; CG14869; Drosophila melanogaster. DR FlyBase; FBgn0038340; CG6107. DR GO; GO:0031012; C:extracellular matrix; IEA. DR GO; GO:0004222; F:metalloendopeptidase activity; IEA. DR GO; GO:0006508; P:proteolysis and peptidolysis; IEA. DR InterPro; IPR010294; ADAM_spacer1. DR InterPro; IPR001590; Peptidase_M12B. DR InterPro; IPR002870; Peptidase_M12B_N. DR InterPro; IPR006025; Pept_M_Zn_BS. DR InterPro; IPR000884; TSP1. DR Pfam; PF05986; ADAM_spacer1; 1. DR Pfam; PF01562; Pep_M12B_propep; 1. DR Pfam; PF01421; Reprolysin; 1. DR Pfam; PF00090; TSP_1; 2. DR SMART; SM00209; TSP1; 3. DR PROSITE; PS50215; ADAM_MEPRO; 1. DR PROSITE; PS50092; TSP1; 3. DR PROSITE; PS00142; ZINC_PROTEASE; UNKNOWN_1. SQ SEQUENCE 1688 AA; 189866 MW; 48FB8DD4DE0CA4D2 CRC64; MSMPDAGSLK SPAGGQEVEC HRLLSDLPAF AYPSTTLRST TSGHSTGTNS TTVCESPGAR DRTSFACSSS CVSSACSATA SDDDEDERAL ERCLRGTTDD LGESGLRYSL KGPPPELYSA KKDFISKGPL LGRQLEVKKR CEWWCHKYIQ KMSTHWRQNA CLYACCIAFL LGMLIMFHLG LRSAHKGQEE LPQSTHPLAN SPPATPATLH PRRLDNDTST DHEPPDGLDD LDEEEHSAFV MPTKVYNYSL SEADLIYESK RNSDINSFLK ESASAFAMTG TYRNMSNEIW DPHPQYNLNV FGRQLHLVLR QDASFVHNHS MTHIRILKEG EEHPGPETEA EAEQRHLGCF YSGYVEDDPH SMVSVSLCGG MTGYIKTSFG ALLIQPVNRT SSDEVLHRVF RKSQRNARHA VSKFELGLDD FMSKLEQVQE EEQKSKSRKL NRKKRHYADV DNQVYTLEVL IAVDNSMKQF HGEDLQPYIL ILMSIVSSIF ADASIGNSIR ILLVRLISLP NINDQTHSSN EMLKHFCQFI NQSGYERDTA MLITREPICG SVPGKICHML GLAELGTVCS SSSCSIVQDT GLPTAFTMAH ELGHILNMNH DDDDKCMPYV TRQNNNKVLH IMSSVMGIHM HPWSWSKCSR HFVSEFLEKT DKSCLETSVG AHIPYGTERL PGEIYSLDAQ CQLSFGNDFG YCPTDEECKR LWCNRTSGNS NEQCASSNLP WADGTPCGSS GHWCQRGKCV SNKHGYGRQV NGGWGPWTPF TPCSLTCGGG VQESRRECNQ PVPENGGKYC TGSRKKYRSC NTHQCPPGSM DPREQQCYAM NGRNMNIPGV NPDTKWVPKY EKDACKLFCR MDMKVTYFML KSMVTDGTSC AVDSFDKCVN GICRPAGCDN ELNSIAKLDK CGVCEGRNDT CHEVTGNLLV SNLLGLNDGN EPNKTLYYVT RIPKGASNII ITQRGYPDQN FIVLTDDRDN ELLNGKFLKT YPLKFVYAGV TMQYTGSSSV VEQVNTTYSW KLSRDLIVQI ISLDVSPSKR QDTVLLSYSY TIDKPPDYEA EVEIYRWEMQ APSNCDSLCE GRSHRLPACI STTQGVKVAP QFCDKSAMPK IDDRACNTDC RLNLTVTSIS ECSAACGELG TREKTYACVQ TFTNMQRSNI VDMSYCKLKF DVAYHEECRE GCWVLSEWST CSKSCGTGSQ QREAHCYLHN SRVSDDLCNP RTKPHLNTLI GICNTESCPT YTKSPNALAV SNWVIGEWGE CNEWCEKTRS VSCSHPYGIG CGSRKPKDVR KCCHIKYTSD WTDCSVQCGE GVKRKKQSCT RVYKPDVPGT RKRRVYVDES YCISRKVHRP KLRTTTKSCR INCKWNASDW RRCPADCSEE YQTRDVRCES FQGDGVEDKH CDAKKRPSKR RICNNCVRRQ SRVISQCNCE GVEKRRDFCF NSHKGRIACP TRARVERHSC TPPPHCRRRS AIGSSISSRP RGTGVSSSRS LNSIGGSRNR GTPRSCADLK EMHGYNKDGN YQLEVRSRMV HIYCHGMNSR TPQEYVNVDP QENYSIYYEY RTKQTNSCPP ESRGHEYYND QNSGRTHFRK LRLNITDLRI MDNDFKFADS RGLAQKLGSA GDCYNRIGQC PQGDFSINMK DTDFSIRPGT VWRMHGQYSV MKRISEFDTT TQMRRGFCGG YCGGCYIAPD SGLYLDVL //