ID KGUA_FUSNN Reviewed; 185 AA. AC Q8RHI9; DT 02-AUG-2002, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2002, sequence version 1. DT 14-DEC-2011, entry version 59. DE RecName: Full=Guanylate kinase; DE EC=2.7.4.8; DE AltName: Full=GMP kinase; GN Name=gmk; OrderedLocusNames=FN2033; OS Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP OS 101130 / JCM 8532 / LMG 13131). OC Bacteria; Fusobacteria; Fusobacteriales; Fusobacteriaceae; OC Fusobacterium. OX NCBI_TaxID=190304; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131; RX MEDLINE=21886394; PubMed=11889109; RX DOI=10.1128/JB.184.7.2005-2018.2002; RA Kapatral V., Anderson I., Ivanova N., Reznik G., Los T., Lykidis A., RA Bhattacharyya A., Bartman A., Gardner W., Grechkin G., Zhu L., RA Vasieva O., Chu L., Kogan Y., Chaga O., Goltsman E., Bernal A., RA Larsen N., D'Souza M., Walunas T., Pusch G., Haselkorn R., RA Fonstein M., Kyrpides N.C., Overbeek R.; RT "Genome sequence and analysis of the oral bacterium Fusobacterium RT nucleatum strain ATCC 25586."; RL J. Bacteriol. 184:2005-2018(2002). CC -!- FUNCTION: Essential for recycling GMP and indirectly, cGMP (By CC similarity). CC -!- CATALYTIC ACTIVITY: ATP + GMP = ADP + GDP. CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- SIMILARITY: Belongs to the guanylate kinase family. CC -!- SIMILARITY: Contains 1 guanylate kinase-like domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE009951; AAL94118.1; -; Genomic_DNA. DR RefSeq; NP_602819.1; NC_003454.1. DR ProteinModelPortal; Q8RHI9; -. DR GeneID; 992197; -. DR GenomeReviews; AE009951_GR; FN2033. DR KEGG; fnu:FN2033; -. DR NMPDR; fig|190304.1.peg.498; -. DR HOGENOM; HBG671982; -. DR OMA; EWAEFAG; -. DR PhylomeDB; Q8RHI9; -. DR ProtClustDB; PRK00300; -. DR BioCyc; FNUC190304:FN2033-MONOMER; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004385; F:guanylate kinase activity; IEA:EC. DR GO; GO:0006163; P:purine nucleotide metabolic process; IEA:InterPro. DR HAMAP; MF_00328; Guanylate_kinase; 1; -. DR InterPro; IPR008144; Guanylate_kin. DR InterPro; IPR008145; Guanylate_kin/L-typ_Ca_channel. DR InterPro; IPR020590; Guanylate_kinase_CS. DR InterPro; IPR017665; Guanylate_kinase_sub. DR KO; K00942; -. DR Pfam; PF00625; Guanylate_kin; 1. DR SMART; SM00072; GuKc; 1. DR TIGRFAMs; TIGR03263; Guanyl_kin; 1. DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1. DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1. PE 3: Inferred from homology; KW ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; KW Reference proteome; Transferase. FT CHAIN 1 185 Guanylate kinase. FT /FTId=PRO_0000170540. FT DOMAIN 4 181 Guanylate kinase-like. FT NP_BIND 11 18 ATP (By similarity). SQ SEQUENCE 185 AA; 21025 MW; 988EF86443662B96 CRC64; MSLGALYVVS GPSGAGKSTV CKLVRERLGI NLSISATSRK PRNGEQEGVD YFFITAEEFE RKIKNDDFLE YANVHGNYYG TLKSEVEERL KRGEKVLLEI DVQGGVQVKN KFPEANLIFF KTANKEELEK RLRGRNTDSE EVIQARLKNS LKELEYESKY DRVIINNEIE QACNDLISII ENGVK //