ID   RLMN_THETN              Reviewed;         342 AA.
AC   Q8R9T4;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   22-FEB-2012, entry version 65.
DE   RecName: Full=Ribosomal RNA large subunit methyltransferase N;
DE            EC=2.1.1.192;
DE   AltName: Full=23S rRNA (adenine(2503)-C(2))-methyltransferase;
DE   AltName: Full=23S rRNA m2A2503 methyltransferase;
GN   Name=rlmN; OrderedLocusNames=TTE1502;
OS   Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC
OS   100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Caldanaerobacter.
OX   NCBI_TaxID=273068;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15242 / JCM 11007 / NBRC 100824 / MB4;
RX   MEDLINE=21992816; PubMed=11997336; DOI=10.1101/gr.219302;
RA   Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J.,
RA   Chen Y., Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L.,
RA   Tan H., Chen R., Wang J., Yu J., Yang H.;
RT   "A complete sequence of the T. tengcongensis genome.";
RL   Genome Res. 12:689-700(2002).
CC   -!- FUNCTION: Specifically methylates position 2 of adenine 2503 in
CC       23S rRNA (By similarity).
CC   -!- CATALYTIC ACTIVITY: 2 S-adenosyl-L-methionine + adenine(2503) in
CC       23S rRNA = S-adenosyl-L-homocysteine + L-methionine + 5'-
CC       deoxyadenosine + 2-methyladenine(2503) in 23S rRNA.
CC   -!- COFACTOR: Binds 1 4Fe-4S cluster. The cluster is coordinated with
CC       3 cysteines and an exchangeable S-adenosyl-L-methionine
CC       (Potential).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the radical SAM superfamily. RlmN family.
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DR   EMBL; AE008691; AAM24720.1; -; Genomic_DNA.
DR   RefSeq; NP_623116.1; NC_003869.1.
DR   ProteinModelPortal; Q8R9T4; -.
DR   GeneID; 995686; -.
DR   GenomeReviews; AE008691_GR; TTE1502.
DR   KEGG; tte:TTE1502; -.
DR   PATRIC; 23897712; VBITheTen82880_1509.
DR   eggNOG; COG0820; -.
DR   HOGENOM; HBG335345; -.
DR   KO; K06941; -.
DR   OMA; RLTVCVS; -.
DR   ProtClustDB; PRK14454; -.
DR   BioCyc; TTEN273068:TTE1502-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0070040; F:rRNA (adenine-C2-)-methyltransferase activity; IEA:EC.
DR   HAMAP; MF_01849; 23SrRNA_methyltr_N; 1; -.
DR   InterPro; IPR006638; Elp3/MiaB/NifB.
DR   InterPro; IPR004383; rRNA_lsu_MTrfase_RlmN.
DR   InterPro; IPR007197; rSAM.
DR   InterPro; IPR023404; rSAM_horseshoe.
DR   Gene3D; G3DSA:3.80.30.20; G3DSA:3.80.30.20; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   PIRSF; PIRSF006004; CHP00048; 1.
DR   SMART; SM00729; Elp3; 1.
DR   TIGRFAMs; TIGR00048; TIGR00048; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Complete proteome; Cytoplasm; Iron; Iron-sulfur;
KW   Metal-binding; Methyltransferase; rRNA processing;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    342       Ribosomal RNA large subunit
FT                                methyltransferase N.
FT                                /FTId=PRO_0000350496.
FT   METAL       111    111       Iron-sulfur (4Fe-4S-S-AdoMet)
FT                                (Potential).
FT   METAL       115    115       Iron-sulfur (4Fe-4S-S-AdoMet)
FT                                (Potential).
FT   METAL       118    118       Iron-sulfur (4Fe-4S-S-AdoMet)
FT                                (Potential).
SQ   SEQUENCE   342 AA;  39453 MW;  AFBC048AEDB24289 CRC64;
     MYNLKDMTLE EMEEFFVNLG ESKFRAKQLY KWIYDKRVTD FDLMTDISKN LRAKLKEIAY
     ISELKIIERR VSQIDDTVKY LFLLEDKNII EGVAIKYKFG NTACVSTQVG CNMKCKFCAS
     AIGGKVRDLK ASEMVDQVMA IDSDYGKISN IVLMGSGEPF DNYDEVMKFI KIVNNPYGLK
     IGKRHITIST VGIVPKIYQF ADEELQVNLS ISLHAPNNEL RNELMPINRA YPLEELMKAC
     RYYIEKTNRR ITFEYALIDG VNDKKEHAYQ LVDLLKGMLC HVNLIPINYV KEIGFRKSNN
     EKVMMFKKII ENAGITCTVR RELGSDIEAA CGQLRRKYLK EG
//