ID RLMN_THETN Reviewed; 342 AA. AC Q8R9T4; DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2002, sequence version 1. DT 08-FEB-2011, entry version 56. DE RecName: Full=Ribosomal RNA large subunit methyltransferase N; DE EC=2.1.1.192; DE AltName: Full=23S rRNA m2A2503 methyltransferase; GN Name=rlmN; OrderedLocusNames=TTE1502; OS Thermoanaerobacter tengcongensis. OC Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales; OC Thermoanaerobacteraceae; Caldanaerobacter. OX NCBI_TaxID=119072; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DSM 15242 / JCM 11007 / NBRC 100824 / MB4; RX MEDLINE=21992816; PubMed=11997336; DOI=10.1101/gr.219302; RA Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., RA Chen Y., Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., RA Tan H., Chen R., Wang J., Yu J., Yang H.; RT "A complete sequence of the T. tengcongensis genome."; RL Genome Res. 12:689-700(2002). CC -!- FUNCTION: Specifically methylates position 2 of adenine 2503 in CC 23S rRNA (By similarity). CC -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + adenine(2503) in 23S CC rRNA = S-adenosyl-L-homocysteine + 2-methyladenine(2503) in 23S CC rRNA. CC -!- COFACTOR: Binds 1 4Fe-4S cluster. The cluster is coordinated with CC 3 cysteines and an exchangeable S-adenosyl-L-methionine CC (Potential). CC -!- SUBCELLULAR LOCATION: Cytoplasm (Potential). CC -!- SIMILARITY: Belongs to the radical SAM superfamily. RlmN family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE008691; AAM24720.1; -; Genomic_DNA. DR RefSeq; NP_623116.1; NC_003869.1. DR ProteinModelPortal; Q8R9T4; -. DR GeneID; 995686; -. DR GenomeReviews; AE008691_GR; TTE1502. DR KEGG; tte:TTE1502; -. DR NMPDR; fig|273068.3.peg.1463; -. DR HOGENOM; HBG335345; -. DR OMA; TFCSTAQ; -. DR ProtClustDB; PRK14454; -. DR BioCyc; TTEN273068:TTE1502-MONOMER; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro. DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. DR HAMAP; MF_01849; 23SrRNA_methyltr_N; 1; -. DR InterPro; IPR006638; Elp3/MiaB/NifB. DR InterPro; IPR007197; Radical_SAM. DR InterPro; IPR004383; rRNA_lsu_MTrfase_RlmN. DR Pfam; PF04055; Radical_SAM; 1. DR PIRSF; PIRSF006004; CHP00048; 1. DR SMART; SM00729; Elp3; 1. DR TIGRFAMs; TIGR00048; CHP48; 1. PE 3: Inferred from homology; KW 4Fe-4S; Complete proteome; Cytoplasm; Iron; Iron-sulfur; KW Metal-binding; Methyltransferase; rRNA processing; KW S-adenosyl-L-methionine; Transferase. FT CHAIN 1 342 Ribosomal RNA large subunit FT methyltransferase N. FT /FTId=PRO_0000350496. FT METAL 111 111 Iron-sulfur (4Fe-4S-S-AdoMet) FT (Potential). FT METAL 115 115 Iron-sulfur (4Fe-4S-S-AdoMet) FT (Potential). FT METAL 118 118 Iron-sulfur (4Fe-4S-S-AdoMet) FT (Potential). SQ SEQUENCE 342 AA; 39453 MW; AFBC048AEDB24289 CRC64; MYNLKDMTLE EMEEFFVNLG ESKFRAKQLY KWIYDKRVTD FDLMTDISKN LRAKLKEIAY ISELKIIERR VSQIDDTVKY LFLLEDKNII EGVAIKYKFG NTACVSTQVG CNMKCKFCAS AIGGKVRDLK ASEMVDQVMA IDSDYGKISN IVLMGSGEPF DNYDEVMKFI KIVNNPYGLK IGKRHITIST VGIVPKIYQF ADEELQVNLS ISLHAPNNEL RNELMPINRA YPLEELMKAC RYYIEKTNRR ITFEYALIDG VNDKKEHAYQ LVDLLKGMLC HVNLIPINYV KEIGFRKSNN EKVMMFKKII ENAGITCTVR RELGSDIEAA CGQLRRKYLK EG //