ID Q8R3X9_MOUSE Unreviewed; 219 AA. AC Q8R3X9; DT 01-JUN-2002, integrated into UniProtKB/TrEMBL. DT 01-JUN-2002, sequence version 1. DT 04-FEB-2015, entry version 70. DE SubName: Full=Pdgfb protein {ECO:0000313|EMBL:AAH23427.1}; DE Flags: Fragment; GN Name=Pdgfb {ECO:0000313|EMBL:AAH23427.1, ECO:0000313|MGI:MGI:97528}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH23427.1}; RN [1] {ECO:0000313|EMBL:AAH23427.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N-3 {ECO:0000313|EMBL:AAH23427.1}; RC TISSUE=Mammary tumor. MMTV-LTR/INT3 model. 5 month old mouse. Taken by RC biopsy. {ECO:0000313|EMBL:AAH23427.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family. CC {ECO:0000256|RuleBase:RU003818}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC023427; AAH23427.1; -; mRNA. DR UniGene; Mm.144089; -. DR ProteinModelPortal; Q8R3X9; -. DR MGI; MGI:97528; Pdgfb. DR HOVERGEN; HBG053546; -. DR Genevestigator; Q8R3X9; -. DR GO; GO:0009986; C:cell surface; ISO:MGI. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0016020; C:membrane; IEA:InterPro. DR GO; GO:0042056; F:chemoattractant activity; ISO:MGI. DR GO; GO:0005518; F:collagen binding; ISO:MGI. DR GO; GO:0008083; F:growth factor activity; ISO:MGI. DR GO; GO:0042802; F:identical protein binding; ISO:MGI. DR GO; GO:0048407; F:platelet-derived growth factor binding; ISO:MGI. DR GO; GO:0005161; F:platelet-derived growth factor receptor binding; ISO:MGI. DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI. DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI. DR GO; GO:0016176; F:superoxide-generating NADPH oxidase activator activity; ISO:MGI. DR GO; GO:0030036; P:actin cytoskeleton organization; IDA:MGI. DR GO; GO:0032147; P:activation of protein kinase activity; ISO:MGI. DR GO; GO:0032148; P:activation of protein kinase B activity; ISO:MGI. DR GO; GO:0007596; P:blood coagulation; IBA:GO_Central. DR GO; GO:0048514; P:blood vessel morphogenesis; IDA:MGI. DR GO; GO:0060445; P:branching involved in salivary gland morphogenesis; IMP:MGI. DR GO; GO:0060326; P:cell chemotaxis; ISO:MGI. DR GO; GO:0030031; P:cell projection assembly; IDA:MGI. DR GO; GO:0071363; P:cellular response to growth factor stimulus; ISO:MGI. DR GO; GO:0060664; P:epithelial cell proliferation involved in salivary gland morphogenesis; IMP:MGI. DR GO; GO:0002548; P:monocyte chemotaxis; ISO:MGI. DR GO; GO:0030336; P:negative regulation of cell migration; IGI:MGI. DR GO; GO:0010512; P:negative regulation of phosphatidylinositol biosynthetic process; ISO:MGI. DR GO; GO:0010544; P:negative regulation of platelet activation; ISO:MGI. DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI. DR GO; GO:0018105; P:peptidyl-serine phosphorylation; ISO:MGI. DR GO; GO:0018108; P:peptidyl-tyrosine phosphorylation; ISO:MGI. DR GO; GO:0048008; P:platelet-derived growth factor receptor signaling pathway; ISO:MGI. DR GO; GO:0050918; P:positive chemotaxis; ISO:MGI. DR GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; ISO:MGI. DR GO; GO:0090280; P:positive regulation of calcium ion import; ISO:MGI. DR GO; GO:0030335; P:positive regulation of cell migration; IGI:MGI. DR GO; GO:0008284; P:positive regulation of cell proliferation; ISO:MGI. DR GO; GO:0050921; P:positive regulation of chemotaxis; ISO:MGI. DR GO; GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; ISO:MGI. DR GO; GO:2000573; P:positive regulation of DNA biosynthetic process; ISO:MGI. DR GO; GO:0045740; P:positive regulation of DNA replication; ISO:MGI. DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IGI:MGI. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:MGI. DR GO; GO:0045743; P:positive regulation of fibroblast growth factor receptor signaling pathway; IDA:MGI. DR GO; GO:0048146; P:positive regulation of fibroblast proliferation; ISO:MGI. DR GO; GO:0072126; P:positive regulation of glomerular mesangial cell proliferation; ISO:MGI. DR GO; GO:1900127; P:positive regulation of hyaluronan biosynthetic process; ISO:MGI. DR GO; GO:0043406; P:positive regulation of MAP kinase activity; ISO:MGI. DR GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:MGI. DR GO; GO:2000591; P:positive regulation of metanephric mesenchymal cell migration; ISO:MGI. DR GO; GO:0035793; P:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; ISO:MGI. DR GO; GO:0045840; P:positive regulation of mitosis; ISO:MGI. DR GO; GO:0045977; P:positive regulation of mitotic cell cycle, embryonic; IGI:MGI. DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISO:MGI. DR GO; GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; ISO:MGI. DR GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IGI:MGI. DR GO; GO:0031954; P:positive regulation of protein autophosphorylation; ISO:MGI. DR GO; GO:0061098; P:positive regulation of protein tyrosine kinase activity; ISO:MGI. DR GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; ISO:MGI. DR GO; GO:0014911; P:positive regulation of smooth muscle cell migration; ISO:MGI. DR GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; ISO:MGI. DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI. DR GO; GO:0006468; P:protein phosphorylation; ISO:MGI. DR GO; GO:0072593; P:reactive oxygen species metabolic process; ISO:MGI. DR GO; GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation; IDA:MGI. DR GO; GO:0009611; P:response to wounding; ISO:MGI. DR GO; GO:0006929; P:substrate-dependent cell migration; IDA:MGI. DR Gene3D; 2.10.90.10; -; 1. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR023581; PD_growth_factor_CS. DR InterPro; IPR000072; PDGF/VEGF_dom. DR InterPro; IPR006782; PDGF_N. DR Pfam; PF00341; PDGF; 1. DR Pfam; PF04692; PDGF_N; 1. DR SMART; SM00141; PDGF; 1. DR SUPFAM; SSF57501; SSF57501; 1. DR PROSITE; PS00249; PDGF_1; 1. DR PROSITE; PS50278; PDGF_2; 1. PE 2: Evidence at transcript level; KW Growth factor {ECO:0000256|RuleBase:RU003818, KW ECO:0000256|SAAS:SAAS00011360}; KW Mitogen {ECO:0000256|RuleBase:RU003819}. FT NON_TER 1 1 {ECO:0000313|EMBL:AAH23427.1}. SQ SEQUENCE 219 AA; 24889 MW; 71942618732CB32E CRC64; RTRGEELYEM LSDHSIRSFD DLQRLLHRDS VDEDGAELDL NMTRAHSGVE LESSSRGRRS LGSLAAAEPA VIAECKTRTE VFQISRNLID RTNANFLVWP PCVEVQRCSG CCNNRNVQCR ASQVQMRPVQ VRKIEIVRKK PIFKKATVTL EDHLACKCET IVTPRPVTRS PGTSREQRAK TPQARVTIRT VRIRRPPKGK HRKFKHTHDK AALKETLGA //