ID Q8R3X9_MOUSE Unreviewed; 219 AA. AC Q8R3X9; DT 01-JUN-2002, integrated into UniProtKB/TrEMBL. DT 01-JUN-2002, sequence version 1. DT 26-NOV-2014, entry version 68. DE SubName: Full=Pdgfb protein {ECO:0000313|EMBL:AAH23427.1}; DE Flags: Fragment; GN Name=Pdgfb {ECO:0000313|EMBL:AAH23427.1, ECO:0000313|MGI:MGI:97528}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH23427.1}; RN [1] {ECO:0000313|EMBL:AAH23427.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N-3 {ECO:0000313|EMBL:AAH23427.1}; RC TISSUE=Mammary tumor. MMTV-LTR/INT3 model. 5 month old mouse. Taken by RC biopsy. {ECO:0000313|EMBL:AAH23427.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family. CC {ECO:0000256|RuleBase:RU003818}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC023427; AAH23427.1; -; mRNA. DR UniGene; Mm.144089; -. DR ProteinModelPortal; Q8R3X9; -. DR MGI; MGI:97528; Pdgfb. DR HOVERGEN; HBG053546; -. DR Genevestigator; Q8R3X9; -. DR GO; GO:0005615; C:extracellular space; IBA:RefGenome. DR GO; GO:0016020; C:membrane; IEA:InterPro. DR GO; GO:0005161; F:platelet-derived growth factor receptor binding; IBA:RefGenome. DR GO; GO:0030036; P:actin cytoskeleton organization; IDA:MGI. DR GO; GO:0007596; P:blood coagulation; IBA:RefGenome. DR GO; GO:0048514; P:blood vessel morphogenesis; IDA:MGI. DR GO; GO:0060445; P:branching involved in salivary gland morphogenesis; IMP:MGI. DR GO; GO:0030031; P:cell projection assembly; IDA:MGI. DR GO; GO:0060664; P:epithelial cell proliferation involved in salivary gland morphogenesis; IMP:MGI. DR GO; GO:0030336; P:negative regulation of cell migration; IGI:MGI. DR GO; GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IBA:RefGenome. DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW. DR GO; GO:0030335; P:positive regulation of cell migration; IGI:MGI. DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IGI:MGI. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:RefGenome. DR GO; GO:0045743; P:positive regulation of fibroblast growth factor receptor signaling pathway; IDA:MGI. DR GO; GO:0043406; P:positive regulation of MAP kinase activity; IBA:RefGenome. DR GO; GO:0045977; P:positive regulation of mitotic cell cycle, embryonic; IGI:MGI. DR GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IGI:MGI. DR GO; GO:0031954; P:positive regulation of protein autophosphorylation; IBA:RefGenome. DR GO; GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation; IDA:MGI. DR GO; GO:0006929; P:substrate-dependent cell migration; IDA:MGI. DR Gene3D; 2.10.90.10; -; 1. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR023581; PD_growth_factor_CS. DR InterPro; IPR000072; PDGF/VEGF_dom. DR InterPro; IPR006782; PDGF_N. DR Pfam; PF00341; PDGF; 1. DR Pfam; PF04692; PDGF_N; 1. DR SMART; SM00141; PDGF; 1. DR SUPFAM; SSF57501; SSF57501; 1. DR PROSITE; PS00249; PDGF_1; 1. DR PROSITE; PS50278; PDGF_2; 1. PE 2: Evidence at transcript level; KW Growth factor {ECO:0000256|RuleBase:RU003818, KW ECO:0000256|SAAS:SAAS00011360}; KW Mitogen {ECO:0000256|RuleBase:RU003819}. FT NON_TER 1 1 {ECO:0000313|EMBL:AAH23427.1}. SQ SEQUENCE 219 AA; 24889 MW; 71942618732CB32E CRC64; RTRGEELYEM LSDHSIRSFD DLQRLLHRDS VDEDGAELDL NMTRAHSGVE LESSSRGRRS LGSLAAAEPA VIAECKTRTE VFQISRNLID RTNANFLVWP PCVEVQRCSG CCNNRNVQCR ASQVQMRPVQ VRKIEIVRKK PIFKKATVTL EDHLACKCET IVTPRPVTRS PGTSREQRAK TPQARVTIRT VRIRRPPKGK HRKFKHTHDK AALKETLGA //