ID NAR3_MOUSE Reviewed; 371 AA. AC Q8R2G4; B2RUC2; O54738; Q8R2F9; Q8R2G0; Q8R2G1; Q8R2G2; Q8R2G3; DT 13-AUG-2002, integrated into UniProtKB/Swiss-Prot. DT 20-JAN-2009, sequence version 2. DT 08-MAR-2011, entry version 77. DE RecName: Full=Ecto-ADP-ribosyltransferase 3; DE EC=2.4.2.31; DE AltName: Full=Mono(ADP-ribosyl)transferase 3; DE AltName: Full=NAD(P)(+)--arginine ADP-ribosyltransferase 3; DE Flags: Precursor; GN Name=Art3; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 5). RX MEDLINE=22065832; PubMed=12070318; DOI=10.1110/ps.0200602; RA Glowacki G., Braren R., Firner K., Nissen M., Kuehl M., Reche P., RA Bazan J.F., Cetkovic-Cvrlje M., Leiter E., Haag F., Koch-Nolte F.; RT "The family of toxin-related ecto-ADP-ribosyltransferases in humans RT and the mouse."; RL Protein Sci. 11:1657-1670(2002). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 8). RC TISSUE=Testis; RA Koch-Nolte F., Firner K., Haag F., Khl M., Thiele H.G.; RT "Molecular cloning of two ecto-mono(ADP-ribosyl)transferases operating RT in murine testis."; RL Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7). RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- CATALYTIC ACTIVITY: NAD(+) + protein-L-arginine = nicotinamide + CC N(omega)-(ADP-D-ribosyl)-protein-L-arginine. CC -!- CATALYTIC ACTIVITY: NADP(+) + protein-L-arginine = nicotinamide + CC N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine. CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor (By CC similarity). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=8; CC IsoId=Q8R2G4-5; Sequence=Displayed; CC Name=5; CC IsoId=Q8R2G4-7; Sequence=VSP_036193; CC Name=7; CC IsoId=Q8R2G4-8; Sequence=VSP_036199; CC Note=No experimental confirmation available; CC -!- SIMILARITY: Belongs to the Arg-specific ADP-ribosyltransferase CC family. CC -!- SEQUENCE CAUTION: CC Sequence=CAC84526.1; Type=Miscellaneous discrepancy; Note=3'extension leads to out-of-frame translation; CC Sequence=CAC84539.1; Type=Erroneous gene model prediction; CC Sequence=CAC84540.1; Type=Miscellaneous discrepancy; Note=3'extension leads to out-of-frame translation; CC Sequence=CAC84541.1; Type=Miscellaneous discrepancy; Note=3'extension leads to out-of-frame translation; CC Sequence=CAC84543.1; Type=Miscellaneous discrepancy; Note=3'extension leads to out-of-frame translation; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ311768; CAC84539.1; ALT_SEQ; Genomic_DNA. DR EMBL; AJ311769; CAC84526.1; ALT_SEQ; mRNA. DR EMBL; AJ311770; CAC84540.1; ALT_SEQ; mRNA. DR EMBL; AJ311771; CAC84541.1; ALT_SEQ; mRNA. DR EMBL; AJ311772; CAC84542.1; -; mRNA. DR EMBL; AJ311773; CAC84543.1; ALT_SEQ; mRNA. DR EMBL; Y08027; CAA69284.1; -; Genomic_DNA. DR EMBL; BC141069; AAI41070.1; -; mRNA. DR IPI; IPI00229197; -. DR IPI; IPI00880925; -. DR IPI; IPI00919012; -. DR RefSeq; NP_859417.2; NM_181728.2. DR UniGene; Mm.263514; -. DR ProteinModelPortal; Q8R2G4; -. DR SMR; Q8R2G4; 27-258. DR STRING; Q8R2G4; -. DR PRIDE; Q8R2G4; -. DR Ensembl; ENSMUST00000038654; ENSMUSP00000038935; ENSMUSG00000034842. DR Ensembl; ENSMUST00000113083; ENSMUSP00000108706; ENSMUSG00000034842. DR Ensembl; ENSMUST00000113087; ENSMUSP00000108710; ENSMUSG00000034842. DR Ensembl; ENSMUST00000121096; ENSMUSP00000113510; ENSMUSG00000034842. DR GeneID; 109979; -. DR KEGG; mmu:109979; -. DR UCSC; uc008ycy.1; mouse. DR UCSC; uc008ydf.1; mouse. DR CTD; 109979; -. DR MGI; MGI:1202729; Art3. DR eggNOG; roNOG15561; -. DR HOVERGEN; HBG006445; -. DR InParanoid; Q8R2G4; -. DR OrthoDB; EOG41JZCQ; -. DR BRENDA; 2.4.2.31; 244. DR NextBio; 363113; -. DR ArrayExpress; Q8R2G4; -. DR Bgee; Q8R2G4; -. DR CleanEx; MM_ART3; -. DR Genevestigator; Q8R2G4; -. DR GermOnline; ENSMUSG00000034842; Mus musculus. DR GO; GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0003956; F:NAD(P)+-protein-arginine ADP-ribosyltransferase activity; IEA:EC. DR GO; GO:0006471; P:protein ADP-ribosylation; IEA:InterPro. DR InterPro; IPR000768; ART. DR PANTHER; PTHR10339; ART; 1. DR Pfam; PF01129; ART; 1. DR PRINTS; PR00970; RIBTRNSFRASE. PE 2: Evidence at transcript level; KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein; KW Glycosyltransferase; GPI-anchor; Lipoprotein; Membrane; NAD; NADP; KW Signal; Transferase. FT SIGNAL 1 26 Potential. FT CHAIN 27 345 Ecto-ADP-ribosyltransferase 3. FT /FTId=PRO_0000019327. FT PROPEP 346 371 Removed in mature form (By similarity). FT /FTId=PRO_0000019328. FT ACT_SITE 228 228 By similarity. FT BINDING 101 101 NAD (By similarity). FT BINDING 182 182 NAD (By similarity). FT LIPID 345 345 GPI-anchor amidated serine (By FT similarity). FT DISULFID 43 255 By similarity. FT VAR_SEQ 271 291 Missing (in isoform 5). FT /FTId=VSP_036193. FT VAR_SEQ 321 331 DRSRGKANNPT -> A (in isoform 7). FT /FTId=VSP_036199. FT CONFLICT 11 15 TLLAA -> AAGS (in Ref. 2; CAA69284). FT CONFLICT 348 348 Missing (in Ref. 3; AAI41070). SQ SEQUENCE 371 AA; 42015 MW; 52F1B373A928182B CRC64; MKMGHFEMVT TLLAAAVLMD IFQVKAEVLD MAENAFDDEY LKCKSRMESK YIPQMKREEW ANDALLRMVW DNAEIQWEAR KAQLFLPRNF KDTYGIALTA YVNEAQEQTS FYHTFSSAVK MAGLSRRRYI YNFPFKAFHF YLVRALQLLR RPCEKSYKTV VYSTSPDISF TFGEQNQARL GNFTLAYSAK PETADNQRVL TIQTCFGVAV GKFLNKEDDS VVLIPLSEVF QVSRKGTSND LVLQSINSTC SYYECAFLGG LKTENCIANA EYIDPRYLYN PDMDNQKLED SGRNNLDPDR MPEIKVLQTE ENPLLPDEKP DRSRGKANNP TPGLVPGPKS HPSASSGNTL LPSVMASTIL LVASAVNFIE L //