ID NAR3_MOUSE Reviewed; 371 AA. AC Q8R2G4; B2RUC2; O54738; Q8R2F9; Q8R2G0; Q8R2G1; Q8R2G2; Q8R2G3; DT 13-AUG-2002, integrated into UniProtKB/Swiss-Prot. DT 20-JAN-2009, sequence version 2. DT 24-MAR-2009, entry version 60. DE RecName: Full=Ecto-ADP-ribosyltransferase 3; DE EC=2.4.2.31; DE AltName: Full=NAD(P)(+)--arginine ADP-ribosyltransferase 3; DE AltName: Full=Mono(ADP-ribosyl)transferase 3; DE Flags: Precursor; GN Name=Art3; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 2; 3; 4; 5 AND 6). RX MEDLINE=22065832; PubMed=12070318; DOI=10.1110/ps.0200602; RA Glowacki G., Braren R., Firner K., Nissen M., Kuehl M., Reche P., RA Bazan J.F., Cetkovic-Cvrlje M., Leiter E., Haag F., Koch-Nolte F.; RT "The family of toxin-related ecto-ADP-ribosyltransferases in humans RT and the mouse."; RL Protein Sci. 11:1657-1670(2002). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 8). RC TISSUE=Testis; RA Koch-Nolte F., Firner K., Haag F., Khl M., Thiele H.G.; RT "Molecular cloning of two ecto-mono(ADP-ribosyl)transferases operating RT in murine testis."; RL Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7). RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- CATALYTIC ACTIVITY: NAD(+) + protein-L-arginine = nicotinamide + CC N(omega)-(ADP-D-ribosyl)-protein-L-arginine. CC -!- CATALYTIC ACTIVITY: NADP(+) + protein-L-arginine = nicotinamide + CC N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine. CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor (By CC similarity). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=7; CC Name=8; CC IsoId=Q8R2G4-5; Sequence=Displayed; CC Name=2; CC IsoId=Q8R2G4-2; Sequence=VSP_036195; CC Name=3; CC IsoId=Q8R2G4-3; Sequence=VSP_036196; CC Name=4; CC IsoId=Q8R2G4-4; Sequence=VSP_036197; CC Name=6; CC IsoId=Q8R2G4-6; Sequence=VSP_036198; CC Note=Non-canonical intron-exon junction (CA/AG). No experimental CC confirmation available; CC Name=5; CC IsoId=Q8R2G4-7; Sequence=VSP_036193; CC Name=7; CC IsoId=Q8R2G4-8; Sequence=VSP_036199; CC Note=No experimental confirmation available; CC -!- PTM: Contains two disulfide bonds (By similarity). CC -!- SIMILARITY: Belongs to the Arg-specific ADP-ribosyltransferase CC family. CC -!- SEQUENCE CAUTION: CC Sequence=CAC84539.1; Type=Erroneous gene model prediction; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ311768; CAC84539.1; ALT_SEQ; Genomic_DNA. DR EMBL; AJ311769; CAC84526.1; -; mRNA. DR EMBL; AJ311770; CAC84540.1; -; mRNA. DR EMBL; AJ311771; CAC84541.1; -; mRNA. DR EMBL; AJ311772; CAC84542.1; -; mRNA. DR EMBL; AJ311773; CAC84543.1; -; mRNA. DR EMBL; Y08027; CAA69284.1; -; Genomic_DNA. DR EMBL; BC141069; AAI41070.1; -; mRNA. DR IPI; IPI00153579; -. DR IPI; IPI00229194; -. DR IPI; IPI00229195; -. DR IPI; IPI00229196; -. DR IPI; IPI00229197; -. DR IPI; IPI00229198; -. DR IPI; IPI00880925; -. DR IPI; IPI00919012; -. DR RefSeq; NP_859417.2; -. DR UniGene; Mm.263514; -. DR HSSP; P20974; 1GXY. DR PRIDE; Q8R2G4; -. DR Ensembl; ENSMUSG00000034842; Mus musculus. DR GeneID; 109979; -. DR KEGG; mmu:109979; -. DR MGI; MGI:1202729; Art3. DR HOGENOM; Q8R2G4; -. DR HOVERGEN; Q8R2G4; -. DR BRENDA; 2.4.2.31; 244. DR NextBio; 363113; -. DR Bgee; Q8R2G4; -. DR CleanEx; MM_ART3; -. DR GermOnline; ENSMUSG00000034842; Mus musculus. DR GO; GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0003956; F:NAD(P)+-protein-arginine ADP-ribosyltransfe...; IEA:InterPro. DR GO; GO:0006471; P:protein amino acid ADP-ribosylation; IEA:InterPro. DR InterPro; IPR000768; ART. DR PANTHER; PTHR10339; ART; 1. DR Pfam; PF01129; ART; 1. DR PRINTS; PR00970; RIBTRNSFRASE. PE 2: Evidence at transcript level; KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein; KW Glycosyltransferase; GPI-anchor; Lipoprotein; Membrane; NAD; NADP; KW Signal; Transferase. FT SIGNAL 1 26 Potential. FT CHAIN 27 345 Ecto-ADP-ribosyltransferase 3. FT /FTId=PRO_0000019327. FT PROPEP 346 371 Removed in mature form (By similarity). FT /FTId=PRO_0000019328. FT ACT_SITE 228 228 By similarity. FT LIPID 345 345 GPI-anchor amidated serine (By FT similarity). FT VAR_SEQ 271 291 Missing (in isoform 5). FT /FTId=VSP_036193. FT VAR_SEQ 282 371 DMDNQKLEDSGRNNLDPDRMPEIKVLQTEENPLLPDEKPDR FT SRGKANNPTPGLVPGPKSHPSASSGNTLLPSVMASTILLVA FT SAVNFIEL -> GEYTLLQTTQIWTIRSLKTLVGTTLTLTE FT CQKLKCYKQRKILSCRMKSLLQVWFQVRNPIPLHPLAIRSF FT HQSWHPPFYSLLLL (in isoform 2). FT /FTId=VSP_036195. FT VAR_SEQ 282 371 DMDNQKLEDSGRNNLDPDRMPEIKVLQTEENPLLPDEKPDR FT SRGKANNPTPGLVPGPKSHPSASSGNTLLPSVMASTILLVA FT SAVNFIEL -> GEYTLLQTTQIWTIRSLKTLVPGIKPWAP FT CKLVGTTLTLTECQKLKCYKQRKILSCRMKSLLQVWFQVRN FT PIPLHPLAIRSFHQSWHPPFYSLLLL (in isoform FT 3). FT /FTId=VSP_036196. FT VAR_SEQ 282 371 DMDNQKLEDSGRNNLDPDRMPEIKVLQTEENPLLPDEKPDR FT SRGKANNPTPGLVPGPKSHPSASSGNTLLPSVMASTILLVA FT SAVNFIEL -> GEYTLLQTTQIWTIRSLKTLVGTTLTLTE FT CQKLKCYKQRKILSCRMKSLTEVEERPTILLQVWFQVRNPI FT PLHPLAIRSFHQSWHPPFYSLLLL (in isoform 4). FT /FTId=VSP_036197. FT VAR_SEQ 282 371 DMDNQKLEDSGRNNLDPDRMPEIKVLQTEENPLLPDEKPDR FT SRGKANNPTPGLVPGPKSHPSASSGNTLLPSVMASTILLVA FT SAVNFIEL -> GEYTLLQTTQIWTIRSLKTLVGTTLTLTE FT CQKLKCYKQRKILSCRMKSLTEVEERPTILVRNTSFSLKNA FT LKYKTVKLILFFIKSSRSGSRSEIPSLCILWQYAPSISHGI FT HHFTRCFCCKLHRAIA (in isoform 6). FT /FTId=VSP_036198. FT VAR_SEQ 321 331 DRSRGKANNPT -> A (in isoform 7). FT /FTId=VSP_036199. FT CONFLICT 11 15 TLLAA -> AAGS (in Ref. 2; CAA69284). FT CONFLICT 348 348 Missing (in Ref. 3; AAI41070). SQ SEQUENCE 371 AA; 42015 MW; 52F1B373A928182B CRC64; MKMGHFEMVT TLLAAAVLMD IFQVKAEVLD MAENAFDDEY LKCKSRMESK YIPQMKREEW ANDALLRMVW DNAEIQWEAR KAQLFLPRNF KDTYGIALTA YVNEAQEQTS FYHTFSSAVK MAGLSRRRYI YNFPFKAFHF YLVRALQLLR RPCEKSYKTV VYSTSPDISF TFGEQNQARL GNFTLAYSAK PETADNQRVL TIQTCFGVAV GKFLNKEDDS VVLIPLSEVF QVSRKGTSND LVLQSINSTC SYYECAFLGG LKTENCIANA EYIDPRYLYN PDMDNQKLED SGRNNLDPDR MPEIKVLQTE ENPLLPDEKP DRSRGKANNP TPGLVPGPKS HPSASSGNTL LPSVMASTIL LVASAVNFIE L //