ID   NAR3_MOUSE              Reviewed;         371 AA.
AC   Q8R2G4; B2RUC2; O54738; Q8R2F9; Q8R2G0; Q8R2G1; Q8R2G2; Q8R2G3;
DT   13-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 2.
DT   10-FEB-2009, entry version 58.
DE   RecName: Full=Ecto-ADP-ribosyltransferase 3;
DE            EC=2.4.2.31;
DE   AltName: Full=NAD(P)(+)--arginine ADP-ribosyltransferase 3;
DE   AltName: Full=Mono(ADP-ribosyl)transferase 3;
DE   Flags: Precursor;
GN   Name=Art3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND
RP   6).
RX   MEDLINE=22065832; PubMed=12070318; DOI=10.1110/ps.0200602;
RA   Glowacki G., Braren R., Firner K., Nissen M., Kuehl M., Reche P.,
RA   Bazan J.F., Cetkovic-Cvrlje M., Leiter E., Haag F., Koch-Nolte F.;
RT   "The family of toxin-related ecto-ADP-ribosyltransferases in humans
RT   and the mouse.";
RL   Protein Sci. 11:1657-1670(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 8).
RC   TISSUE=Testis;
RA   Koch-Nolte F., Firner K., Haag F., Khl M., Thiele H.G.;
RT   "Molecular cloning of two ecto-mono(ADP-ribosyl)transferases operating
RT   in murine testis.";
RL   Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- CATALYTIC ACTIVITY: NAD(+) + protein-L-arginine = nicotinamide +
CC       N(omega)-(ADP-D-ribosyl)-protein-L-arginine.
CC   -!- CATALYTIC ACTIVITY: NADP(+) + protein-L-arginine = nicotinamide +
CC       N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor (By
CC       similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=8;
CC       Name=8;
CC         IsoId=Q8R2G4-5; Sequence=Displayed;
CC       Name=1;
CC         IsoId=Q8R2G4-1; Sequence=VSP_036194;
CC         Note=Non-canonical intron-exon junction (CA/AG). No experimental
CC         confirmation available;
CC       Name=2;
CC         IsoId=Q8R2G4-2; Sequence=VSP_036195;
CC       Name=3;
CC         IsoId=Q8R2G4-3; Sequence=VSP_036196;
CC       Name=4;
CC         IsoId=Q8R2G4-4; Sequence=VSP_036197;
CC       Name=6;
CC         IsoId=Q8R2G4-6; Sequence=VSP_036198;
CC         Note=Non-canonical intron-exon junction (CA/AG). No experimental
CC         confirmation available;
CC       Name=5;
CC         IsoId=Q8R2G4-7; Sequence=VSP_036193;
CC       Name=7;
CC         IsoId=Q8R2G4-8; Sequence=VSP_036199;
CC         Note=No experimental confirmation available;
CC   -!- PTM: Contains two disulfide bonds (By similarity).
CC   -!- SIMILARITY: Belongs to the Arg-specific ADP-ribosyltransferase
CC       family.
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DR   EMBL; AJ311768; CAC84539.1; -; Genomic_DNA.
DR   EMBL; AJ311769; CAC84526.1; -; mRNA.
DR   EMBL; AJ311770; CAC84540.1; -; mRNA.
DR   EMBL; AJ311771; CAC84541.1; -; mRNA.
DR   EMBL; AJ311772; CAC84542.1; -; mRNA.
DR   EMBL; AJ311773; CAC84543.1; -; mRNA.
DR   EMBL; Y08027; CAA69284.1; -; Genomic_DNA.
DR   EMBL; BC141069; AAI41070.1; -; mRNA.
DR   IPI; IPI00153579; -.
DR   IPI; IPI00229194; -.
DR   IPI; IPI00229195; -.
DR   IPI; IPI00229196; -.
DR   IPI; IPI00229197; -.
DR   IPI; IPI00229198; -.
DR   RefSeq; NP_859417.2; -.
DR   UniGene; Mm.263514; -.
DR   HSSP; P20974; 1GXY.
DR   PRIDE; Q8R2G4; -.
DR   Ensembl; ENSMUSG00000034842; Mus musculus.
DR   GeneID; 109979; -.
DR   KEGG; mmu:109979; -.
DR   MGI; MGI:1202729; Art3.
DR   HOGENOM; Q8R2G4; -.
DR   HOVERGEN; Q8R2G4; -.
DR   BRENDA; 2.4.2.31; 244.
DR   NextBio; 363113; -.
DR   Bgee; Q8R2G4; -.
DR   CleanEx; MM_ART3; -.
DR   GermOnline; ENSMUSG00000034842; Mus musculus.
DR   GO; GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003956; F:NAD(P)+-protein-arginine ADP-ribosyltransfe...; IEA:InterPro.
DR   GO; GO:0006471; P:protein amino acid ADP-ribosylation; IEA:InterPro.
DR   InterPro; IPR000768; ART.
DR   PANTHER; PTHR10339; ART; 1.
DR   Pfam; PF01129; ART; 1.
DR   PRINTS; PR00970; RIBTRNSFRASE.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell membrane; Glycoprotein;
KW   Glycosyltransferase; GPI-anchor; Lipoprotein; Membrane; NAD; NADP;
KW   Signal; Transferase.
FT   SIGNAL        1     26       Potential.
FT   CHAIN        27    345       Ecto-ADP-ribosyltransferase 3.
FT                                /FTId=PRO_0000019327.
FT   PROPEP      346    371       Removed in mature form (By similarity).
FT                                /FTId=PRO_0000019328.
FT   ACT_SITE    228    228       By similarity.
FT   LIPID       345    345       GPI-anchor amidated serine (By
FT                                similarity).
FT   VAR_SEQ     271    291       Missing (in isoform 5).
FT                                /FTId=VSP_036193.
FT   VAR_SEQ     282    371       DMDNQKLEDSGRNNLDPDRMPEIKVLQTEENPLLPDEKPDR
FT                                SRGKANNPTPGLVPGPKSHPSASSGNTLLPSVMASTILLVA
FT                                SAVNFIEL -> GEYTLLQTTQIWTIRSLKTLVPGIKPWAP
FT                                CKLVGTTLTLTECQKLKCYKQRKILSCRMKSLTEVEERPTI
FT                                LVRNTSFSLKNALKYKTVKLILFFIKSSRSGSRSEIPSLCI
FT                                LWQYAPSISHGIHHFTRCFCCKLHRAIA (in isoform
FT                                1).
FT                                /FTId=VSP_036194.
FT   VAR_SEQ     282    371       DMDNQKLEDSGRNNLDPDRMPEIKVLQTEENPLLPDEKPDR
FT                                SRGKANNPTPGLVPGPKSHPSASSGNTLLPSVMASTILLVA
FT                                SAVNFIEL -> GEYTLLQTTQIWTIRSLKTLVGTTLTLTE
FT                                CQKLKCYKQRKILSCRMKSLLQVWFQVRNPIPLHPLAIRSF
FT                                HQSWHPPFYSLLLL (in isoform 2).
FT                                /FTId=VSP_036195.
FT   VAR_SEQ     282    371       DMDNQKLEDSGRNNLDPDRMPEIKVLQTEENPLLPDEKPDR
FT                                SRGKANNPTPGLVPGPKSHPSASSGNTLLPSVMASTILLVA
FT                                SAVNFIEL -> GEYTLLQTTQIWTIRSLKTLVPGIKPWAP
FT                                CKLVGTTLTLTECQKLKCYKQRKILSCRMKSLLQVWFQVRN
FT                                PIPLHPLAIRSFHQSWHPPFYSLLLL (in isoform
FT                                3).
FT                                /FTId=VSP_036196.
FT   VAR_SEQ     282    371       DMDNQKLEDSGRNNLDPDRMPEIKVLQTEENPLLPDEKPDR
FT                                SRGKANNPTPGLVPGPKSHPSASSGNTLLPSVMASTILLVA
FT                                SAVNFIEL -> GEYTLLQTTQIWTIRSLKTLVGTTLTLTE
FT                                CQKLKCYKQRKILSCRMKSLTEVEERPTILLQVWFQVRNPI
FT                                PLHPLAIRSFHQSWHPPFYSLLLL (in isoform 4).
FT                                /FTId=VSP_036197.
FT   VAR_SEQ     282    371       DMDNQKLEDSGRNNLDPDRMPEIKVLQTEENPLLPDEKPDR
FT                                SRGKANNPTPGLVPGPKSHPSASSGNTLLPSVMASTILLVA
FT                                SAVNFIEL -> GEYTLLQTTQIWTIRSLKTLVGTTLTLTE
FT                                CQKLKCYKQRKILSCRMKSLTEVEERPTILVRNTSFSLKNA
FT                                LKYKTVKLILFFIKSSRSGSRSEIPSLCILWQYAPSISHGI
FT                                HHFTRCFCCKLHRAIA (in isoform 6).
FT                                /FTId=VSP_036198.
FT   VAR_SEQ     321    331       DRSRGKANNPT -> A (in isoform 7).
FT                                /FTId=VSP_036199.
FT   CONFLICT     11     15       TLLAA -> AAGS (in Ref. 2; CAA69284).
FT   CONFLICT    348    348       Missing (in Ref. 3; AAI41070).
SQ   SEQUENCE   371 AA;  42015 MW;  52F1B373A928182B CRC64;
     MKMGHFEMVT TLLAAAVLMD IFQVKAEVLD MAENAFDDEY LKCKSRMESK YIPQMKREEW
     ANDALLRMVW DNAEIQWEAR KAQLFLPRNF KDTYGIALTA YVNEAQEQTS FYHTFSSAVK
     MAGLSRRRYI YNFPFKAFHF YLVRALQLLR RPCEKSYKTV VYSTSPDISF TFGEQNQARL
     GNFTLAYSAK PETADNQRVL TIQTCFGVAV GKFLNKEDDS VVLIPLSEVF QVSRKGTSND
     LVLQSINSTC SYYECAFLGG LKTENCIANA EYIDPRYLYN PDMDNQKLED SGRNNLDPDR
     MPEIKVLQTE ENPLLPDEKP DRSRGKANNP TPGLVPGPKS HPSASSGNTL LPSVMASTIL
     LVASAVNFIE L
//