ID   NAR3_MOUSE              Reviewed;         371 AA.
AC   Q8R2G4; B2RUC2; O54738; Q8R2F9; Q8R2G0; Q8R2G1; Q8R2G2; Q8R2G3;
DT   13-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 2.
DT   14-MAY-2014, entry version 102.
DE   RecName: Full=Ecto-ADP-ribosyltransferase 3;
DE            EC=2.4.2.31;
DE   AltName: Full=ADP-ribosyltransferase C2 and C3 toxin-like 3;
DE            Short=ARTC3;
DE   AltName: Full=Mono(ADP-ribosyl)transferase 3;
DE   AltName: Full=NAD(P)(+)--arginine ADP-ribosyltransferase 3;
DE   Flags: Precursor;
GN   Name=Art3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 5).
RX   PubMed=12070318; DOI=10.1110/ps.0200602;
RA   Glowacki G., Braren R., Firner K., Nissen M., Kuehl M., Reche P.,
RA   Bazan J.F., Cetkovic-Cvrlje M., Leiter E., Haag F., Koch-Nolte F.;
RT   "The family of toxin-related ecto-ADP-ribosyltransferases in humans
RT   and the mouse.";
RL   Protein Sci. 11:1657-1670(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 8).
RC   TISSUE=Testis;
RA   Koch-Nolte F., Firner K., Haag F., Khl M., Thiele H.G.;
RT   "Molecular cloning of two ecto-mono(ADP-ribosyl)transferases operating
RT   in murine testis.";
RL   Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- CATALYTIC ACTIVITY: NAD(+) + protein-L-arginine = nicotinamide +
CC       N(omega)-(ADP-D-ribosyl)-protein-L-arginine.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor (By
CC       similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=8;
CC         IsoId=Q8R2G4-5; Sequence=Displayed;
CC       Name=5;
CC         IsoId=Q8R2G4-7; Sequence=VSP_036193;
CC       Name=7;
CC         IsoId=Q8R2G4-8; Sequence=VSP_036199;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Belongs to the Arg-specific ADP-ribosyltransferase
CC       family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAC84526.1; Type=Miscellaneous discrepancy; Note=3'extension leads to out-of-frame translation;
CC       Sequence=CAC84539.1; Type=Erroneous gene model prediction;
CC       Sequence=CAC84540.1; Type=Miscellaneous discrepancy; Note=3'extension leads to out-of-frame translation;
CC       Sequence=CAC84541.1; Type=Miscellaneous discrepancy; Note=3'extension leads to out-of-frame translation;
CC       Sequence=CAC84543.1; Type=Miscellaneous discrepancy; Note=3'extension leads to out-of-frame translation;
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DR   EMBL; AJ311768; CAC84539.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AJ311769; CAC84526.1; ALT_SEQ; mRNA.
DR   EMBL; AJ311770; CAC84540.1; ALT_SEQ; mRNA.
DR   EMBL; AJ311771; CAC84541.1; ALT_SEQ; mRNA.
DR   EMBL; AJ311772; CAC84542.1; -; mRNA.
DR   EMBL; AJ311773; CAC84543.1; ALT_SEQ; mRNA.
DR   EMBL; Y08027; CAA69284.1; -; Genomic_DNA.
DR   EMBL; BC141069; AAI41070.1; -; mRNA.
DR   RefSeq; NP_859417.2; NM_181728.2. [Q8R2G4-8]
DR   RefSeq; XP_006534780.1; XM_006534717.1. [Q8R2G4-5]
DR   RefSeq; XP_006534781.1; XM_006534718.1. [Q8R2G4-8]
DR   UniGene; Mm.263514; -.
DR   ProteinModelPortal; Q8R2G4; -.
DR   SMR; Q8R2G4; 28-257.
DR   MaxQB; Q8R2G4; -.
DR   PaxDb; Q8R2G4; -.
DR   PRIDE; Q8R2G4; -.
DR   DNASU; 109979; -.
DR   Ensembl; ENSMUST00000113083; ENSMUSP00000108706; ENSMUSG00000034842. [Q8R2G4-8]
DR   Ensembl; ENSMUST00000118106; ENSMUSP00000114083; ENSMUSG00000034842.
DR   Ensembl; ENSMUST00000119587; ENSMUSP00000112648; ENSMUSG00000034842. [Q8R2G4-7]
DR   Ensembl; ENSMUST00000120193; ENSMUSP00000113074; ENSMUSG00000034842.
DR   Ensembl; ENSMUST00000120416; ENSMUSP00000113493; ENSMUSG00000034842.
DR   GeneID; 109979; -.
DR   KEGG; mmu:109979; -.
DR   UCSC; uc008ycw.1; mouse. [Q8R2G4-5]
DR   UCSC; uc008ycy.2; mouse. [Q8R2G4-8]
DR   UCSC; uc008ydg.2; mouse. [Q8R2G4-7]
DR   CTD; 419; -.
DR   MGI; MGI:1202729; Art3.
DR   eggNOG; NOG27376; -.
DR   GeneTree; ENSGT00530000062975; -.
DR   HOVERGEN; HBG006445; -.
DR   InParanoid; Q8R2G4; -.
DR   KO; K00775; -.
DR   PhylomeDB; Q8R2G4; -.
DR   TreeFam; TF335356; -.
DR   NextBio; 363113; -.
DR   PRO; PR:Q8R2G4; -.
DR   ArrayExpress; Q8R2G4; -.
DR   Bgee; Q8R2G4; -.
DR   CleanEx; MM_ART3; -.
DR   Genevestigator; Q8R2G4; -.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003956; F:NAD(P)+-protein-arginine ADP-ribosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006471; P:protein ADP-ribosylation; IEA:InterPro.
DR   InterPro; IPR000768; ART.
DR   PANTHER; PTHR10339; PTHR10339; 1.
DR   Pfam; PF01129; ART; 1.
DR   PRINTS; PR00970; RIBTRNSFRASE.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell membrane; Complete proteome;
KW   Disulfide bond; Glycoprotein; Glycosyltransferase; GPI-anchor;
KW   Lipoprotein; Membrane; NAD; NADP; Reference proteome; Signal;
KW   Transferase.
FT   SIGNAL        1     26       Potential.
FT   CHAIN        27    345       Ecto-ADP-ribosyltransferase 3.
FT                                /FTId=PRO_0000019327.
FT   PROPEP      346    371       Removed in mature form (By similarity).
FT                                /FTId=PRO_0000019328.
FT   ACT_SITE    228    228       By similarity.
FT   BINDING     101    101       NAD (By similarity).
FT   BINDING     182    182       NAD (By similarity).
FT   LIPID       345    345       GPI-anchor amidated serine (By
FT                                similarity).
FT   DISULFID     43    255       By similarity.
FT   VAR_SEQ     271    291       Missing (in isoform 5).
FT                                /FTId=VSP_036193.
FT   VAR_SEQ     321    331       DRSRGKANNPT -> A (in isoform 7).
FT                                /FTId=VSP_036199.
FT   CONFLICT     11     15       TLLAA -> AAGS (in Ref. 2; CAA69284).
FT   CONFLICT    348    348       Missing (in Ref. 3; AAI41070).
SQ   SEQUENCE   371 AA;  42015 MW;  52F1B373A928182B CRC64;
     MKMGHFEMVT TLLAAAVLMD IFQVKAEVLD MAENAFDDEY LKCKSRMESK YIPQMKREEW
     ANDALLRMVW DNAEIQWEAR KAQLFLPRNF KDTYGIALTA YVNEAQEQTS FYHTFSSAVK
     MAGLSRRRYI YNFPFKAFHF YLVRALQLLR RPCEKSYKTV VYSTSPDISF TFGEQNQARL
     GNFTLAYSAK PETADNQRVL TIQTCFGVAV GKFLNKEDDS VVLIPLSEVF QVSRKGTSND
     LVLQSINSTC SYYECAFLGG LKTENCIANA EYIDPRYLYN PDMDNQKLED SGRNNLDPDR
     MPEIKVLQTE ENPLLPDEKP DRSRGKANNP TPGLVPGPKS HPSASSGNTL LPSVMASTIL
     LVASAVNFIE L
//