ID TM134_MOUSE Reviewed; 195 AA. AC Q8R0J4; Q3TLG9; Q8C1M3; Q9CR66; DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2002, sequence version 1. DT 15-DEC-2009, entry version 43. DE RecName: Full=Transmembrane protein 134; GN Name=Tmem134; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). RC STRAIN=C57BL/6J; RC TISSUE=Embryonic stem cell, Kidney, Mammary gland, and Tongue; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC STRAIN=FVB/N; TISSUE=Salivary gland; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein CC (Potential). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q8R0J4-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8R0J4-2; Sequence=VSP_023456; CC Name=3; CC IsoId=Q8R0J4-3; Sequence=VSP_023455; CC Note=No experimental confirmation available; CC -!- SIMILARITY: Belongs to the UPF0414 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK002220; BAB21944.1; -; mRNA. DR EMBL; AK009745; BAB26475.1; -; mRNA. DR EMBL; AK010323; BAC25290.1; -; mRNA. DR EMBL; AK166519; BAE38823.1; -; mRNA. DR EMBL; BC026765; AAH26765.1; -; mRNA. DR IPI; IPI00380372; -. DR IPI; IPI00816915; -. DR IPI; IPI00830779; -. DR RefSeq; NP_001072117.1; -. DR RefSeq; NP_080165.1; -. DR UniGene; Mm.276255; -. DR Ensembl; ENSMUST00000064575; ENSMUSP00000067397; ENSMUSG00000024845; Mus musculus. DR Ensembl; ENSMUST00000071372; ENSMUSP00000071327; ENSMUSG00000024845; Mus musculus. DR GeneID; 66990; -. DR KEGG; mmu:66990; -. DR UCSC; uc008fyr.1; mouse. DR CTD; 66990; -. DR MGI; MGI:1914240; Tmem134. DR HOGENOM; HBG713716; -. DR HOVERGEN; Q8R0J4; -. DR InParanoid; Q8R0J4; -. DR NextBio; 323232; -. DR ArrayExpress; Q8R0J4; -. DR Bgee; Q8R0J4; -. DR CleanEx; MM_TMEM134; -. DR Genevestigator; Q8R0J4; -. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell. DR InterPro; IPR008590; UPF0414. DR Pfam; PF05915; DUF872; 1. PE 2: Evidence at transcript level; KW Alternative splicing; Membrane; Transmembrane. FT CHAIN 1 195 Transmembrane protein 134. FT /FTId=PRO_0000279486. FT TOPO_DOM 1 122 Cytoplasmic (Potential). FT TRANSMEM 123 143 Potential. FT TOPO_DOM 144 154 Extracellular (Potential). FT TRANSMEM 155 175 Potential. FT TOPO_DOM 176 195 Cytoplasmic (Potential). FT VAR_SEQ 80 88 Missing (in isoform 3). FT /FTId=VSP_023455. FT VAR_SEQ 136 150 Missing (in isoform 2). FT /FTId=VSP_023456. FT CONFLICT 66 66 G -> R (in Ref. 1; BAE38823). SQ SEQUENCE 195 AA; 21637 MW; D34CCCC924937662 CRC64; MSAARPQFSI DDAFELTLED AGPEPESSGV ARFGPLHFER RARFEVADED KQSRLRYQNL ENDEDGAQAS PEPDGGVSTR DSGHMSVRSS QWSFSTISSS TQRSYNACCS WTQHPLIQKN RRVVLASFLL LLLGLVLILV GVGLEVAPSP GVSSAIFFVP GILLLVPGVY HVIFIYCAVK GRRGFQFFYL PYFEK //