ID TM134_MOUSE Reviewed; 195 AA. AC Q8R0J4; Q3TLG9; Q8C1M3; Q9CR66; DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2002, sequence version 1. DT 29-MAY-2024, entry version 108. DE RecName: Full=Transmembrane protein 134; GN Name=Tmem134; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). RC STRAIN=C57BL/6J; RC TISSUE=Embryonic stem cell, Kidney, Mammary gland, and Tongue; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC STRAIN=FVB/N; TISSUE=Salivary gland; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-93, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Kidney, Liver, and Spleen; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. Cytoplasm, perinuclear region CC {ECO:0000250|UniProtKB:Q9H6X4}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q8R0J4-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8R0J4-2; Sequence=VSP_023456; CC Name=3; CC IsoId=Q8R0J4-3; Sequence=VSP_023455; CC -!- SIMILARITY: Belongs to the TMEM134/TMEM230 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK002220; BAB21944.1; -; mRNA. DR EMBL; AK009745; BAB26475.1; -; mRNA. DR EMBL; AK010323; BAC25290.1; -; mRNA. DR EMBL; AK166519; BAE38823.1; -; mRNA. DR EMBL; BC026765; AAH26765.1; -; mRNA. DR RefSeq; NP_001072117.1; NM_001078649.1. [Q8R0J4-1] DR RefSeq; NP_080165.1; NM_025889.2. [Q8R0J4-2] DR AlphaFoldDB; Q8R0J4; -. DR STRING; 10090.ENSMUSP00000158987; -. DR iPTMnet; Q8R0J4; -. DR PhosphoSitePlus; Q8R0J4; -. DR SwissPalm; Q8R0J4; -. DR jPOST; Q8R0J4; -. DR MaxQB; Q8R0J4; -. DR PeptideAtlas; Q8R0J4; -. DR ProteomicsDB; 260675; -. [Q8R0J4-1] DR ProteomicsDB; 260676; -. [Q8R0J4-2] DR ProteomicsDB; 260677; -. [Q8R0J4-3] DR Pumba; Q8R0J4; -. DR Antibodypedia; 30426; 82 antibodies from 14 providers. DR DNASU; 66990; -. DR Ensembl; ENSMUST00000139987.10; ENSMUSP00000159417.2; ENSMUSG00000024845.20. [Q8R0J4-3] DR Ensembl; ENSMUST00000140267.10; ENSMUSP00000159415.2; ENSMUSG00000024845.20. [Q8R0J4-1] DR Ensembl; ENSMUST00000150627.11; ENSMUSP00000158987.4; ENSMUSG00000024845.20. [Q8R0J4-2] DR Ensembl; ENSMUST00000169055.10; ENSMUSP00000159412.2; ENSMUSG00000024845.20. [Q8R0J4-2] DR GeneID; 66990; -. DR KEGG; mmu:66990; -. DR UCSC; uc008fyr.1; mouse. [Q8R0J4-1] DR UCSC; uc008fys.1; mouse. [Q8R0J4-2] DR AGR; MGI:1914240; -. DR CTD; 80194; -. DR MGI; MGI:1914240; Tmem134. DR VEuPathDB; HostDB:ENSMUSG00000024845; -. DR GeneTree; ENSGT00390000011766; -. DR InParanoid; Q8R0J4; -. DR OrthoDB; 3172222at2759; -. DR PhylomeDB; Q8R0J4; -. DR BioGRID-ORCS; 66990; 0 hits in 17 CRISPR screens. DR ChiTaRS; Tmem134; mouse. DR PRO; PR:Q8R0J4; -. DR Proteomes; UP000000589; Chromosome 19. DR RNAct; Q8R0J4; Protein. DR Bgee; ENSMUSG00000024845; Expressed in lip and 175 other cell types or tissues. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. DR InterPro; IPR039714; TMEM134. DR InterPro; IPR008590; TMEM_230/134. DR PANTHER; PTHR13558:SF1; TRANSMEMBRANE PROTEIN 134; 1. DR PANTHER; PTHR13558; UNCHARACTERIZED; 1. DR Pfam; PF05915; TMEM_230_134; 1. PE 1: Evidence at protein level; KW Alternative splicing; Cytoplasm; Membrane; Phosphoprotein; KW Reference proteome; Transmembrane; Transmembrane helix. FT CHAIN 1..195 FT /note="Transmembrane protein 134" FT /id="PRO_0000279486" FT TOPO_DOM 1..122 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 123..143 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 144..154 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 155..175 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 176..195 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT REGION 14..33 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 48..84 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 93 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT VAR_SEQ 80..88 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:16141072" FT /id="VSP_023455" FT VAR_SEQ 136..150 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:16141072" FT /id="VSP_023456" FT CONFLICT 66 FT /note="G -> R (in Ref. 1; BAE38823)" FT /evidence="ECO:0000305" SQ SEQUENCE 195 AA; 21637 MW; D34CCCC924937662 CRC64; MSAARPQFSI DDAFELTLED AGPEPESSGV ARFGPLHFER RARFEVADED KQSRLRYQNL ENDEDGAQAS PEPDGGVSTR DSGHMSVRSS QWSFSTISSS TQRSYNACCS WTQHPLIQKN RRVVLASFLL LLLGLVLILV GVGLEVAPSP GVSSAIFFVP GILLLVPGVY HVIFIYCAVK GRRGFQFFYL PYFEK //