ID Q8PHC8_XANAC Unreviewed; 568 AA. AC Q8PHC8; DT 01-OCT-2002, integrated into UniProtKB/TrEMBL. DT 01-OCT-2002, sequence version 1. DT 14-OCT-2008, entry version 34. DE SubName: Full=NADPH-sulfite reductase iron-sulfur protein; GN Name=cysI; OS Xanthomonas axonopodis pv. citri (Citrus canker). OC Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales; OC Xanthomonadaceae; Xanthomonas. OX NCBI_TaxID=92829; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=306; RX MEDLINE=22022145; PubMed=12024217; DOI=10.1038/417459a; RA da Silva A.C.R., Ferro J.A., Reinach F.C., Farah C.S., Furlan L.R., RA Quaggio R.B., Monteiro-Vitorello C.B., Van Sluys M.A., RA Almeida N.F. Jr., Alves L.M.C., do Amaral A.M., Bertolini M.C., RA Camargo L.E.A., Camarotte G., Cannavan F., Cardozo J., Chambergo F., RA Ciapina L.P., Cicarelli R.M.B., Coutinho L.L., Cursino-Santos J.R., RA El-Dorry H., Faria J.B., Ferreira A.J.S., Ferreira R.C.C., RA Ferro M.I.T., Formighieri E.F., Franco M.C., Greggio C.C., Gruber A., RA Katsuyama A.M., Kishi L.T., Leite R.P., Lemos E.G.M., Lemos M.V.F., RA Locali E.C., Machado M.A., Madeira A.M.B.N., Martinez-Rossi N.M., RA Martins E.C., Meidanis J., Menck C.F.M., Miyaki C.Y., Moon D.H., RA Moreira L.M., Novo M.T.M., Okura V.K., Oliveira M.C., Oliveira V.R., RA Pereira H.A., Rossi A., Sena J.A.D., Silva C., de Souza R.F., RA Spinola L.A.F., Takita M.A., Tamura R.E., Teixeira E.C., Tezza R.I.D., RA Trindade dos Santos M., Truffi D., Tsai S.M., White F.F., RA Setubal J.C., Kitajima J.P.; RT "Comparison of the genomes of two Xanthomonas pathogens with differing RT host specificities."; RL Nature 417:459-463(2002). CC -!- FUNCTION: This enzyme catalyzes the 6-electron reduction of CC sulfite to sulfide. This is one of several activities required for CC the biosynthesis of L-cysteine from sulfate. CC -!- CATALYTIC ACTIVITY: H(2)S + 3 NADP(+) + 3 H(2)O = sulfite + 3 CC NADPH. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE011979; AAM38174.1; -; Genomic_DNA. DR RefSeq; NP_643638.1; -. DR HSSP; P17846; 7GEP. DR GeneID; 1157402; -. DR GenomeReviews; AE008923_GR; cysI. DR NMPDR; fig|190486.1.peg.3282; -. DR HOGENOM; Q8PHC8; -. DR BioCyc; XAXO190486:XAC3331-MON; -. DR GO; GO:0009337; C:sulfite reductase complex (NADPH); IEA:InterPro. DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro. DR GO; GO:0009055; F:electron carrier activity; IEA:InterPro. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW. DR GO; GO:0050661; F:NADP binding; IEA:InterPro. DR GO; GO:0004783; F:sulfite reductase (NADPH) activity; IEA:InterPro. DR GO; GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW. DR GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW. DR InterPro; IPR011786; CysI. DR InterPro; IPR006066; Nir_Si_BS. DR InterPro; IPR006067; Nir_Sir_4Fe4S. DR InterPro; IPR005117; NiRdtase/SiRdtase_haem-b_fer. DR Pfam; PF01077; NIR_SIR; 1. DR Pfam; PF03460; NIR_SIR_ferr; 2. DR PRINTS; PR00397; SIROHAEM. DR TIGRFAMs; TIGR02041; CysI; 1. DR PROSITE; PS00365; NIR_SIR; 1. PE 4: Predicted; KW 4Fe-4S; Amino-acid biosynthesis; Complete proteome; KW Cysteine biosynthesis; Heme; Iron; Iron-sulfur; Metal-binding; NADP; KW Oxidoreductase. SQ SEQUENCE 568 AA; 62418 MW; 4E86EDBFF11AE961 CRC64; MSHSVEDIKS ESRRLRGSLE QSLADAVTGA LREDDQTLIK YHGSYQQDDR DIRDERRRQK LEPAYQFMIR TRTPGGVITP TQWLALDGIA TRYANHSLRI TTRQAFQFHG VIKRELKATM QAINATLIDT LAACGDVNRN VQVAANPLLS QAHATLYADA ARVSEHLLPN TRAYYEIWLD EERVSGSGSE DEPIYGERYL PRKFKIGFAA PPLNDVDVFA NDLGFIAILR DGQLLGYNVS IGGGMGASHG DAETWPRVAN VIGFVTREQL LDIATAVVTT QRDFGNRAVR KRARFKYTID DHGLDTIVAE IARRAGFALQ PAQPFAFDHN GDRYGWVEGE DGLWHLTLSL PAGRIADTDT AAHLSGLRAI AQLNVGEFRM TPNQNLVIAG VLASERARVD ALVAHYGLDA GNQSATALAR GAMACVALPT CGLAMAEAER YLPDFGAALQ PLLQQHGLAE TPIVLRLSGC PNGCSRPYLA EIALVGKAPG RYNLMLGGDR RGQRLNTLYR ENITEPEILA ALEPLLARYA AERDHANDEG FGDFLHRAGV IALPPYPTHR RLDLELLA //