ID PUR9_XANCP Reviewed; 527 AA. AC Q8PD47; DT 20-JUN-2003, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 1. DT 02-OCT-2007, entry version 30. DE Bifunctional purine biosynthesis protein purH [Includes: DE Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) DE (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) DE (IMP synthetase) (ATIC)]. GN Name=purH; OrderedLocusNames=XCC0498; OS Xanthomonas campestris pv. campestris. OC Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales; OC Xanthomonadaceae; Xanthomonas. OX NCBI_TaxID=340; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 33913 / NCPPB 528 / LMG 568; RX MEDLINE=22022145; PubMed=12024217; DOI=10.1038/417459a; RA da Silva A.C.R., Ferro J.A., Reinach F.C., Farah C.S., Furlan L.R., RA Quaggio R.B., Monteiro-Vitorello C.B., Van Sluys M.A., RA Almeida N.F. Jr., Alves L.M.C., do Amaral A.M., Bertolini M.C., RA Camargo L.E.A., Camarotte G., Cannavan F., Cardozo J., Chambergo F., RA Ciapina L.P., Cicarelli R.M.B., Coutinho L.L., Cursino-Santos J.R., RA El-Dorry H., Faria J.B., Ferreira A.J.S., Ferreira R.C.C., RA Ferro M.I.T., Formighieri E.F., Franco M.C., Greggio C.C., Gruber A., RA Katsuyama A.M., Kishi L.T., Leite R.P., Lemos E.G.M., Lemos M.V.F., RA Locali E.C., Machado M.A., Madeira A.M.B.N., Martinez-Rossi N.M., RA Martins E.C., Meidanis J., Menck C.F.M., Miyaki C.Y., Moon D.H., RA Moreira L.M., Novo M.T.M., Okura V.K., Oliveira M.C., Oliveira V.R., RA Pereira H.A., Rossi A., Sena J.A.D., Silva C., de Souza R.F., RA Spinola L.A.F., Takita M.A., Tamura R.E., Teixeira E.C., Tezza R.I.D., RA Trindade dos Santos M., Truffi D., Tsai S.M., White F.F., RA Setubal J.C., Kitajima J.P.; RT "Comparison of the genomes of two Xanthomonas pathogens with differing RT host specificities."; RL Nature 417:459-463(2002). CC -!- CATALYTIC ACTIVITY: 10-formyltetrahydrofolate + 5-amino-1-(5- CC phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5- CC formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. CC -!- CATALYTIC ACTIVITY: IMP + H(2)O = 5-formamido-1-(5-phospho-D- CC ribosyl)imidazole-4-carboxamide. CC -!- PATHWAY: Nucleotide biosynthesis; IMP biosynthesis; 5-formamido-1- CC (5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5- CC phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): CC step 1/1. CC -!- PATHWAY: Nucleotide biosynthesis; IMP biosynthesis; IMP from 5- CC formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step CC 1/1. CC -!- PATHWAY: Context: Purine biosynthesis. CC -!- DOMAIN: The IMP cyclohydrolase activity resides in the N-terminal CC region (By similarity). CC -!- SIMILARITY: Belongs to the purH family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE012147; AAM39814.1; -; Genomic_DNA. DR RefSeq; NP_635890.1; -. DR HSSP; P31335; 1G8M. DR GeneID; 1001009; -. DR GenomeReviews; AE008922_GR; XCC0498. DR KEGG; xcc:XCC0498; -. DR BioCyc; XCAM190485:XCC0498-MONOMER; -. DR GO; GO:0003937; F:IMP cyclohydrolase activity; IEA:HAMAP. DR GO; GO:0004643; F:phosphoribosylaminoimidazolecarboxamide for...; IEA:HAMAP. DR GO; GO:0006164; P:purine nucleotide biosynthetic process; IEA:HAMAP. DR HAMAP; MF_00139; -; 1. DR InterPro; IPR002695; AICARFT_IMPCHas. DR InterPro; IPR013982; AICARFT_IMPCHas_formly. DR InterPro; IPR011607; MGS. DR PANTHER; PTHR11692; AICARFT_IMPCHas; 1. DR Pfam; PF01808; AICARFT_IMPCHas; 1. DR Pfam; PF02142; MGS; 1. DR ProDom; PD004666; AICARFT_IMPCHas; 1. DR SMART; SM00798; AICARFT_IMPCHas; 1. DR TIGRFAMs; TIGR00355; purH; 1. PE 3: Inferred from homology; KW Complete proteome; Hydrolase; Multifunctional enzyme; KW Purine biosynthesis; Transferase. FT CHAIN 1 527 Bifunctional purine biosynthesis protein FT purH. FT /FTId=PRO_0000192150. SQ SEQUENCE 527 AA; 55656 MW; AB8D097E73B3E51E CRC64; MASDFLPVRR ALLSVSDKTG LIDLARALVA RNVELLSTGG TAKAIRDAGL PVKDVAELTG FPEMMDGRVK TLHPLVHGGL LGRAGVDEAV MAEHGIAPID LLVLNLYPFE SVTAKADCTL ADAVENIDIG GPAMLRSAAK NFARVAVATD PAQYADLLAE LEANNGQLSA AQRFALSVAA FNRVAQYDAA ISNYLSAVAD SAESVPTRSP FPAQINSNFI KVMDLRYGEN PHQSGAFYRD LYPVPGTLAT FQQLQGKELS YNNLADADAA WECVRQFDAP ACVIVKHANP CGVAVGVACG DAYELAYATD PTSAFGGILA FNRTLDAATA KAILDRQFVE VLIAPDYEPG ALDYATKKAN VRVLKIPHGA GLNNYDTKRI GSGLLMQSAD NRGMSLGELS VVTKRAPSDA ELADLLFAWR VAKYVKSNAI VYAKDSRTIG VGAGQMSRVV SAKIAALKAE EAKLTVAGSV MASDAFFPFR DGIDAAAAAG IQAVIQPGGS MRDGEVIAAA DEHGLAMVFT GVRHFRH //