ID Q8NI47_HUMAN Unreviewed; 48 AA. AC Q8NI47; DT 01-OCT-2002, integrated into UniProtKB/TrEMBL. DT 01-OCT-2002, sequence version 1. DT 14-DEC-2022, entry version 94. DE SubName: Full=Synovial phospholipase-A2 {ECO:0000313|EMBL:AAM21271.1}; DE Flags: Fragment; GN Name=PLA2G2A {ECO:0000313|EMBL:AAM21271.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAM21271.1}; RN [1] {ECO:0000313|EMBL:AAM21271.1} RP NUCLEOTIDE SEQUENCE. RA Kostka H.; RT "New missense mutations in the PLA2G2A gene."; RL Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases. CC -!- COFACTOR: CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108; CC Evidence={ECO:0000256|PIRSR:PIRSR601211-2}; CC Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR601211-2}; CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}. CC -!- SIMILARITY: Belongs to the phospholipase A2 family. CC {ECO:0000256|ARBA:ARBA00007056}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF368841; AAM21271.1; -; Genomic_DNA. DR AlphaFoldDB; Q8NI47; -. DR PeptideAtlas; Q8NI47; -. DR ChiTaRS; PLA2G2A; human. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0004623; F:phospholipase A2 activity; IEA:InterPro. DR GO; GO:0050482; P:arachidonic acid secretion; IEA:InterPro. DR GO; GO:0016042; P:lipid catabolic process; IEA:InterPro. DR GO; GO:0006644; P:phospholipid metabolic process; IEA:InterPro. DR Gene3D; 1.20.90.10; -; 1. DR InterPro; IPR001211; PLipase_A2. DR InterPro; IPR016090; PLipase_A2_dom. DR InterPro; IPR036444; PLipase_A2_dom_sf. DR PANTHER; PTHR11716; PHOSPHOLIPASE A2 FAMILY MEMBER; 1. DR Pfam; PF00068; Phospholip_A2_1; 1. DR PRINTS; PR00389; PHPHLIPASEA2. DR SUPFAM; SSF48619; Phospholipase A2, PLA2; 1. PE 3: Inferred from homology; KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR601211-2}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, KW ECO:0000256|PIRSR:PIRSR601211-2}; Secreted {ECO:0000256|ARBA:ARBA00022525}. FT DOMAIN 8..48 FT /note="PA2c" FT /evidence="ECO:0000259|Pfam:PF00068" FT BINDING 35 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /evidence="ECO:0000256|PIRSR:PIRSR601211-2" FT BINDING 37 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /evidence="ECO:0000256|PIRSR:PIRSR601211-2" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AAM21271.1" FT NON_TER 48 FT /evidence="ECO:0000313|EMBL:AAM21271.1" SQ SEQUENCE 48 AA; 5168 MW; 6297E410A0FAAD92 CRC64; LLQARGNLVN FHRMIKLTTG KEAALSYGFY GCHCGVGGRG SPKDATDR //