ID   OR1L3_HUMAN             Reviewed;         324 AA.
AC   Q8NH93; B2RNF4; Q6IFN1;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   08-NOV-2023, entry version 155.
DE   RecName: Full=Olfactory receptor 1L3;
DE   AltName: Full=Olfactory receptor 9-D;
DE            Short=OR9-D;
DE   AltName: Full=Olfactory receptor OR9-28;
GN   Name=OR1L3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [6]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- INTERACTION:
CC       Q8NH93; P32243-2: OTX2; NbExp=3; IntAct=EBI-13080292, EBI-9087860;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1L3";
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DR   EMBL; AB065492; BAC05744.1; -; Genomic_DNA.
DR   EMBL; AL162254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471090; EAW87541.1; -; Genomic_DNA.
DR   EMBL; BC136857; AAI36858.1; -; mRNA.
DR   EMBL; BC136859; AAI36860.1; -; mRNA.
DR   EMBL; BK004231; DAA04629.1; -; Genomic_DNA.
DR   CCDS; CCDS35128.1; -.
DR   RefSeq; NP_001005234.1; NM_001005234.1.
DR   AlphaFoldDB; Q8NH93; -.
DR   SMR; Q8NH93; -.
DR   BioGRID; 117803; 2.
DR   IntAct; Q8NH93; 1.
DR   STRING; 9606.ENSP00000302863; -.
DR   GlyCosmos; Q8NH93; 1 site, No reported glycans.
DR   GlyGen; Q8NH93; 1 site.
DR   BioMuta; OR1L3; -.
DR   DMDM; 38372830; -.
DR   MassIVE; Q8NH93; -.
DR   MaxQB; Q8NH93; -.
DR   PaxDb; 9606-ENSP00000302863; -.
DR   PeptideAtlas; Q8NH93; -.
DR   ProteomicsDB; 73689; -.
DR   Antibodypedia; 72098; 29 antibodies from 18 providers.
DR   DNASU; 26735; -.
DR   Ensembl; ENST00000304820.5; ENSP00000302863.2; ENSG00000171481.5.
DR   GeneID; 26735; -.
DR   KEGG; hsa:26735; -.
DR   MANE-Select; ENST00000304820.5; ENSP00000302863.2; NM_001005234.1; NP_001005234.1.
DR   UCSC; uc011lzb.2; human.
DR   AGR; HGNC:8215; -.
DR   CTD; 26735; -.
DR   GeneCards; OR1L3; -.
DR   HGNC; HGNC:8215; OR1L3.
DR   HPA; ENSG00000171481; Not detected.
DR   neXtProt; NX_Q8NH93; -.
DR   PharmGKB; PA32085; -.
DR   VEuPathDB; HostDB:ENSG00000171481; -.
DR   eggNOG; ENOG502T9M9; Eukaryota.
DR   GeneTree; ENSGT00940000163223; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; Q8NH93; -.
DR   OMA; ITFSYLH; -.
DR   OrthoDB; 5401587at2759; -.
DR   PhylomeDB; Q8NH93; -.
DR   TreeFam; TF341149; -.
DR   PathwayCommons; Q8NH93; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 26735; 5 hits in 735 CRISPR screens.
DR   GeneWiki; OR1L3; -.
DR   GenomeRNAi; 26735; -.
DR   Pharos; Q8NH93; Tdark.
DR   PRO; PR:Q8NH93; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q8NH93; Protein.
DR   Bgee; ENSG00000171481; Expressed in anterior cingulate cortex.
DR   ExpressionAtlas; Q8NH93; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   CDD; cd15235; 7tmA_OR1A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48001; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48001:SF49; OLFACTORY RECEPTOR 1L3; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..324
FT                   /note="Olfactory receptor 1L3"
FT                   /id="PRO_0000150443"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..49
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..79
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..236
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..259
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..291
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..324
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         54
FT                   /note="R -> G (in dbSNP:rs12379744)"
FT                   /id="VAR_059979"
FT   VARIANT         106
FT                   /note="V -> A (in dbSNP:rs16912096)"
FT                   /id="VAR_034169"
FT   VARIANT         121
FT                   /note="N -> D (in dbSNP:rs16912099)"
FT                   /id="VAR_034170"
SQ   SEQUENCE   324 AA;  36633 MW;  088889EBE28353F8 CRC64;
     MGMSNLTRLS EFILLGLSSR SEDQRPLFAL FLIIYLVTLM GNLLIILAIH SDPRLQNPMY
     FFLSILSFAD ICYTTVIVPK MLVNFLSEKK TISYAECLAQ MYFFLVFGNI DSYLLAAMAI
     NRCVAICNPF HYVTVMNRRC CVLLLAFPIT FSYFHSLLHV LLVNRLTFCT SNVIHHFFCD
     VNPVLKLSCS STFVNEIVAM TEGLASVMAP FVCIIISYLR ILIAVLKIPS AAGKHKAFST
     CSSHLTVVIL FYGSISYVYL QPLSSYTVKD RIATINYTVL TSVLNPFIYS LRNKDMKRGL
     QKLINKIKSQ MSRFSTKTNK ICGP
//